p53 transcriptional gene network (Homo sapiens)

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1-3mTORC1AMPKE2F7TP53I3CDC25AFASLGPRKAA2PRKAA1MIR34ATP53I3AURKAPCNAMIR34CAKT1S1APAF1AutophagyMIR34ARPTORp53 transcriptional regulationCDC25CSFNMLST8DEPTORTSC2PRKAG2TNFRSF10BCDK2DDIT4PRKAG3CCNE1TNFApoptosisSCO2MTORPRKAG1TP53I3Cell Cycle ArrestSenescenceDNA RepairFerroptosisMetabolismStem Cell FunctionTMEInvasion/MetastasisBAXFASMIR34APMAIP1TP53AIP1TRAF4PERPPIDD1TP53I3BBC3SIVA1TNFRSF10DYWHAB-208BTG2CCNG1CDKN1AGADD45AMIR34AMIR34BSMR3BRPRMZMAT3CDKN1ASERPINE1PMLDDB2ERCC5FANCCGADD45AXRCC5MGMTMLH1MSH2POLHPOLKRRM2BXPCSAT1SLC7A11GLS2CDKN1AMIR34AMIR200CSERPINB5CDKN1ALIFMIR34AMIR34B/CMIR145NANOGNOTCH1ACAD11ADORA2BALDH4A1CPT1CDRAM1FUCA1GLS2SLC2A1GPX1PRKAB1PRKAB2PTENSESN1SESN2TIGARTP53INP1ULK1ULK2ADGRB1CX3CL1ICAM1IRF5IRF9ISG15SERPINB5CCL2NCF2SERPINE1THBS1ULBP1ULBP2MIR34C


