GDNF signaling (Homo sapiens)
From WikiPathways
Description
This pathway shows molecules involved in ligand-receptor interactions and GDNF (Glial cell line-derived neurotrophic factor) receptor activated downstream molecular events including molecular association, enzyme catalysis, translocation, and gene regulation. Information about post-translational modification sites and residues is also depicted.
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Bibliography
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- Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, Zimonjic DB, Popescu NC, Johnson EM Jr, Milbrandt J; ''TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.''; Neuron, 1997 PubMed Europe PMC Scholia
- Koeberle PD, Bähr M; ''The upregulation of GLAST-1 is an indirect antiapoptotic mechanism of GDNF and neurturin in the adult CNS.''; Cell Death Differ, 2008 PubMed Europe PMC Scholia
- Mwangi S, Anitha M, Fu H, Sitaraman SV, Srinivasan S; ''Glial cell line-derived neurotrophic factor-mediated enteric neuronal survival involves glycogen synthase kinase-3beta phosphorylation and coupling with 14-3-3.''; Neuroscience, 2006 PubMed Europe PMC Scholia
- Cao JP, Wang HJ, Yu JK, Liu HM, Gao DS; ''The involvement of NF-kappaB p65/p52 in the effects of GDNF on DA neurons in early PD rats.''; Brain Res Bull, 2008 PubMed Europe PMC Scholia
- Perrinjaquet M, Vilar M, Ibáñez CF; ''Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
- Iwase T, Jung CG, Bae H, Zhang M, Soliven B; ''Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells.''; J Neurochem, 2005 PubMed Europe PMC Scholia
- Murakami H, Iwashita T, Asai N, Iwata Y, Narumiya S, Takahashi M; ''Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase.''; Oncogene, 1999 PubMed Europe PMC Scholia
- Iwahashi N, Murakami H, Nimura Y, Takahashi M; ''Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways.''; Biochem Biophys Res Commun, 2002 PubMed Europe PMC Scholia
- He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M; ''Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation.''; Stem Cells, 2008 PubMed Europe PMC Scholia
- Jiao L, Zhang Y, Hu C, Wang YG, Huang A, He C; ''Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth.''; Cell Res, 2011 PubMed Europe PMC Scholia
- Ohiwa M, Murakami H, Iwashita T, Asai N, Iwata Y, Imai T, Funahashi H, Takagi H, Takahashi M; ''Characterization of Ret-Shc-Grb2 complex induced by GDNF, MEN 2A, and MEN 2B mutations.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
- Ruan H, Luo H, Wang J, Ji X, Zhang Z, Wu J, Zhang X, Wu X; ''Smoothened-independent activation of hedgehog signaling by rearranged during transfection promotes neuroblastoma cell proliferation and tumor growth.''; Biochim Biophys Acta, 2016 PubMed Europe PMC Scholia
- GarcÃa-MartÃnez JM, Pérez-Navarro E, Gavaldà N, Alberch J; ''Glial cell line-derived neurotrophic factor promotes the arborization of cultured striatal neurons through the p42/p44 mitogen-activated protein kinase pathway.''; J Neurosci Res, 2006 PubMed Europe PMC Scholia
- Mijatovic J, Piltonen M, Alberton P, Männistö PT, Saarma M, Piepponen TP; ''Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals.''; Neurobiol Aging, 2011 PubMed Europe PMC Scholia
- Srinivasan S, Anitha M, Mwangi S, Heuckeroth RO; ''Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival.''; Mol Cell Neurosci, 2005 PubMed Europe PMC Scholia
- Tao L, Ma W, Wu L, Xu M, Yang Y, Zhang W, Sha W, Li H, Xu J, Feng R, Xue D, Zhang J, Dooley S, Seki E, Liu P, Liu C; ''Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling.''; Gut, 2019 PubMed Europe PMC Scholia
- Pandey A, Liu X, Dixon JE, Di Fiore PP, Dixit VM; ''Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
- Tansey MG, Baloh RH, Milbrandt J, Johnson EM Jr; ''GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival.''; Neuron, 2000 PubMed Europe PMC Scholia
- Schalm SS, Ballif BA, Buchanan SM, Phillips GR, Maniatis T; ''Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
- Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G; ''Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF.''; J Neurosci, 2008 PubMed Europe PMC Scholia
- Uesaka T, Nagashimada M, Enomoto H; ''GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors.''; J Neurosci, 2013 PubMed Europe PMC Scholia
- Durbec P, Marcos-Gutierrez CV, Kilkenny C, Grigoriou M, Wartiowaara K, Suvanto P, Smith D, Ponder B, Costantini F, Saarma M; ''GDNF signalling through the Ret receptor tyrosine kinase.''; Nature, 1996 PubMed Europe PMC Scholia
- Crupi MJ, Yoganathan P, Bone LN, Lian E, Fetz A, Antonescu CN, Mulligan LM; ''Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2.''; Traffic, 2015 PubMed Europe PMC Scholia
- Fan TC, Yeo HL, Hsu HM, Yu JC, Ho MY, Lin WD, Chang NC, Yu J, Yu AL; ''Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells.''; Cancer Lett, 2018 PubMed Europe PMC Scholia
- Popsueva A, Poteryaev D, Arighi E, Meng X, Angers-Loustau A, Kaplan D, Saarma M, Sariola H; ''GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase.''; J Cell Biol, 2003 PubMed Europe PMC Scholia
- Ishida M, Ichihara M, Mii S, Jijiwa M, Asai N, Enomoto A, Kato T, Majima A, Ping J, Murakumo Y, Takahashi M; ''Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase.''; Cancer Sci, 2007 PubMed Europe PMC Scholia
- Bonanomi D, Chivatakarn O, Bai G, Abdesselem H, Lettieri K, Marquardt T, Pierchala BA, Pfaff SL; ''Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals.''; Cell, 2012 PubMed Europe PMC Scholia
- Calco GN, Stephens OR, Donahue LM, Tsui CC, Pierchala BA; ''CD2-associated protein (CD2AP) enhances casitas B lineage lymphoma-3/c (Cbl-3/c)-mediated Ret isoform-specific ubiquitination and degradation via its amino-terminal Src homology 3 domains.''; J Biol Chem, 2014 PubMed Europe PMC Scholia
- Trupp M, Arenas E, Fainzilber M, Nilsson AS, Sieber BA, Grigoriou M, Kilkenny C, Salazar-Grueso E, Pachnis V, Arumäe U; ''Functional receptor for GDNF encoded by the c-ret proto-oncogene.''; Nature, 1996 PubMed Europe PMC Scholia
- Alao JP, Michlikova S, Dinér P, Grøtli M, Sunnerhagen P; ''Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.''; BMC Cancer, 2014 PubMed Europe PMC Scholia
- Glerup S, Lume M, Olsen D, Nyengaard JR, Vaegter CB, Gustafsen C, Christensen EI, Kjolby M, Hay-Schmidt A, Bender D, Madsen P, Saarma M, Nykjaer A, Petersen CM; ''SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET.''; Cell Rep, 2013 PubMed Europe PMC Scholia
- Plaza-Menacho I, Morandi A, Robertson D, Pancholi S, Drury S, Dowsett M, Martin LA, Isacke CM; ''Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance.''; Oncogene, 2010 PubMed Europe PMC Scholia
- Cao JP, Yu JK, Li C, Sun Y, Yuan HH, Wang HJ, Gao DS; ''Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor.''; J Comp Neurol, 2008 PubMed Europe PMC Scholia
- Yosef N, Ubogu EE; ''GDNF restores human blood-nerve barrier function via RET tyrosine kinase-mediated cytoskeletal reorganization.''; Microvasc Res, 2012 PubMed Europe PMC Scholia
- Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J; ''Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
- Arighi E, Alberti L, Torriti F, Ghizzoni S, Rizzetti MG, Pelicci G, Pasini B, Bongarzone I, Piutti C, Pierotti MA, Borrello MG; ''Identification of Shc docking site on Ret tyrosine kinase.''; Oncogene, 1997 PubMed Europe PMC Scholia
- Park JI, Powers JF, Tischler AS, Strock CJ, Ball DW, Nelkin BD; ''GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice.''; Exp Cell Res, 2005 PubMed Europe PMC Scholia
- Durick K, Wu RY, Gill GN, Taylor SS; ''Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
- Hauck SM, Kinkl N, Deeg CA, Swiatek-de Lange M, Schöffmann S, Ueffing M; ''GDNF family ligands trigger indirect neuroprotective signaling in retinal glial cells.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
- Pandey A, Duan H, Di Fiore PP, Dixit VM; ''The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
