DDR1-mediated signaling (Homo sapiens)

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Cancer progression and metastasisDDR1 over expressionTumor growth, invasion, and metastasis in BxPC3 cellsEpithelial Mesenchymal TransitionBreast cancerGastric cancerTumor invasionThyroid cancermiR-199a-5p27LNcap FGC and DU 145Colorectal cancerCell migration and invasionMTOR26S2448S2481MAPK148IL1B8CDK6Reduce migrationRAP1GAPCOL4A14FOSL19MAPK317PAKT1S47326T308VIM118ChemoresistanceCXCL88DDR1INSR29, 30Y7402MMP97Cell cycle arrest and apoptosis MAPK96, 23Cell migrationZEB1DDR12527DDR1Y792CTNNB19BCR9Y177NFKB1A6, 23PTK2B4Y579Y580TM4SF115ActivationNFKB18IGF2VCAM119DDR17CDK1INSRDDR115ACTB20COL111MAPK3MYH220MAPK1MAPK319AKT1T202MAPK119T2022COLA1Prostate cancer4CD406PYK2Apoptosis18COLA1Cancer invasion26MMP9DDR1Y7921CCL38PCLAFPancreatic cancerDDR1Y51326RELA6, 23COL4A1PTK220CDH14Y57711CDKN1AAKT127S473PEAK11Y665MYH220BCAR14COLA1MTORS244815PCA-110DDR111Epithelial Mesenchymal TransitionJUN4MAPK1P22COLA113NOS26, 23CD929DDR1Y79214BIK 24NCK230Chemoresistance and tumor progressionMAPK17HMGA1MKI67COL4A1257DDR1DDR1257MAPK115T160MMP96MAP2K7EMT-inducing transcription factors in bladder cancer4COLA1Bladder cancer20IGF-1MYC59MMP9IGF2105DDR1MAPK357Y792INSRPTGS2IGF1R565COLA13, 16, 21PTK2BCOLA151BECN126CDH122AKT1S4732IKBKB29MAPK8Cell motility in 5637 cells and T24T bladder cancer cells4IGF127PTK2BY402Non small cell lung cancer1MYH920CDH24SEC61B20COLA19DDR122SP1Other type of cancersTP53COLA18COLA1Pituitary adenocarcinoma and hepatocellular carcinoma6, 23SRC 1A375 melanoma, HT29 colon carcinoma and SK-HEP hepatoma cellsMAPK86, 23CCL28CDH213DDR18PTK2BCell invasion13Y402SHC1CTNNB113CDH2918COLA114MAPK146, 23AKT17DDR1Y51313MAP3K114JUN9Cell invasionACTB20COLA1DDR1122Y792MMP225AKT115S473Skin cancerIGF1RCell migration27DDR118PPTK2BY402VIM1422CDH114DDR16, 23MAP2K7P18DDR110COLA1Epithelial-mesenchymal transition (EMT) 7BCL2L110PTPN1130MMP2MMP911PTGS229PARD6ARegulates cell differentiation12DDR130T34Y792Y484Y740DDR14YIKBKGMAPK3T17715SNAI225YWHAB26FN1Autophagy22Gliobalstoma cancerDDR112Radio chemotherapyMAPK127Y204COLA1RELA6, 2318MAPK3Y204 2DDR1DDR1Y513Y79220Y7929ICAM17DDR120COL4A12CDH211VIM11F2RL212NFKB1A29FibrosisPPP1R1B31MYH95CDH118InflammationCancer progression and metastasisCYNUCYNUProteinReceptorProteinmRNALigandInhibitionRegulation of gene/protein expressionLeads to through multiple reactionsPTM stateLEGENDGene/ProteinGene/ProteinUpregulationDownregulation


Description

Schematic representation of DDR1-mediated signaling pathway

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Bibliography

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  1. Aguilera KY, Huang H, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA; ''Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma.''; Mol Cancer Ther, 2017 PubMed Europe PMC Scholia
  2. Vella V, Nicolosi ML, Cantafio P, Massimino M, Lappano R, Vigneri P, Ciuni R, Gangemi P, Morrione A, Malaguarnera R, Belfiore A; ''DDR1 regulates thyroid cancer cell differentiation via IGF-2/IR-A autocrine signaling loop.''; Endocr Relat Cancer, 2019 PubMed Europe PMC Scholia
  3. Park HS, Kim KR, Lee HJ, Choi HN, Kim DK, Kim BT, Moon WS; ''Overexpression of discoidin domain receptor 1 increases the migration and invasion of hepatocellular carcinoma cells in association with matrix metalloproteinase.''; Oncol Rep, 2007 PubMed Europe PMC Scholia