Description

The mechanisms underlying p53 tumor-suppressor function as gleaned from mouse models of genetic disruption to p53, its regulators and its targets (Kaiser 2017).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Levine AJ; ''p53: 800million years of evolutionand 40 years of discovery.''; Nat Rev Cancer, 2020 PubMed Europe PMC Scholia
  2. Kaiser AM, Attardi LD; ''Deconstructing networks of p53-mediated tumor suppression in vivo.''; Cell Death Differ, 2018 PubMed Europe PMC Scholia
  3. Hernández Borrero LJ, El-Deiry WS; ''Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting.''; Biochim Biophys Acta Rev Cancer, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134604view01:35, 23 July 2024EweitzStandardize case
127862view22:51, 2 January 2024AlexanderPicoSeparate MIR34B and C as independent datanodes
127860view22:37, 2 January 2024AlexanderPicoReverted to version '07:54, 2 May 2022' by AlexanderPico
127853view07:37, 1 January 2024%(^Modified title
122690view14:54, 2 May 2022JuliajohnssonAdded more genes and one pathway.
112233view17:48, 5 October 2020Khanspersadded identifiers to pathway nodes and updated color
112232view17:41, 5 October 2020KhanspersOntology Term : 'p53 signaling pathway' added !
112231view17:39, 5 October 2020Khanspersupdated literature reference format
111434view19:08, 9 August 2020AlexanderPicoModified description
111433view18:57, 9 August 2020AlexanderPicointeractions to graphical lines
111432view18:56, 9 August 2020AlexanderPicoidentified human orthologs; split MIR34B/C into two datanodes
111431view08:55, 8 August 2020EgonwFixed the Ensembl data source.
111412view05:08, 7 August 2020DiazfloreseModified title
111411view00:36, 7 August 2020DaisydxNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACAD11GeneProductENSG00000240303 (Ensembl)
ADGRB1GeneProductENSG00000181790 (Ensembl)
ADORA2BGeneProductENSG00000170425 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
ALDH4A1GeneProductENSG00000159423 (Ensembl)
APAF1GeneProductENSG00000120868 (Ensembl)
AURKAGeneProductENSG00000087586 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl)
BTG2GeneProductENSG00000159388 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCNE1GeneProductENSG00000105173 (Ensembl)
CCNG1GeneProductENSG00000113328 (Ensembl)
CDC25AProteinC9JH94 (Uniprot-TrEMBL)
CDC25CGeneProductENSG00000158402 (Ensembl)
CDK2GeneProductENSG00000123374 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CPT1CGeneProductENSG00000169169 (Ensembl)
CX3CL1GeneProductENSG00000006210 (Ensembl)
Cell Cycle ArrestPathway
DDB2GeneProductENSG00000134574 (Ensembl)
DDIT4GeneProductENSG00000168209 (Ensembl)
DEPTORGeneProductENSG00000155792 (Ensembl)
DNA RepairPathwayWP4946 (WikiPathways)
DRAM1GeneProductENSG00000136048 (Ensembl)
E2F7GeneProductENSG00000165891 (Ensembl)
ERCC5GeneProductENSG00000134899 (Ensembl)
FANCCGeneProductENSG00000158169 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FUCA1GeneProductENSG00000179163 (Ensembl)
FerroptosisPathwayWP4313 (WikiPathways)
GADD45AGeneProductENSG00000116717 (Ensembl)
GLS2GeneProductENSG00000135423 (Ensembl)
GPX1GeneProductENSG00000233276 (Ensembl)
ICAM1GeneProductENSG00000090339 (Ensembl)
IRF5GeneProductENSG00000128604 (Ensembl)
IRF9GeneProductENSG00000213928 (Ensembl)
ISG15GeneProductENSG00000187608 (Ensembl)
Invasion/MetastasisPathway
LIFGeneProductENSG00000128342 (Ensembl)
MGMTGeneProductENSG00000170430 (Ensembl)
MIR145GeneProductENSG00000276365 (Ensembl)
MIR200CGeneProductENSG00000207713 (Ensembl)
MIR34AGeneProductENSG00000284357 (Ensembl)
MIR34B/CGeneProductENSG00000207811/ENSG00000207562 (Ensembl)
MIR34BGeneProductENSG00000207811 (Ensembl)
MIR34CGeneProductENSG00000207562 (Ensembl)
MLH1GeneProductENSG00000076242 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MetabolismPathway
NANOGGeneProductENSG00000111704 (Ensembl)
NCF2GeneProductENSG00000116701 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
PCNAGeneProductENSG00000132646 (Ensembl)
PERPGeneProductENSG00000112378 (Ensembl)
PIDD1GeneProductENSG00000177595 (Ensembl)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PMLGeneProductENSG00000140464 (Ensembl)
POLHGeneProductENSG00000170734 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
RPRMGeneProductENSG00000177519 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
RRM2BGeneProductENSG00000048392 (Ensembl)
SAT1GeneProductENSG00000130066 (Ensembl)
SCO2GeneProductENSG00000284194 (Ensembl)
SERPINB5GeneProductENSG00000206075 (Ensembl)
SERPINE1GeneProductENSG00000106366 (Ensembl)
SESN1GeneProductENSG00000080546 (Ensembl)
SESN2GeneProductENSG00000130766 (Ensembl)
SFNGeneProductENSG00000175793 (Ensembl)
SIVA1GeneProductENSG00000184990 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
SMR3BGeneProductENSG00000171201 (Ensembl)
SenescencePathway
Stem Cell FunctionPathway
THBS1GeneProductENSG00000137801 (Ensembl)
TIGARGeneProductENSG00000078237 (Ensembl)
TMEPathway
TNFGeneProductENSG00000232810 (Ensembl)
TNFRSF10BGeneProductENSG00000120889 (Ensembl)
TNFRSF10DGeneProductENSG00000173530 (Ensembl)
TP53AIP1GeneProductENSG00000120471 (Ensembl)
TP53I3GeneProductENSG00000115129 (Ensembl)
TP53INP1GeneProductENSG00000164938 (Ensembl) mouse ortholog: Trp53inp1
TRAF4GeneProductENSG00000076604 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
ULBP1GeneProductENSG00000111981 (Ensembl)
ULBP2GeneProductENSG00000131015 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
XPCGeneProductENSG00000154767 (Ensembl)
XRCC5GeneProductENSG00000079246 (Ensembl)
YWHAB-208GeneProductENST00000633979 (Ensembl)
ZMAT3GeneProductENSG00000172667 (Ensembl)
p53 transcriptional regulationPathway

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4963"
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