Lac-Phe pathway (Homo sapiens)

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1, 22Lac-PheL-phenylalanineABCC5CNDP2(S)-lactateLac-Phe


Description

Lac-Phe is formed by CNDP2 and exported outside the cell, into the blood circulation by ABCC5. It is linked to food intake and obesity, where it is increased after exercise and suppresses food intake.

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Ontology Terms

 

Bibliography

  1. Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, Tanzo JT, Tung AS, Lyu X, Zushin PH, Jansen RS, Michael B, Loh KY, Yang AC, Carl CS, Voldstedlund CT, Wei W, Terrell SM, Moeller BC, Arthur RM, Wallis GA, van de Wetering K, Stahl A, Kiens B, Richter EA, Banik SM, Snyder MP, Xu Y, Long JZ; ''An exercise-inducible metabolite that suppresses feeding and obesity.''; Nature, 2022 PubMed Europe PMC Scholia
  2. Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, Altelaar M, IJlst L, Wanders RJ, Borst P, van de Wetering K; ''N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.''; Proc Natl Acad Sci U S A, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139982view05:04, 15 July 2025EgonwRemoved duplicate BioPax fields
139966view17:21, 13 July 2025EgonwComplete info for the references
123034view07:06, 20 June 2022EgonwRemoved RHEA:
123027view08:38, 18 June 2022EgonwOntology Term : 'classic metabolic pathway' added !
123026view08:38, 18 June 2022EgonwModified description
123024view08:37, 18 June 2022EgonwOntology Term : 'signaling pathway' added !
123023view08:37, 18 June 2022EgonwOntology Term : 'obesity pathway' added !
123021view08:36, 18 June 2022EgonwModified description
123017view06:59, 18 June 2022EgonwNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
(S)-lactateMetabolite16651 (ChEBI)
ABCC5GeneProductO15440 (Uniprot-TrEMBL)
CNDP2ProteinQ96KP4 (Uniprot-TrEMBL)
L-phenylalanineMetabolite58095 (ChEBI)
Lac-PheMetabolite167456 (ChEBI)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
(S)-lactateLac-Phemim-conversion66724 (Rhea)
Lac-PheLac-Phe66720 (Rhea)
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