Comprehensive IL-17A signaling (Mus musculus)

From WikiPathways

Revision as of 21:22, 30 October 2022 by AlexanderPico (Talk | contribs)
Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Airway epithelial cellsInflammation, apoptosis, and migrationHuman bronchial epithelial (HBE) cellsIL-17A mediated pulmonary SMAD- dependent and non-dependent mechanism during acute lung injury in vivoTransforming growth factor beta signalingAlveolar basal epithelial A549 cellsDissociationProteinChemokine ligandsInterleukinsBleomycin-induced pulmonary fibrotic mice modelPulmonary inflammation and fibrosisMinichromosome maintenance (MCM) proteins invovled in DNA replicationIL-11EgfrUpf1Zmpste24Ccl3Cxcl5Orc2Fn1Ccl5Rbbp4Serpine1TNFSrpk2VCANCCL2TGFB1CXCL1Cdc42Cdc42CXCL8Acta1Pole3Rac1CrebbpParp1PlaurCasp3HSPG2Samhd1CacybpACTA2Cxcl1Cxcl12CSF3COL5A2Ccl4AtrxOrc1IL-6LIFDhx9PlauMUC5ACCOL3A1Npm1NaspPcnaPuraNucks1IL-10CXCL2Sqstm1Acta2Igf1Acta2Map1lc3bBaffFbn1Bcl2IL1BHspa1bSnai1Mki67Mcm7Adh1Hmgb1Smad6Col1a1PdgfbHbb-bh1Sod2Y701Stat1Plch1S2448mTORCXCL5S465S467Smad2S423S425Smad3P53IL17RAPrkacbPMAPK1PMAPK3PRKAA1Anxa6PlauIl1bPtgs2CXCL6Mmp3Y199Y458PI3KCABecn1Stat1S473Akt1IL17ACcn2IL17RARac1MAPK14MtorMylkGng12Uggt1Y705Stat3Il6S536RELAMcm5Casp3PdgfaRab10Serpine1S536RELACpne1NFKB1Map1lc3aNFKBIAC3Arpc2Smad7CXCL1RELAY1068EgfrNFKB1BECN1BCL2S9GSK3BDegrease kinase activity GSK3BInhibit autophagy in pulmonary fibrosisDegradation of BCL-2Human lung epithelial cellsS70BCL2NFKBIAPik3c3CFBActa2Cxcl1Hbb-b2Col1a1Psmc6PlaurRelaMcm4Mcm6Particulate matter (PM2.5)CXCL3Bleomycin induced IL-17A activationMcm2Tgfb1Ppp1r14bBlmhSnai2IL8Experimental silica treatment in miceP53RhoaAutophagyPak3GRK5Il1bIL6C7Mmp14Arpc3Gap43Mcm3S2448mTORIL17APPIK3CAActa2Inflammatory neutrophils in the bronchoalveolar spaceRras2Arpc5Atox1Hyou1FibrosisPon3IL-17A stimulationAngpt1IL-17ACxcl12IL17RAMmp9Cxcl2Hbb-b1Tgfb1S467S465Smad2S423S425Smad3Y1008Y1007Jak2Y1035Y1034Jak1Y705Stat3Acute lung injurySTAT1/3 mediated transcriptionalregulationPMAPK1PMAPK3mTORStat3IL-17AIL17RAY1008Y1007Jak2Y1035Y1034Jak1PP53PAkt1Y185T183MAPK14Bleomycin induced IL-17A activationUnilateral Ureteral Obstruction (UUO) injuryIL-17A stimulationIL-17AIL17RANFKB1PNFKBIAChronic airway diseasesIL-17A stimulationReceptorProteinmRNALigandInhibitionLeads to through multiple reactionsLEGENDIL-17A stimulationBleomycin induced IL-17A activationS423S425Smad3DissociationY705Stat3Y701Stat1Y705Stat3TranslocationNucleusCytoplasmPlasma membraneCYPMNUExtracellularECGene/ProteinGene/ProteinUpregulationDownregulationPhosphorylationDissociationNUCYNUCYNUCYNUCYActivationGram-negative bacterial pneumonia infectionProliferation of asthmatic fibrocytesAsthmaIL-10ACTA2Extracellular