SARS-CoV-2 envelope lipid composition and human cell binding (Homo sapiens)

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112human cellmostlyOuter leafletVirionEnvelopeMembraneprocoagulantaminophospholipidphosphatidyl-L-serinecholesterolPhospholipidsAXLBloodclothingsphingolipidssomesomeInner leafletphosphatidyl-ethanolamineAbundance:


Description

This pathway captures the finding of Saud et al. that it is the virion membrane that is an active participant in the cellular uptake of the SARS-CoV-2 virion. Results show the lipid composition of the virion membrane to resembled that of human cell organel membranes, rather than the cell membrane itself.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Saud Z, Tyrrell VJ, Zaragkoulias A, Protty MB, Statkute E, Rubina A, Bentley K, White DA, Rodrigues PDS, Murphy RC, Köfeler H, Griffiths WJ, Alvarez-Jarreta J, Brown RW, Newcombe RG, Heyman J, Pritchard M, Mcleod RW, Arya A, Lynch CA, Owens D, Jenkins PV, Buurma NJ, O'Donnell VB, Thomas DW, Stanton RJ; ''The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses.''; J Lipid Res, 2022 PubMed Europe PMC Scholia
  2. Bohan D, Van Ert H, Ruggio N, Rogers KJ, Badreddine M, Aguilar Briseño JA, Elliff JM, Rojas Chavez RA, Gao B, Stokowy T, Christakou E, Kursula P, Micklem D, Gausdal G, Haim H, Minna J, Lorens JB, Maury W; ''Phosphatidylserine receptors enhance SARS-CoV-2 infection.''; PLoS Pathog, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123355view14:18, 17 July 2022EgonwModified title
123354view14:03, 17 July 2022EgonwOntology Term : 'COVID-19' added !
123353view14:03, 17 July 2022EgonwOntology Term : 'disease pathway' added !
123352view14:01, 17 July 2022EgonwModified description
123351view13:19, 17 July 2022EgonwMade a pathway clickable
123247view06:32, 7 July 2022EgonwAdded details of the role of the envelope in cell uptake.
123219view14:09, 5 July 2022EgonwConfirmed the two are sPLs
123216view14:04, 5 July 2022EgonwExplain what the qualifiers mean
123213view14:03, 5 July 2022EgonwAdded details from the conclusions
123211view13:50, 5 July 2022EgonwAdded more knowledge from the abstract
123207view13:34, 5 July 2022EgonwAdded the main components as listed in the abstract
123206view13:23, 5 July 2022EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AXLGeneProductENSG00000167601 (Ensembl)
Blood clothingPathwayWP4927 (WikiPathways)
PhospholipidsMetabolite16247 (ChEBI)
cholesterolMetabolite16113 (ChEBI)
phosphatidyl- ethanolamineMetabolite16038 (ChEBI)
phosphatidyl-L-serineMetabolite18303 (ChEBI)
procoagulant aminophospholipidMetabolite60971 (ChEBI)
sphingolipidsMetabolite26739 (ChEBI)

Annotated Interactions

No annotated interactions

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