  4. Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ, Johnson KR; ''Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1.''; J Cell Biol, 2008 PubMed Europe PMC Scholia
  5. Buraschi S, Morcavallo A, Neill T, Stefanello M, Palladino C, Xu SQ, Belfiore A, Iozzo RV, Morrione A; ''Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer.''; Matrix Biol Plus, 2020 PubMed Europe PMC Scholia
  6. Seo MC, Kim S, Kim SH, Zheng LT, Park EK, Lee WH, Suk K; ''Discoidin domain receptor 1 mediates collagen-induced inflammatory activation of microglia in culture.''; J Neurosci Res, 2008 PubMed Europe PMC Scholia
  7. Romayor I, Badiola I, Olaso E; ''Inhibition of DDR1 reduces invasive features of human A375 melanoma, HT29 colon carcinoma and SK-HEP hepatoma cells.''; Cell Adh Migr, 2020 PubMed Europe PMC Scholia
  8. Matsuyama W, Wang L, Farrar WL, Faure M, Yoshimura T; ''Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: role of p38 mitogen-activated protein kinase and NF-kappa B.''; J Immunol, 2004 PubMed Europe PMC Scholia
  9. Jeitany M, Leroy C, Tosti P, Lafitte M, Le Guet J, Simon V, Bonenfant D, Robert B, Grillet F, Mollevi C, El Messaoudi S, Otandault A, Canterel-Thouennon L, Busson M, Thierry AR, Martineau P, Pannequin J, Roche S, Sirvent A; ''Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer.''; EMBO Mol Med, 2018 PubMed Europe PMC Scholia
  10. Shimada K, Nakamura M, Ishida E, Higuchi T, Yamamoto H, Tsujikawa K, Konishi N; ''Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer.''; Cancer Sci, 2008 PubMed Europe PMC Scholia
  11. Miao L, Zhu S, Wang Y, Li Y, Ding J, Dai J, Cai H, Zhang D, Song Y; ''Discoidin domain receptor 1 is associated with poor prognosisof non-small cell lung cancer and promotes cell invasion via epithelial-to-mesenchymal transition.''; Med Oncol, 2013 PubMed Europe PMC Scholia
  12. Hidalgo-Carcedo C, Hooper S, Chaudhry SI, Williamson P, Harrington K, Leitinger B, Sahai E; ''Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.''; Nat Cell Biol, 2011 PubMed Europe PMC Scholia
  13. Huang H, Svoboda RA, Lazenby AJ, Saowapa J, Chaika N, Ding K, Wheelock MJ, Johnson KR; ''Up-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1.''; J Biol Chem, 2016 PubMed Europe PMC Scholia
  14. Hur H, Ham IH, Lee D, Jin H, Aguilera KY, Oh HJ, Han SU, Kwon JE, Kim YB, Ding K, Brekken RA; ''Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma.''; BMC Cancer, 2017 PubMed Europe PMC Scholia
  15. Ye L, Pu C, Tang J, Wang Y, Wang C, Qiu Z, Xiang T, Zhang Y, Peng W; ''Transmembrane-4 L-six family member-1 (TM4SF1) promotes non-small cell lung cancer proliferation, invasion and chemo-resistance through regulating the DDR1/Akt/ERK-mTOR axis.''; Respir Res, 2019 PubMed Europe PMC Scholia
  16. Yoshida D, Teramoto A; ''The use of 3-D culture in peptide hydrogel for analysis of discoidin domain receptor 1-collagen interaction.''; Cell Adh Migr, 2007 PubMed Europe PMC Scholia
  17. ''''; , PubMed Europe PMC Scholia
  18. Azizi R, Salemi Z, Fallahian F, Aghaei M; ''Inhibition of didscoidin domain receptor 1 reduces epithelial-mesenchymal transition and induce cell-cycle arrest and apoptosis in prostate cancer cell lines.''; J Cell Physiol, 2019 PubMed Europe PMC Scholia
