Lac-Phe pathway (Homo sapiens)

Revision as of 08:37, 18 June 2022 by Egonw (Talk | contribs)

Description

Lac-Phe is formed by CNDP2 and exported outside the cell, into the blood circulation by ABCC5. It is linked to food intake and obesity.

View approved pathways at the new wikipathways.org.

Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, Tanzo JT, Tung AS, Lyu X, Zushin PH, Jansen RS, Michael B, Loh KY, Yang AC, Carl CS, Voldstedlund CT, Wei W, Terrell SM, Moeller BC, Arthur RM, Wallis GA, van de Wetering K, Stahl A, Kiens B, Richter EA, Banik SM, Snyder MP, Xu Y, Long JZ; ''An exercise-inducible metabolite that suppresses feeding and obesity.''; Nature, 2022 PubMed Europe PMC Scholia
Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, Altelaar M, IJlst L, Wanders RJ, Borst P, van de Wetering K; ''N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.''; Proc Natl Acad Sci U S A, 2015 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
139982	view	05:04, 15 July 2025	Egonw	Removed duplicate BioPax fields
139966	view	17:21, 13 July 2025	Egonw	Complete info for the references
123034	view	07:06, 20 June 2022	Egonw	Removed RHEA:
123027	view	08:38, 18 June 2022	Egonw	Ontology Term : 'classic metabolic pathway' added !
123026	view	08:38, 18 June 2022	Egonw	Modified description
123024	view	08:37, 18 June 2022	Egonw	Ontology Term : 'signaling pathway' added !
123023	view	08:37, 18 June 2022	Egonw	Ontology Term : 'obesity pathway' added !
123021	view	08:36, 18 June 2022	Egonw	Modified description
123017	view	06:59, 18 June 2022	Egonw	New pathway

Name	Type	Database reference
(S)-lactate	Metabolite	16651 (ChEBI)
ABCC5	GeneProduct	O15440 (Uniprot-TrEMBL)
CNDP2	Protein	Q96KP4 (Uniprot-TrEMBL)
L-phenylalanine	Metabolite	58095 (ChEBI)
Lac-Phe	Metabolite	167456 (ChEBI)

Source	Target	Type	Database reference	Comment
(S)-lactate	Lac-Phe	mim-conversion	RHEA:66724 (Rhea)
Lac-Phe	Lac-Phe		RHEA:66720 (Rhea)