matrix deposition and neovascularizationApoptosis and injuryBleomycin induced miceRenal fibrosisSilicosis lung inflammation in miceSnai1Col1a1Snai2Tjp1Cdh1Epithelial-mesenchymal transition (EMT) markersHuman primary small airway epithelial cellsMouse alveolar epithelial (MLE-12) cellsPJak2PJak1Particulate matter (PM2.5) stimulationExperimental silica treatment in micePName: Comprehensive IL-17A signaling pathwayLicense: Yenepoya (Deemed to be University)Organism: Mus musculus


Description

Schematic representation of IL-17A signaling pathway

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Rex DAB, Dagamajalu S, Gouda MM, Suchitha GP, Chanderasekaran J, Raju R, Prasad TSK, Bhandary YP; ''A comprehensive network map of IL-17A signaling pathway.''; J Cell Commun Signal, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126495view21:40, 9 May 2023Khanspersadded missing groups, fixed interactions, converted interactions in legend to graphical lines
126212view09:41, 16 April 2023EgonwLicense is CCZero
124849view21:41, 14 December 2022EweitzModified title
124477view21:23, 30 October 2022AlexanderPicoModified description
124476view21:22, 30 October 2022AlexanderPicomore xrefs
124475view21:15, 30 October 2022AlexanderPicoremoved off-map nodes; added ref
124474view21:13, 30 October 2022AlexanderPicocompleted xrefs; fixed legend to use labels
123976view10:33, 9 September 2022EweitzModified title
123802view18:04, 15 August 2022KhanspersOntology Term : 'interleukin-17 family mediated signaling pathway' added !
123801view18:04, 15 August 2022KhanspersOntology Term : 'signaling pathway' added !
123125view04:40, 5 July 2022EgonwWorked on the data sources
123092view08:08, 29 June 2022Rex D A BAnnotations
123091view07:35, 29 June 2022Rex D A BAlignment
123090view06:32, 28 June 2022Rex D A BNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACTA2GeneProduct59 (Entrez Gene)
Acta1GeneProduct11459 (Entrez Gene)
Acta2GeneProduct11475 (Entrez Gene)
Adh1GeneProduct11522 (Entrez Gene)
Akt1GeneProduct207 (Entrez Gene)
Akt1ProteinP31750 (Uniprot-TrEMBL)
Angpt1GeneProductENSMUSG00000022309 (Ensembl)
Anxa6GeneProduct11749 (Entrez Gene)
Arpc2GeneProduct76709 (Entrez Gene)
Arpc3GeneProduct56378 (Entrez Gene)
Arpc5GeneProduct67771 (Entrez Gene)
Atox1GeneProduct11927 (Entrez Gene)
AtrxProteinQ61687 (Uniprot-TrEMBL)
BCL2ProteinP10415.2 (Uniprot-TrEMBL)
BECN1 ProteinQ14457.2 (Uniprot-TrEMBL)
BaffGeneProduct24099 (Entrez Gene)
Bcl2ProteinP10417 (Uniprot-TrEMBL)
Becn1ProteinO88597 (Uniprot-TrEMBL)
BlmhGeneProduct104184 (Entrez Gene)
C3GeneProduct12266 (Entrez Gene)
C7 GeneProduct109828 (Entrez Gene)
CCL2 ProteinP13500 (Uniprot-TrEMBL)