- Kim D, Dressler GR; ''PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.''; Dev Biol, 2007 PubMed Europe PMC Scholia
- Moodley S, Lian EY, Crupi MJF, Hyndman BD, Mulligan LM; ''RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma.''; Lung Cancer, 2020 PubMed Europe PMC Scholia
- Wang HJ, Cao JP, Yu JK, Zhang LC, Jiang ZJ, Gao DS; ''Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB signaling pathway.''; Eur J Pharmacol, 2008 PubMed Europe PMC Scholia
- Nozaki C, Asai N, Murakami H, Iwashita T, Iwata Y, Horibe K, Klein RD, Rosenthal A, Takahashi M; ''Calcium-dependent Ret activation by GDNF and neurturin.''; Oncogene, 1998 PubMed Europe PMC Scholia
- Kurokawa K, Iwashita T, Murakami H, Hayashi H, Kawai K, Takahashi M; ''Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.''; Oncogene, 2001 PubMed Europe PMC Scholia
- Zhang Y, Zhu W, Wang YG, Liu XJ, Jiao L, Liu X, Zhang ZH, Lu CL, He C; ''Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth.''; J Cell Sci, 2006 PubMed Europe PMC Scholia
- Alberti L, Borrello MG, Ghizzoni S, Torriti F, Rizzetti MG, Pierotti MA; ''Grb2 binding to the different isoforms of Ret tyrosine kinase.''; Oncogene, 1998 PubMed Europe PMC Scholia
- Yoong LF, Too HP; ''Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2.''; J Neurosci, 2007 PubMed Europe PMC Scholia
- Trupp M, Raynoschek C, Belluardo N, Ibáñez CF; ''Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase.''; Mol Cell Neurosci, 1998 PubMed Europe PMC Scholia
- Mwangi SM, Nezami BG, Obukwelu B, Anitha M, Marri S, Fu P, Epperson MF, Le NA, Shanmugam M, Sitaraman SV, Tseng YH, Anania FA, Srinivasan S; ''Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity.''; Am J Physiol Gastrointest Liver Physiol, 2014 PubMed Europe PMC Scholia
- Bocciardi R, Mograbi B, Pasini B, Borrello MG, Pierotti MA, Bourget I, Fischer S, Romeo G, Rossi B; ''The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck.''; Oncogene, 1997 PubMed Europe PMC Scholia
- Uchida M, Enomoto A, Fukuda T, Kurokawa K, Maeda K, Kodama Y, Asai N, Hasegawa T, Shimono Y, Jijiwa M, Ichihara M, Murakumo Y, Takahashi M; ''Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.''; J Cell Sci, 2006 PubMed Europe PMC Scholia
- Huang SM, Chen TS, Chiu CM, Chang LK, Liao KF, Tan HM, Yeh WL, Chang GR, Wang MY, Lu DY; ''GDNF increases cell motility in human colon cancer through VEGF-VEGFR1 interaction.''; Endocr Relat Cancer, 2014 PubMed Europe PMC Scholia
- Murakami H, Iwashita T, Asai N, Shimono Y, Iwata Y, Kawai K, Takahashi M; ''Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation.''; Biochem Biophys Res Commun, 1999 PubMed Europe PMC Scholia
- Braydich-Stolle L, Kostereva N, Dym M, Hofmann MC; ''Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation.''; Dev Biol, 2007 PubMed Europe PMC Scholia
- Bunone G, Uggeri M, Mondellini P, Pierotti MA, Bongarzone I; ''RET receptor expression in thyroid follicular epithelial cell-derived tumors.''; Cancer Res, 2000 PubMed Europe PMC Scholia
- Poteryaev D, Titievsky A, Sun YF, Thomas-Crusells J, Lindahl M, Billaud M, Arumäe U, Saarma M; ''GDNF triggers a novel ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1.''; FEBS Lett, 1999 PubMed Europe PMC Scholia
- Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, Kojima T, Tamiya-Koizumi K, Sobue S, Ichihara M, Suzuki M, Banno Y, Nozawa Y, Murate T; ''Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.''; J Cell Biochem, 2011 PubMed Europe PMC Scholia
- Kramer ER, Knott L, Su F, Dessaud E, Krull CE, Helmbacher F, Klein R; ''Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb.''; Neuron, 2006 PubMed Europe PMC Scholia
- Tsui CC, Pierchala BA; ''CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.''; J Neurosci, 2008 PubMed Europe PMC Scholia
- Hong Z, Zhang QY, Liu J, Wang ZQ, Zhang Y, Xiao Q, Lu J, Zhou HY, Chen SD; ''Phosphoproteome study reveals Hsp27 as a novel signaling molecule involved in GDNF-induced neurite outgrowth.''; J Proteome Res, 2009 PubMed Europe PMC Scholia
