Notch signaling pathway (Anopheles gambiae)

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1gene expressionDNAg-secretasecomplexMAPK signaling pathwayS2Ras/Mapco-repressor complexS3NICDNotch Intracellular DomainNOTCH2NCSTNPCAFGCN5L2DTX2TNFHDAC2DTX3DVL1CREBBPJAG2NUMBPTCRARBPSUHLNUMBLPSEN1DTX1ADAM17HDAC1DVL3DLL3JAG1MAML3CTBP2DVL2DLL1DTX4SKIPNOTCH3HES5APH1BMFNGNCOR2LFNGPSEN2NOTCH4DTX3LAPH1AAgaP_AGAP001283MAML1RFNGNOTCH1HES1CTBP1DLL4AgaP_AGAP008935


Description

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.

Source: KEGG

Adapted from KEGG: http://www.genome.jp/kegg-bin/show_pathway?org_name=ecb&mapno=04330

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP268(r29891) with a 80% conversion rate.

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Ontology Terms

 

Bibliography

  1. Weinmaster G; ''The ins and outs of notch signaling.''; Mol Cell Neurosci, 1997 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
122785view23:29, 17 May 2022AlexanderPicocleaning up broken comments
117223view09:30, 19 May 2021EweitzModified title
68448view19:22, 5 July 2013MaintBotUpdated to 2013 gpml schema
67521view11:20, 26 June 2013DdiglesOntology Term : 'Notch signaling pathway' added !
58808view23:00, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40481view18:47, 1 March 2011MaintBotRemoved redundant pathway information and comments
35627view16:10, 12 February 2010Thomasadded literature
35625view16:09, 12 February 2010ThomasModified description
32287view13:10, 15 August 2009MaintBotFixed text labels
31839view12:29, 14 August 2009MaintBotFixed group labels
31315view20:15, 13 August 2009MaintBotFixed text labels
30801view23:45, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM17GeneProductAGAP002381 (Ensembl)
APH1AGeneProductAGAP009816 (Ensembl)
APH1BGeneProductAGAP009816 (Ensembl)
AgaP_AGAP001283GeneProduct1281896 (Entrez Gene)
AgaP_AGAP008935GeneProduct1279906 (Entrez Gene)
CREBBPGeneProductAGAP000029 (Ensembl)
CTBP1GeneProductAGAP003893 (Ensembl)
CTBP2GeneProductAGAP003893 (Ensembl)
DLL1GeneProductAGAP010265 (Ensembl)
DLL3GeneProduct
DLL4GeneProductAGAP010265 (Ensembl)
DTX1GeneProductAGAP000903 (Ensembl)
DTX2GeneProductAGAP000903 (Ensembl)
DTX3GeneProductAGAP000903 (Ensembl)
DTX3LGeneProductAGAP000903 (Ensembl)
DTX4GeneProductAGAP000903 (Ensembl)
DVL1GeneProductAGAP004448 (Ensembl)
DVL2GeneProductAGAP004448 (Ensembl)
DVL3GeneProductAGAP004448 (Ensembl)
GCN5L2GeneProductAGAP004434 (Ensembl)
HDAC1GeneProductAGAP006511 (Ensembl)
HDAC2GeneProductAGAP006511 (Ensembl)
HES1GeneProduct
HES5GeneProduct
JAG1GeneProductAGAP004154 (Ensembl)
JAG2GeneProductAGAP004154 (Ensembl)
LFNGGeneProductAGAP006439 (Ensembl)
MAML1GeneProduct
MAML3GeneProduct
MFNGGeneProductAGAP006439 (Ensembl)
NCOR2GeneProduct
NCSTNGeneProductAGAP001734 (Ensembl)
NOTCH1GeneProductAGAP001015 (Ensembl)
NOTCH2GeneProductAGAP001015 (Ensembl)
NOTCH3GeneProductAGAP001015 (Ensembl)
NOTCH4GeneProductAGAP003873 (Ensembl)
NUMBGeneProductAGAP010167 (Ensembl)
NUMBLGeneProductAGAP010167 (Ensembl)
PCAFGeneProductAGAP004434 (Ensembl)
PSEN1GeneProductAGAP002957 (Ensembl)
PSEN2GeneProductAGAP002957 (Ensembl)
PTCRAGeneProduct
RBPSUHLGeneProduct
RFNGGeneProductAGAP006439 (Ensembl)
SKIPGeneProductAGAP011644 (Ensembl)
TNFGeneProduct

Annotated Interactions

No annotated interactions
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