CFBGeneProduct629 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
COL5A2GeneProduct1290 (Entrez Gene)
CSF3ProteinP09919 (Uniprot-TrEMBL)
CXCL1GeneProduct2919 (Entrez Gene)
CXCL1ProteinP09341 (Uniprot-TrEMBL)
CXCL2GeneProduct2920 (Entrez Gene)
CXCL3GeneProduct2921 (Entrez Gene)
CXCL5GeneProduct20311 (Entrez Gene)
CXCL6GeneProduct6372 (Entrez Gene)
CXCL8ProteinP10145 (Uniprot-TrEMBL)
CacybpProteinQ9CXW3 (Uniprot-TrEMBL)
Casp3GeneProduct12367 (Entrez Gene)
Casp3ProteinP05122 (Uniprot-TrEMBL)
Ccl3GeneProduct20302 (Entrez Gene)
Ccl4GeneProduct20303 (Entrez Gene)
Ccl5GeneProduct20304 (Entrez Gene)
Ccn2GeneProduct14219 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
Cdc42ProteinP60766 (Uniprot-TrEMBL)
Cdh1ProteinP09803 (Uniprot-TrEMBL)
Col1a1GeneProduct12842 (Entrez Gene)
Col1a1ProteinP02452 (Uniprot-TrEMBL)
Cpne1GeneProduct266692 (Entrez Gene)
CrebbpGeneProductP45481 (Uniprot-TrEMBL)
Cxcl1GeneProduct14825 (Entrez Gene)
Cxcl12 ProteinP40224 (Uniprot-TrEMBL)
Cxcl12GeneProduct20315 (Entrez Gene)
Cxcl2GeneProduct20310 (Entrez Gene)
Cxcl5GeneProduct20311 (Entrez Gene)
Dhx9ProteinO70133 (Uniprot-TrEMBL)
EgfrProteinQ01279 (Uniprot-TrEMBL)
Fbn1GeneProduct14118 (Entrez Gene)
Fn1GeneProduct14268 (Entrez Gene)
GRK5GeneProduct2869 (Entrez Gene)
GSK3BProteinP49841 (Uniprot-TrEMBL)
Gap43GeneProduct14432 (Entrez Gene)
Gng12GeneProduct14701 (Entrez Gene)
HSPG2GeneProduct3339 (Entrez Gene)
Hbb-b1GeneProduct15129 (Entrez Gene)
Hbb-b2GeneProduct15130 (Entrez Gene)
Hbb-bh1GeneProduct15132 (Entrez Gene)
Hmgb1GeneProduct15289 (Entrez Gene)
Hspa1bGeneProduct15511 (Entrez Gene)
Hyou1GeneProduct12282 (Entrez Gene)
IL-10ProteinP22301 (Uniprot-TrEMBL)
IL-11ProteinP20809 (Uniprot-TrEMBL)
IL-17AGeneProduct3605 (Entrez Gene)
IL-6ProteinP05231 (Uniprot-TrEMBL)
IL17AGeneProduct3605 (Entrez Gene)
IL17RAGeneProduct23765 (Entrez Gene)
IL1BGeneProductP01584.2 (Uniprot-TrEMBL)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct20309 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Il1bGeneProduct16176 (Entrez Gene)
Il1bGeneProductP10749 (Uniprot-TrEMBL)
Il6GeneProduct16193 (Entrez Gene)
Jak1ProteinP23458 (Uniprot-TrEMBL)
Jak1ProteinP52332 (Uniprot-TrEMBL)
Jak2ProteinO60674 (Uniprot-TrEMBL)
Jak2ProteinQ62120 (Uniprot-TrEMBL)
LIFProteinP15018 (Uniprot-TrEMBL)
MAPK14GeneProduct1432 (Entrez Gene) p38
MAPK14ProteinQ16539 (Uniprot-TrEMBL) p38
MAPK1GeneProduct5594 (Entrez Gene) p38
MAPK1ProteinP28482 (Uniprot-TrEMBL) p38
MAPK3GeneProduct5595 (Entrez Gene)
MAPK3ProteinP27361 (Uniprot-TrEMBL)
MUC5ACGeneProduct4586 (Entrez Gene)
Map1lc3aProteinQ91VR7 (Uniprot-TrEMBL)
Map1lc3bProteinQ9CQV6 (Uniprot-TrEMBL)
Mcm2ProteinP97310 (Uniprot-TrEMBL)
Mcm3ProteinP25206 (Uniprot-TrEMBL)