  19. Vella V, Malaguarnera R, Nicolosi ML, Palladino C, Spoleti C, Massimino M, Vigneri P, Purrello M, Ragusa M, Morrione A, Belfiore A; ''Discoidin domain receptor 1 modulates insulin receptor signaling and biological responses in breast cancer cells.''; Oncotarget, 2017 PubMed Europe PMC Scholia
  20. Chiusa M, Hu W, Liao HJ, Su Y, Borza CM, de Caestecker MP, Skrypnyk NI, Fogo AB, Pedchenko V, Li X, Zhang MZ, Hudson BG, Basak T, Vanacore RM, Zent R, Pozzi A; ''The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus.''; J Am Soc Nephrol, 2019 PubMed Europe PMC Scholia
  21. Yoshida D, Teramoto A; ''Enhancement of pituitary adenoma cell invasion and adhesion is mediated by discoidin domain receptor-1.''; J Neurooncol, 2007 PubMed Europe PMC Scholia
  22. Zhao Z, Zhao S, Luo L, Xiang Q, Zhu Z, Wang J, Liu Y, Luo J; ''miR-199b-5p-DDR1-ERK signalling axis suppresses prostate cancer metastasis via inhibiting epithelial-mesenchymal transition.''; Br J Cancer, 2021 PubMed Europe PMC Scholia
  23. Kim SH, Lee S, Suk K, Bark H, Jun CD, Kim DK, Choi CH, Yoshimura T; ''Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A.1 murine macrophages.''; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia
  24. Assent D, Bourgot I, Hennuy B, Geurts P, Noël A, Foidart JM, Maquoi E; ''A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells.''; PLoS One, 2015 PubMed Europe PMC Scholia
  25. Xie X, He H, Zhang N, Wang X, Rui W, Xu D, Zhu Y; ''Overexpression of DDR1 Promotes Migration, Invasion, Though EMT-Related Molecule Expression and COL4A1/DDR1/MMP-2 Signaling Axis.''; Technol Cancer Res Treat, 2020 PubMed Europe PMC Scholia
  26. Vehlow A, Klapproth E, Jin S, Hannen R, Hauswald M, Bartsch JW, Nimsky C, Temme A, Leitinger B, Cordes N; ''Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity.''; Cell Rep, 2019 PubMed Europe PMC Scholia
  27. Malaguarnera R, Nicolosi ML, Sacco A, Morcavallo A, Vella V, Voci C, Spatuzza M, Xu SQ, Iozzo RV, Vigneri R, Morrione A, Belfiore A; ''Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling andbiological responses.''; Oncotarget, 2015 PubMed Europe PMC Scholia
  28. Hou G, Vogel W, Bendeck MP; ''The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair.''; J Clin Invest, 2001 PubMed Europe PMC Scholia
  29. Das S, Ongusaha PP, Yang YS, Park JM, Aaronson SA, Lee SW; ''Discoidin domain receptor 1 receptor tyrosine kinase induces cyclooxygenase-2 and promotes chemoresistance through nuclear factor-kappaB pathway activation.''; Cancer Res, 2006 PubMed Europe PMC Scholia
  30. Koo DH, McFadden C, Huang Y, Abdulhussein R, Friese-Hamim M, Vogel WF; ''Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1.''; FEBS Lett, 2006 PubMed Europe PMC Scholia
  31. Hansen C, Greengard P, Nairn AC, Andersson T, Vogel WF; ''Phosphorylation of DARPP-32 regulates breast cancer cell migration downstream of the receptor tyrosine kinase DDR1.''; Exp Cell Res, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126441view18:44, 28 April 2023EgonwLicense is CCZero
124586view05:24, 13 November 2022EgonwNo protein-protein conversions
124464view09:35, 29 October 2022EgonwRemoved non-integer NCBI Gene identifiers
124351view05:08, 19 October 2022EgonwRemoved whitespace in a pubmed id
124348view04:56, 19 October 2022EgonwFixed the UniProt data source and removed faulty Ensembl identifiers
124347view04:50, 19 October 2022EgonwModified title
