Thyroid hormone imbalance leading to neurodevelopmental abnormalities (Homo sapiens)

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Thyroid hormone biosynthesis pathwayKE279: Thyroperoxidase inhibition KE424: NIS inhibition Thyroid hormone biosynthesis pathwayKE277: Decrease thyroid hormone synthesis Thyroid hormone biosynthesis pathwayKE425: Decrease of Thyroidal IodidePathwayKE281:Decreased T4 in serumKE381:Reduced levels of BDNF PathwayPathwayKE280:Decreased T4 in neuronal tissue CaMKK2 signaling pathwayKE756:Altered hippocampal gene expression CaMKK2 signaling pathwayKE851: Decreased GABAergic interneurons PathwayKE757: Altered hippocampal anatomy KE758: Altered hippocampal physiology PathwayPathwayKE385: Decreased synaptogenesis KE386: Decreased neuronal network functionPathwayPathwayPathwayKE341: Learning and memory impairment KE42: Decreased cognitive function PathwayKE319: loss of cochlear functionPathway


Description

Adverse Outcome Pathway for the effect of thyroid hormone disruption

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Quality Tags

Ontology Terms

 

Bibliography

  1. Sauer UG, Asiimwe A, Botham PA, Charlton A, Hallmark N, Jacobi S, Marty S, Melching-Kollmuss S, Palha JA, Strauss V, van Ravenzwaay B, Swaen G; ''Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments?''; Crit Rev Toxicol, 2020 PubMed Europe PMC Scholia
  2. Marty S, Beekhuijzen M, Charlton A, Hallmark N, Hannas BR, Jacobi S, Melching-Kollmuss S, Sauer UG, Sheets LP, Strauss V, Urbisch D, Botham PA, van Ravenzwaay B; ''Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?''; Crit Rev Toxicol, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134542view21:16, 22 July 2024EweitzOntology Term : 'oligodendrocyte' added !
134541view21:16, 22 July 2024EweitzOntology Term : 'GABAergic interneuron' added !
134540view21:15, 22 July 2024EweitzOntology Term : 'thyroid hormone biosynthetic pathway' added !
134539view18:35, 22 July 2024EgonwFixed a datasource
128159view17:07, 28 January 2024EweitzModified description
128158view17:06, 28 January 2024EweitzRefine node padding, add space after colons, standardize case
128157view17:02, 28 January 2024EweitzModified title
127806view21:23, 17 December 2023Marvin M2Modified description
127805view21:22, 17 December 2023Marvin M2
127804view21:18, 17 December 2023Marvin M2graphical updates
127291view14:34, 4 September 2023Marvin M2Updated layout, added chain of KEs
126475view17:27, 4 May 2023CMalyarModified title
125574view13:23, 28 February 2023Marvin M2Added references
125573view13:19, 28 February 2023Marvin M2Ontology Term : 'thyroid hormone signaling pathway' added !
124846view21:03, 14 December 2022EweitzModified title
124834view19:38, 13 December 2022Marvin M2
124833view19:36, 13 December 2022Marvin M2alignment changes
122991view13:39, 10 June 2022CMalyarFixed interactions
122990view14:06, 9 June 2022CMalyarPathway interactions fixed
122989view14:04, 9 June 2022CMalyarFixed interaction arrows
122983view08:01, 9 June 2022CMalyarManual identifiers of key events from AOP-Wiki
122980view20:03, 8 June 2022CMalyarFixed pathway identifiers
122979view19:57, 8 June 2022CMalyarStructural changes
122671view07:59, 29 April 2022CMalyar
122655view12:58, 26 April 2022CMalyar
122654view11:03, 26 April 2022CMalyarNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CaMKK2 signaling pathwayPathway
KE277: Decrease thyroid hormone synthesis
KE279: Thyroperoxidase inhibition
KE280:Decreased T4 in neuronal tissue
KE281:Decreased T4 in serum
KE319: loss of cochlear function
KE341: Learning and memory impairment
KE381:Reduced levels of BDNF
KE385: Decreased synaptogenesis
KE386: Decreased neuronal network function
KE424: NIS inhibition
KE425: Decrease of Thyroidal Iodide
KE42: Decreased cognitive function
KE756:Altered hippocampal gene expression
KE757: Altered hippocampal anatomy
KE758: Altered hippocampal physiology
KE851: Decreased GABAergic interneurons
PathwayPathway
Thyroid hormone biosynthesis pathwayPathway
Thyroid hormone biosynthesis pathway Pathway

Annotated Interactions

No annotated interactions

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