Regulation of actin cytoskeleton (Mus musculus)

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GFLamellipodiaActomyosinassembly contraction+pPI3KGPCRGrowth Factor (GF)Filipodiastress fiberChemotactic factorFocal adhesionassemblyRASFocal adhesionpathwayGPCRActin polymerizationstress fiber-p?Chemotatic factorActin polymerizationFocal adhesion pathwayActin polymerizationGene ExpressionRTKRTKPI3KMAPK Signaling pathwayRASFocal complexassemblyStabilization of actinAdherens junctionpathwayGrlf1Fgf15Mapk4Fgf17Pip4k2aFgfr2LPSRac4RhoaPak2Baiap2Arpc5Tmsb4xFgf11Fgf2EgfrGna12Rac2Limk1Arhgef4Fgf12Map2k1Fgfr1Ssh1Diap1Pak1MosDock1Fgf20EgfFgf7Pak7Nckap1Fgf4EzrPdgfrbSsh3Wasf2Sos1Rac1p2Gna13Cd14ActbArhgef6Raf1PdgfbPak4Bdkrb2Myh10Fgf3Cyfip2F2rFgf23PIP2Cfl1Pak6Cdc42Ssh2Pip5k1bEnahCfl2ActbNrasMapk1Brk1Chrm5Ptk2Rassf7CskActbApcFgf21Abi2PdgfraRdxMsnChrm4Fgfr4RrasPpp1r12aActg1Mapk3Vil1Baiap2Actg1Pip5kl1Ins2Apc2CrkArhgef6Bcar1Diap3Fgfr3Pik3c2gAcetylcholinePip4k2bMyl3Bdkrb1Fgd1Fgf1Pip5k1aChrm1KrasVclPip4k2aFgf6MrasRock2Arhgef7Wasf1Sos2Fgf16PxnPik3c3Gng12Pik3r5Fgf10F2Actn1Slc9a1Pak3Itga1PIP3Pik3r4Fgf8Map2k2BrafPik3r3Pik3c2bChrm2Iqgap1Pfn1Fgf13Rras2Rac3Fgf22Pik3cgPIP2Fgf9MylkFgf18GsnBradykininRac1Fgf5Myl1PdgfaVclPik3cbWasPik3caGit1Rock1Mapk6Fgf14Chrm3Pip4k2cFn1Actg1Ins1Pip5k1cPik3r1Arpc5Pik3r2Pik3cdPfn1Arhgef1Vav1Pik3c2a


Description

A cytoskeleton is a complex, dynamic network of interlinking protein filaments that extends from the cell nucleus to the cell membrane. Actin filaments, composed of the abundant actin protein, are a main component of the cytoskeleton, playing a key role muscle contraction.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP51(r20783) with a 94% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
120790view19:26, 6 January 2022AlexanderPicoModified description
116714view09:56, 11 May 2021EweitzModified title
109403view17:32, 16 March 2020L DupuisConverted interactions to graphical lines
106901view13:37, 17 September 2019MaintBotHMDB identifier normalization
104995view04:25, 28 June 2019Khanspersremoved KEGG comments
71326view17:17, 17 October 2013MaintBotAutomated update of data sources
69146view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67624view11:34, 26 June 2013DdiglesOntology Term : 'cell adhesion signaling pathway' added !
