Estradiol regulation in porto-sinusoidal vascular disease (Homo sapiens)

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1Smooth muscle regulationEstradiolCALM1SP3Ca2+SP1ERαSK3 channelKCNN32, 4, 5XTranscription Factors


Description

Under construction. Genetic elements found to be related to idiopathic non-cirrhotic portal hypertension (INCPH).

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Ontology Terms

 

Bibliography

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  1. Gu M, Zhu Y, Yin X, Zhang DM; ''Small-conductance Ca2+-activated K+channels: insights into their roles in cardiovascular disease.''; Exp Mol Med, 2018 PubMed Europe PMC Scholia
  2. Griffon N, Schuers M, Dhombres F, Merabti T, Kerdelhué G, Rollin L, Darmoni SJ; ''Searching for rare diseases in PubMed: a blind comparison of Orphanet expert query and query based on terminological knowledge.''; BMC Med Inform Decis Mak, 2016 PubMed Europe PMC Scholia
  3. Schouten JN, Verheij J, Seijo S; ''Idiopathic non-cirrhotic portal hypertension: a review.''; Orphanet J Rare Dis, 2015 PubMed Europe PMC Scholia
  4. Morikawa H, Morrisett RA; ''Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs.''; Int Rev Neurobiol, 2010 PubMed Europe PMC Scholia
  5. Schouten JN, Garcia-Pagan JC, Valla DC, Janssen HL; ''Idiopathic noncirrhotic portal hypertension.''; Hepatology, 2011 PubMed Europe PMC Scholia
  6. Taylor MS, Bonev AD, Gross TP, Eckman DM, Brayden JE, Bond CT, Adelman JP, Nelson MT; ''Altered expression of small-conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure.''; Circ Res, 2003 PubMed Europe PMC Scholia
  7. Weisbrod D; ''Small and Intermediate Calcium Activated Potassium Channels in the Heart: Role and Strategies in the Treatment of Cardiovascular Diseases.''; Front Physiol, 2020 PubMed Europe PMC Scholia
  8. Ledoux J, Werner ME, Brayden JE, Nelson MT; ''Calcium-activated potassium channels and the regulation of vascular tone.''; Physiology (Bethesda), 2006 PubMed Europe PMC Scholia
  9. Besmond C, Valla D, Hubert L, Poirier K, Grosse B, Guettier C, Bernard O, Gonzales E, Jacquemin E; ''Mutations in the novel gene FOPV are associated with familial autosomal dominant and non-familial obliterative portal venopathy.''; Liver Int, 2018 PubMed Europe PMC Scholia
  10. Sith Siramolpiwat, Susana Seijo; ''Idiopathic non-cirrhotic portal hypertension''; Journal of Rare Diseases Research & Treatment, 2016
  11. Köhler M, Hirschberg B, Bond CT, Kinzie JM, Marrion NV, Maylie J, Adelman JP; ''Small-conductance, calcium-activated potassium channels from mammalian brain.''; Science, 1996 PubMed Europe PMC Scholia
  12. Jacobson D, Pribnow D, Herson PS, Maylie J, Adelman JP; ''Determinants contributing to estrogen-regulated expression of SK3.''; Biochem Biophys Res Commun, 2003 PubMed Europe PMC Scholia
  13. Köhler R, Ruth P; ''Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice.''; Pflugers Arch, 2010 PubMed Europe PMC Scholia
  14. Koot BG, Alders M, Verheij J, Beuers U, Cobben JM; ''A de novo mutation in KCNN3 associated with autosomal dominant idiopathic non-cirrhotic portal hypertension.''; J Hepatol, 2016 PubMed Europe PMC Scholia
  15. Lee H, Rehman AU, Fiel MI; ''Idiopathic Noncirrhotic Portal Hypertension: An Appraisal.''; J Pathol Transl Med, 2016 PubMed Europe PMC Scholia
  16. Pierce SL, England SK; ''SK3 channel expression during pregnancy is regulated through estrogen and Sp factor-mediated transcriptional control of the KCNN3 gene.''; Am J Physiol Endocrinol Metab, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135156view00:03, 7 August 2024EweitzClear cache to fix board height
135155view00:02, 7 August 2024EweitzEconomize layout
135154view23:58, 6 August 2024EweitzEconomize layout
135153view23:56, 6 August 2024EweitzEconomize layout