Mcm4Protein17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6ProteinP97311 (Uniprot-TrEMBL)
Mcm7GeneProductQ61881 (Uniprot-TrEMBL)
Mki67GeneProduct17345 (Entrez Gene)
Mmp14GeneProduct17387 (Entrez Gene)
Mmp3GeneProduct17392 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
MylkGeneProduct107589 (Entrez Gene)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKBIAGeneProduct4792 (Entrez Gene)
NaspProteinQ99MD9 (Uniprot-TrEMBL)
Npm1ProteinQ61937 (Uniprot-TrEMBL)
Nucks1ProteinQ80XU3 (Uniprot-TrEMBL)
Orc1ProteinQ9Z1N2 (Uniprot-TrEMBL)
Orc2ProteinQ60862 (Uniprot-TrEMBL)
P53GeneProduct22059 (Entrez Gene)
P53ProteinP04637 (Uniprot-TrEMBL)
PI3KCAProtein5290 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PRKAA1ProteinQ13131 (Uniprot-TrEMBL)
Pak3GeneProduct18481 (Entrez Gene)
Parp1ProteinP11103 (Uniprot-TrEMBL)
PcnaProteinP17918 (Uniprot-TrEMBL)
PdgfaGeneProduct18590 (Entrez Gene)
PdgfbGeneProduct18591 (Entrez Gene)
Pik3c3ProteinQ6PF93 (Uniprot-TrEMBL)
PlauGeneProduct18792 (Entrez Gene)
PlauProteinP06869 (Uniprot-TrEMBL)
PlaurGeneProduct18793 (Entrez Gene)
PlaurProteinP35456 (Uniprot-TrEMBL)
Plch1GeneProduct269437 (Entrez Gene)
Pole3ProteinQ9JKP7 (Uniprot-TrEMBL)
Pon3GeneProductENSMUSG00000029759 (Ensembl)
Ppp1r14bGeneProduct18938 (Entrez Gene)
PrkacbGeneProduct18749 (Entrez Gene)
Psmc6GeneProduct67089 (Entrez Gene)
Ptgs2GeneProduct19225 (Entrez Gene)
PuraProteinP42669 (Uniprot-TrEMBL)
RELAProteinQ04206 (Uniprot-TrEMBL)
Rab10GeneProduct19325 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Rac1ProteinP63001 (Uniprot-TrEMBL)
Rbbp4ProteinQ60972 (Uniprot-TrEMBL)
RelaGeneProduct19697 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Rras2GeneProduct66922 (Entrez Gene)
Samhd1ProteinQ60710 (Uniprot-TrEMBL)
Serpine1GeneProduct66870 (Entrez Gene)
Serpine1ProteinP05121 (Uniprot-TrEMBL)
Smad2Protein17126 (Entrez Gene)
Smad2ProteinQ62432 (Uniprot-TrEMBL)
Smad3Protein17127 (Uniprot-TrEMBL)
Smad3ProteinQ8BUN5 (Uniprot-TrEMBL)
Smad6ProteinO35182 (Uniprot-TrEMBL)
Smad7 ProteinO35253 (Uniprot-TrEMBL)
Snai1ProteinQ02085 (Uniprot-TrEMBL)
Snai2ProteinP97469 (Uniprot-TrEMBL)
Sod2GeneProduct20656 (Entrez Gene)
Sqstm1ProteinQ64337 (Uniprot-TrEMBL)
Srpk2ProteinO54781 (Uniprot-TrEMBL)
Stat1GeneProduct20846 (Entrez Gene)
Stat1ProteinP42225 (Uniprot-TrEMBL)
Stat3ProteinP42227 (Uniprot-TrEMBL)
TGFB1GeneProduct7040 (Entrez Gene)
TNFProteinP01375 (Uniprot-TrEMBL)
Tgfb1ProteinP04202 (Uniprot-TrEMBL)
Tjp1ProteinP39447 (Uniprot-TrEMBL)
Uggt1GeneProduct320011 (Entrez Gene)
Upf1ProteinQ9EPU0 (Uniprot-TrEMBL)
VCANGeneProduct1462 (Entrez Gene)
Zmpste24ProteinQ80W54 (Uniprot-TrEMBL)
mTORProteinP42345.1 (Uniprot-TrEMBL)
mTORProteinQ9JLN9 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5242"
Personal tools