47746view19:30, 5 April 2012Thomasfixed wrongly annotated genes
41334view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
34401view23:01, 9 December 2009MaintBotAutomatic update of empty xrefs
33048view22:09, 7 October 2009MaintBotAdded xrefs
32455view17:23, 15 August 2009MaintBotFixed text labels
32137view13:57, 14 August 2009MaintBotFixed group labels
31168view23:59, 7 August 2009Nsalomoniscleaned up conversion
30894view00:22, 30 July 2009MaintBotConverted from Homo sapiens
21778view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Regulation of Actin Cytoskeleton KEGG]] moved to [[Pathway:WP523]]: Moved to stable identifier
8356view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Regulation of Actin Cytoskeleton KEGG]] moved to [[Pathway:Mus musculus:Regulation of Actin Cytoskeleton KEGG]]: Renaming species
7796view16:18, 18 December 2007MaintBotfixed category names
7290view12:41, 4 November 2007MaintBotAdded categories to GPML
6490view22:19, 22 May 2007169.230.77.174gpml file for [[Mouse:Regulation_of_Actin_Cytoskeleton_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Abi2GeneProduct329165 (Entrez Gene)
AcetylcholineMetaboliteHMDB0000895 (HMDB)
ActbGeneProduct11461 (Entrez Gene)
Actg1GeneProduct11465 (Entrez Gene)
Actn1GeneProduct109711 (Entrez Gene)
ApcGeneProduct11789 (Entrez Gene)
Apc2GeneProduct23805 (Entrez Gene)
Arhgef1GeneProduct16801 (Entrez Gene)
Arhgef4GeneProduct226970 (Entrez Gene)
Arhgef6GeneProduct73341 (Entrez Gene)
Arhgef7GeneProduct54126 (Entrez Gene)
Arpc5GeneProduct67771 (Entrez Gene)
Baiap2GeneProduct108100 (Entrez Gene)
Bcar1GeneProduct12927 (Entrez Gene)
Bdkrb1GeneProduct12061 (Entrez Gene)
Bdkrb2GeneProduct12062 (Entrez Gene)
BradykininMetaboliteHMDB0004246 (HMDB)
BrafGeneProduct109880 (Entrez Gene)
Brk1ProteinQ91VR8 (Uniprot-TrEMBL)
Cd14GeneProduct12475 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
Cfl1GeneProduct12631 (Entrez Gene)
Cfl2GeneProduct12632 (Entrez Gene)
Chrm1GeneProduct12669 (Entrez Gene)
Chrm2GeneProduct243764 (Entrez Gene)
Chrm3GeneProduct12671 (Entrez Gene)
Chrm4GeneProduct12672 (Entrez Gene)
Chrm5GeneProduct213788 (Entrez Gene)
CrkGeneProduct12928 (Entrez Gene)
CskGeneProduct12988 (Entrez Gene)
Cyfip2GeneProduct76884 (Entrez Gene)
Diap1GeneProduct13367 (Entrez Gene)
Diap3GeneProduct56419 (Entrez Gene)
Dock1GeneProduct330662 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
EnahGeneProduct13800 (Entrez Gene)
EzrGeneProduct22350 (Entrez Gene)
F2GeneProduct14061 (Entrez Gene)
F2rGeneProduct14062 (Entrez Gene)
Fgd1GeneProduct14163 (Entrez Gene)
Fgf10GeneProduct14165 (Entrez Gene)
Fgf11GeneProduct14166 (Entrez Gene)
Fgf1GeneProduct14164 (Entrez Gene)
Fgf12GeneProduct14167 (Entrez Gene)
Fgf13GeneProduct14168 (Entrez Gene)
Fgf14GeneProduct14169 (Entrez Gene)
Fgf15GeneProduct14170 (Entrez Gene)
Fgf16GeneProduct80903 (Entrez Gene)
Fgf17GeneProduct14171 (Entrez Gene)
Fgf18GeneProduct14172 (Entrez Gene)
Fgf20GeneProduct80857 (Entrez Gene)
Fgf2GeneProduct14173 (Entrez Gene)
Fgf21GeneProduct56636 (Entrez Gene)
Fgf22GeneProduct67112 (Entrez Gene)
Fgf23GeneProduct64654 (Entrez Gene)
Fgf3GeneProduct14174 (Entrez Gene)
Fgf4GeneProduct14175 (Entrez Gene)
Fgf5GeneProduct14176 (Entrez Gene)
Fgf6GeneProduct14177 (Entrez Gene)
Fgf7GeneProduct14178 (Entrez Gene)
Fgf8GeneProduct14179 (Entrez Gene)
Fgf9GeneProduct14180 (Entrez Gene)