124288view05:07, 10 October 2022Rex D A BModifications update
124260view09:01, 6 October 2022Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTBGeneProduct
AKT1GeneProduct
AKT1GeneProductAKT1 (EcoGene)
AKT1GeneProductAKT1 (Entrez Gene)
BCAR1ProteinP56945 (Uniprot-TrEMBL)
BCL2L1GeneProductBCL2L1 (Entrez Gene)
BCRGeneProduct
BECN1GeneProductBECN1 (EcoGene)
BIK GeneProductQ13323 (Uniprot-TrEMBL)
CCL2ProteinP13500 (Uniprot-TrEMBL)
CCL3ProteinP10147 (Uniprot-TrEMBL)
CD40GeneProductP25942 (Uniprot-TrEMBL)
CD9ProteinP21926 (Uniprot-TrEMBL)
CDH1GeneProductP12830 (Uniprot-TrEMBL)
CDH2ProteinP19022 (Uniprot-TrEMBL)
CDK1GeneProductP06493 (Uniprot-TrEMBL)
CDK6GeneProductQ00534 (Uniprot-TrEMBL)
CDKN1AGeneProductP38936 (Uniprot-TrEMBL)
COL1GeneProductCOL1 (EcoGene)
COL4A1ProteinP02462 (Uniprot-TrEMBL)
COL4A1GeneProductP02463 (Uniprot-TrEMBL)
COLA1GeneProductCOLA1 (EMBL)
COLA1ProteinP02452 (Entrez Gene)
COLA1ProteinP02452 (Uniprot-TrEMBL)
CTNNB1GeneProduct
CTNNB1GeneProductCTNNB1 (EcoGene)
CXCL8ProteinP10145 (Uniprot-TrEMBL)
DDR1GeneProduct
DDR1ProteinD6R9C4 (Uniprot-TrEMBL)
F2RL2GeneProduct
FN1ProteinP02751 (Uniprot-TrEMBL)
FOSL1GeneProductP15407 (Uniprot-TrEMBL)
HMGA1ProteinP17096 (Uniprot-TrEMBL)
ICAM1ProteinP05362 (Uniprot-TrEMBL)
IGF-1ProteinP05019 (Uniprot-TrEMBL)
IGF1ProteinP05019 (Uniprot-TrEMBL)
IGF1RProteinP08069 (Uniprot-TrEMBL)
IGF2ProteinP01344 (Uniprot-TrEMBL)
IKBKBGeneProductO14920 (Uniprot-TrEMBL)
IKBKGGeneProductQ9Y6K9 (Uniprot-TrEMBL)
IL1BGeneProductP01584 (Uniprot-TrEMBL)
INSRProteinP06213 (Uniprot-TrEMBL)
JUNGeneProductP05412 (Uniprot-TrEMBL)
MAP2K7ProteinO14733 (Uniprot-TrEMBL)
MAP3K11ProteinQ16584 (Uniprot-TrEMBL)
MAPK1GeneProduct
MAPK14GeneProduct
MAPK14GeneProductMAPK14 (EcoGene)
MAPK1GeneProductMAPK1 (EcoGene)
MAPK1GeneProductMAPK1 (Entrez Gene)
MAPK3GeneProduct
MAPK3GeneProductMAPK3
MAPK3GeneProductMAPK3 (EMBL)
MAPK3GeneProductMAPK3 (EcoGene)
MAPK8GeneProduct
MAPK8ProteinP45983 (Uniprot-TrEMBL)
MAPK9GeneProduct
MKI67ProteinP46013 (Uniprot-TrEMBL)
MMP2ProteinP08253 (Uniprot-TrEMBL)
MMP2ProteinP14780 (Uniprot-TrEMBL)
MMP9GeneProductMMP9 (Entrez Gene)
MMP9GeneProductP14780 (Uniprot-TrEMBL)
MTORGeneProduct
MTORGeneProductMTOR (EcoGene)
MYCGeneProductP01106 (Uniprot-TrEMBL)
MYH2GeneProduct
MYH9GeneProduct
MYH9GeneProductMYH9 (EcoGene)
NCK2ProteinO43639 (Uniprot-TrEMBL)
NFKB1AGeneProductP25963 (Uniprot-TrEMBL)
NFKB1GeneProductP19838 (Uniprot-TrEMBL)
NOS2GeneProductP35228 (Uniprot-TrEMBL)
PARD6AGeneProductPARD6A (EcoGene)
PCA-1GeneProduct
PCLAFGeneProductQ15004 (Uniprot-TrEMBL)
PEAK1GeneProduct
PPP1R1BGeneProductQ9UD71 (Uniprot-TrEMBL)
PTGS2GeneProductP35354 (Uniprot-TrEMBL)
PTK2BGeneProduct
PTK2BGeneProductPTK2B (EMBL)
PTK2BProteinQ14289 (Uniprot-TrEMBL)
PTK2ProteinQ05397 (Uniprot-TrEMBL)
PTPN11GeneProductQ06124 (Entrez Gene)
PYK2GeneProductPYK2 (EMBL)
RAP1GAPProteinP47736 (Uniprot-TrEMBL)
RELAGeneProduct
RELAGeneProductRELA (EcoGene)
SEC61BGeneProduct
SHC1ProteinP29353 (Uniprot-TrEMBL)
SNAI2GeneProductO43623 (Uniprot-TrEMBL)
SP1ProteinP08047 (Uniprot-TrEMBL)
SRC ProteinP12931 (Uniprot-TrEMBL)
TM4SF1GeneProduct
TP53ProteinP04637 (Uniprot-TrEMBL)
VCAM1ProteinP19320 (Uniprot-TrEMBL)
VIM1ProteinP08670 (Uniprot-TrEMBL)
VIMProteinP08670 (Uniprot-TrEMBL)
YWHABGeneProduct
ZEB1GeneProductP37275 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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