Targeted agents in triple negative breast cancer (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none IRS1PDK1S6KTCS1/2MK2206PIP2dactolisibalpelisibPI3kINPP48AKT1mTORC1PTEN4EBP1MTOReverolimustemsirolimusbuparlisibpictilisibPI3kmTORC2PIP3Name: Relevant molecular pathways and targeted agents in TNBCOrganism: Homo sapiens


Description

Schematic of the most relevant molecular pathways and targeted agents in TNBC. Tyrosine kinase receptor is activated upon binding of growth factors leading to activation of signaling pathways. PI3K/AKT pathway and inhibitor drugs: Phosphorylated PI3K activate AKT. The activation of AKT triggers downstream protein complexes mTORC activation that initiate gene transcription and promote cell growth. AR pathway is activated in LAR subtype tumors. Platinum drugs act through DNA damaging mechanism. PARP inhibitors induce “synthetic lethality” in BRCA deficient tumors.

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Cell Type : hepatocyte
 

Bibliography

  1. Vagia E, Mahalingam D, Cristofanilli M; ''The Landscape of Targeted Therapies in TNBC.''; Cancers (Basel), 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137704
Approved
view11:26, 7 March 2025EweitzAlign interactions, refine layering
137703view11:24, 7 March 2025EweitzEconomize layout
137702view11:19, 7 March 2025EweitzEconomize layout
137701view11:13, 7 March 2025EweitzStandardize case
137657view12:16, 6 March 2025EweitzStack nodes
137656view12:14, 6 March 2025EweitzTailor node width
137655view12:08, 6 March 2025EweitzTailor node height
137631view21:49, 5 March 2025KhanspersModified description
135833view13:42, 15 November 2024EweitzOntology Term : 'breast cancer pathway' added !
135832view13:36, 15 November 2024EweitzModified title
135288view18:02, 14 August 2024Khansperslayout, xrefs
134125view01:07, 29 June 2024Khanspersadded mapk signaling arm, cell and nucleus, mTORC complexes
134025view23:49, 12 June 2024KhanspersModified description
134024view23:47, 12 June 2024KhanspersModified title
134023view23:47, 12 June 2024Khansperscleanup: added xrefs, improve layout
134020view23:30, 12 June 2024KhanspersOntology Term : 'altered signaling pathway' added !
134019view23:29, 12 June 2024KhanspersOntology Term : 'triple-receptor negative breast cancer' added !
122330view12:36, 18 March 2022AndraNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
4EBP1GeneProduct
AKT1GeneProduct207 (Entrez Gene)
INPP48GeneProduct
IRS1GeneProduct3667 (Entrez Gene)
MK2206Metabolite
MTORGeneProduct2475 (Entrez Gene)
PDK1GeneProduct5163 (Entrez Gene)
PI3kGeneProduct
PIP2 GeneProduct
PIP3GeneProduct
PTENGeneProduct5728 (Entrez Gene)
S6KGeneProduct
TCS1/2GeneProduct
alpelisibMetaboliteQ27074391 (Wikidata)
buparlisibMetaboliteQ25100534 (Wikidata)
dactolisibMetaboliteQ4835503 (Wikidata)
everolimusMetaboliteQ421052 (Wikidata)
mTORC1GeneProduct
mTORC2GeneProduct
pictilisibMetaboliteQ27088388 (Wikidata)
temsirolimusMetaboliteQ7699074 (Wikidata)

Annotated Interactions

No annotated interactions

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