127926view18:47, 17 January 2024Khanspersdecreased board height
127925view18:45, 17 January 2024Khanspersdecreased board height
127924view04:57, 17 January 2024EweitzTrim diagram perimeter margin, deconvolute Apamin interaction
127923view04:51, 17 January 2024EweitzEconomize layout
127922view04:33, 17 January 2024EweitzFix typo (smoot -> smooth), standardize case
127921view04:31, 17 January 2024EweitzFix misnamed gene: ER1 -> ESR1
127920view04:27, 17 January 2024EweitzOntology Term : 'vascular associated smooth muscle cell' added !
127919view04:25, 17 January 2024EweitzOntology Term : 'endothelial cell' added !
127480view14:02, 8 October 2023LarsgwUpdate DataNode annotations
127479view13:58, 8 October 2023EgonwChEBI id for K+ instead of the "K" atom
123952view11:31, 7 September 2022EweitzModified description
123951view11:27, 7 September 2022EweitzModified title
123627view08:25, 7 August 2022EgonwModified title
123338view19:27, 16 July 2022AlexanderPicoOntology Term : 'hypertension pathway' added !
123337view19:27, 16 July 2022AlexanderPicoOntology Term : 'vascular disease' added !
123336view19:25, 16 July 2022AlexanderPicoModified description
123084view15:33, 27 June 2022ChristeldeVriesChanged display name of ERα into ER1
123081view07:22, 27 June 2022ChristeldeVriesModified title
123077view10:31, 24 June 2022ChristeldeVriesAnnotation added
123076view10:25, 24 June 2022FehrhartOntology Term : 'disease pathway' added !
123075view10:25, 24 June 2022FehrhartOntology Term : 'portal hypertension' added !
123073view10:14, 24 June 2022ChristeldeVriesModified description
123072view10:12, 24 June 2022ChristeldeVriesModified description
123071view10:10, 24 June 2022ChristeldeVriesAdded and updated references
122897view14:27, 30 May 2022ChristeldeVriesModified title
122895view10:56, 30 May 2022ChristeldeVriesModified description
122894view10:56, 30 May 2022ChristeldeVriesModified description
122893view10:55, 30 May 2022ChristeldeVriesModified description
122892view10:54, 30 May 2022ChristeldeVriesModified description
122883view10:35, 28 May 2022ChristeldeVriesRemoved Enhancer and Promoter
122882view09:38, 28 May 2022ChristeldeVriesAdjusted LayOut
122881view09:25, 28 May 2022ChristeldeVriesUpdated Annotation
122872view16:00, 27 May 2022ChristeldeVriesUpdated interactions SP1, SP3, ERalpha
122861view11:33, 25 May 2022ChristeldeVriesReorganisation
122860view07:17, 25 May 2022ChristeldeVriesReorganisation
122810view09:34, 20 May 2022ChristeldeVriesChange visualisation of gene stimulation
122807view06:08, 19 May 2022ChristeldeVriesAdded probable genetic component
122776view11:53, 13 May 2022ChristeldeVriesUpdated references
122764view11:43, 12 May 2022ChristeldeVriesNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CALM1ProteinP0DP23 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
ERαProteinP03372 (Uniprot-TrEMBL)
EstradiolMetaboliteCHEBI:16469 (ChEBI)
KCNN3GeneProductENSG00000143603 (Ensembl)
SK3 channelProteinQ9UGI6 (Uniprot-TrEMBL) Also referred to as:

Small-conductance Ca2+- activated K+ (SK) channel Small conductance calcium-activated potassium channel protein 3 SK3 channel SKCa 3

About: The SK3 channel is important for afterhyperpolarization following an action potential. SK3 channels consist of six transmembrane segments that are connected via a single pore loop. The N-termini and the C-termini are both located at the intracellular side of the membrane. A calmodulin molecule is located at the C-termini of the SK3 channel via a CaM-binding domain. Calmodulin will activate the SK3 channel upon binding of Ca2+. SK3 channels are voltage-independent. (Gu et al. 2018; Köhler et al. 1996; Weisbrod, 2020)

SP1ProteinP08047 (Uniprot-TrEMBL)
SP3ProteinQ02447 (Uniprot-TrEMBL)
Smooth muscle regulation

Annotated Interactions

No annotated interactions

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