Fgfr1GeneProduct14182 (Entrez Gene)
Fgfr2GeneProduct14183 (Entrez Gene)
Fgfr3GeneProduct14184 (Entrez Gene)
Fgfr4GeneProduct14186 (Entrez Gene)
Fn1GeneProduct14268 (Entrez Gene)
Git1GeneProduct216963 (Entrez Gene)
Gna12GeneProduct14673 (Entrez Gene)
Gna13GeneProduct14674 (Entrez Gene)
Gng12GeneProduct14701 (Entrez Gene)
Grlf1GeneProduct232906 (Entrez Gene)
GsnGeneProduct227753 (Entrez Gene)
Ins1GeneProduct16333 (Entrez Gene)
Ins2GeneProduct16334 (Entrez Gene)
Iqgap1GeneProduct29875 (Entrez Gene)
Itga1GeneProduct109700 (Entrez Gene)
KrasGeneProduct16653 (Entrez Gene)
LPSMetaboliteC00338 (KEGG Compound)
Limk1GeneProduct16885 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk4GeneProduct225724 (Entrez Gene)
Mapk6GeneProduct50772 (Entrez Gene)
MosGeneProduct17451 (Entrez Gene)
MrasGeneProduct17532 (Entrez Gene)
MsnGeneProduct17698 (Entrez Gene)
Myh10GeneProduct77579 (Entrez Gene)
Myl1GeneProduct17901 (Entrez Gene)
Myl3GeneProduct17897 (Entrez Gene)
MylkGeneProduct107589 (Entrez Gene)
Nckap1GeneProduct50884 (Entrez Gene)
NrasGeneProduct18176 (Entrez Gene)
PIP2MetaboliteC04637 (KEGG Compound)
PIP3MetaboliteC05981 (KEGG Compound)
Pak1GeneProduct18479 (Entrez Gene)
Pak2GeneProduct224105 (Entrez Gene)
Pak3GeneProduct18481 (Entrez Gene)
Pak4GeneProduct70584 (Entrez Gene)
Pak6GeneProduct214230 (Entrez Gene)
Pak7GeneProduct241656 (Entrez Gene)
PdgfaGeneProduct18590 (Entrez Gene)
PdgfbGeneProduct18591 (Entrez Gene)
PdgfraGeneProduct18595 (Entrez Gene)
PdgfrbGeneProduct18596 (Entrez Gene)
Pfn1GeneProduct18643 (Entrez Gene)
Pik3c2aGeneProduct18704 (Entrez Gene)
Pik3c2bGeneProduct240752 (Entrez Gene)
Pik3c2gGeneProduct18705 (Entrez Gene)
Pik3c3GeneProduct225326 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Pik3cbGeneProduct74769 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3cgGeneProduct30955 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pik3r3GeneProduct18710 (Entrez Gene)
Pik3r4GeneProduct75669 (Entrez Gene)
Pik3r5GeneProduct320207 (Entrez Gene)
Pip4k2aGeneProduct18718 (Entrez Gene)
Pip4k2bGeneProduct108083 (Entrez Gene)
Pip4k2cGeneProduct117150 (Entrez Gene)
Pip5k1aGeneProduct18720 (Entrez Gene)
Pip5k1bGeneProduct18719 (Entrez Gene)
Pip5k1cGeneProduct18717 (Entrez Gene)
Pip5kl1GeneProduct227733 (Entrez Gene)
Ppp1r12aGeneProduct17931 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene)
PxnGeneProduct19303 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Rac1p2GeneProduct
Rac2GeneProduct19354 (Entrez Gene)
Rac3GeneProduct170758 (Entrez Gene)
Rac4GeneProduct
Raf1GeneProduct110157 (Entrez Gene)
Rassf7GeneProduct66985 (Entrez Gene)
RdxGeneProduct19684 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Rock1GeneProduct19877 (Entrez Gene)
Rock2GeneProduct19878 (Entrez Gene)
RrasGeneProduct20130 (Entrez Gene)
Rras2GeneProduct66922 (Entrez Gene)
Slc9a1GeneProduct20544 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
Sos2GeneProduct20663 (Entrez Gene)
Ssh1GeneProduct231637 (Entrez Gene)
Ssh2GeneProduct237860 (Entrez Gene)
Ssh3GeneProduct245857 (Entrez Gene)
Tmsb4xGeneProduct19241 (Entrez Gene)
Vav1GeneProduct22324 (Entrez Gene)
VclGeneProduct22330 (Entrez Gene)
Vil1GeneProduct22349 (Entrez Gene)
WasGeneProduct22376 (Entrez Gene)
Wasf1GeneProduct83767 (Entrez Gene)
Wasf2GeneProduct242687 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP523"
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