- Trupp M, Scott R, Whittemore SR, Ibáñez CF; ''Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
- Scholz D, Chernyshova Y, Leist M; ''Control of Aβ release from human neurons by differentiation status and RET signaling.''; Neurobiol Aging, 2013 PubMed Europe PMC Scholia
- Mwangi SM, Peng S, Nezami BG, Thorn N, Farris AB 3rd, Jain S, Laroui H, Merlin D, Anania F, Srinivasan S; ''Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression.''; Am J Physiol Gastrointest Liver Physiol, 2016 PubMed Europe PMC Scholia
- Coulpier M, Anders J, Ibáñez CF; ''Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
- Xiao H, Hirata Y, Isobe K, Kiuchi K; ''Glial cell line-derived neurotrophic factor up-regulates the expression of tyrosine hydroxylase gene in human neuroblastoma cell lines.''; J Neurochem, 2002 PubMed Europe PMC Scholia
- Segouffin-Cariou C, Billaud M; ''Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
- Zhang X, Wei R, Sun Y, Xia Q, Xie W, Song H, Wang W, Zou K; ''AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells.''; Stem Cells, 2019 PubMed Europe PMC Scholia
- You L, Ebner S, Kruse FE; ''Glial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells.''; Invest Ophthalmol Vis Sci, 2001 PubMed Europe PMC Scholia
- Cañibano C, Rodriguez NL, Saez C, Tovar S, Garcia-Lavandeira M, Borrello MG, Vidal A, Costantini F, Japon M, Dieguez C, Alvarez CV; ''The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth.''; EMBO J, 2007 PubMed Europe PMC Scholia
- Yang Y, Han C; ''GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway.''; BMC Cell Biol, 2010 PubMed Europe PMC Scholia
- Camarena V, Kobayashi M, Kim JY, Roehm P, Perez R, Gardner J, Wilson AC, Mohr I, Chao MV; ''Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons.''; Cell Host Microbe, 2010 PubMed Europe PMC Scholia
- Encinas M, Rozen EJ, Dolcet X, Jain S, Comella JX, Milbrandt J, Johnson EM Jr; ''Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons.''; Cell Death Differ, 2008 PubMed Europe PMC Scholia
- EnterrÃa-Morales D, López-López I, López-Barneo J, d'Anglemont de Tassigny X; ''Role of Glial Cell Line-Derived Neurotrophic Factor in the Maintenance of Adult Mesencephalic Catecholaminergic Neurons.''; Mov Disord, 2020 PubMed Europe PMC Scholia
- Nakamura TY, Jeromin A, Smith G, Kurushima H, Koga H, Nakabeppu Y, Wakabayashi S, Nabekura J; ''Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons.''; J Cell Biol, 2006 PubMed Europe PMC Scholia
- Yazlovitskaya EM, Viquez OM, Tu T, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Pozzi A, Zent R; ''The laminin binding α3 and α6 integrins cooperate to promote epithelial cell adhesion and growth.''; Matrix Biol, 2019 PubMed Europe PMC Scholia
- Sun Y, Huang X, Liu M, Cao J, Chen J, Wang H, Niu H, Yu Z, Yu J, Wang T, Yuan H, Xu X, Gao DS; ''A new alternative NF-κB pathway mediated the neuroprotection of GDNF on 6-OHDA-induced DA neurons neurotoxicity.''; Brain Res, 2012 PubMed Europe PMC Scholia
- Yoshida S, Yamamoto N, Wada N, Tomokiyo A, Hasegawa D, Hamano S, Mitarai H, Monnouchi S, Yuda A, Maeda H; ''GDNF From Human Periodontal Ligament Cells Treated With Pro-Inflammatory Cytokines Promotes Neurocytic Differentiation of PC12 Cells.''; J Cell Biochem, 2017 PubMed Europe PMC Scholia
- Lundgren TK, Nakahata K, Fritz N, Rebellato P, Zhang S, Uhlén P; ''RET PLCγ phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration.''; PLoS One, 2012 PubMed Europe PMC Scholia
- Hayashi H, Ichihara M, Iwashita T, Murakami H, Shimono Y, Kawai K, Kurokawa K, Murakumo Y, Imai T, Funahashi H, Nakao A, Takahashi M; ''Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor.''; Oncogene, 2000 PubMed Europe PMC Scholia
- Newburn EN, Duchemin AM, Neff NH, Hadjiconstantinou M; ''GM1 ganglioside enhances Ret signaling in striatum.''; J Neurochem, 2014 PubMed Europe PMC Scholia
- Cacalano G, Fariñas I, Wang LC, Hagler K, Forgie A, Moore M, Armanini M, Phillips H, Ryan AM, Reichardt LF, Hynes M, Davies A, Rosenthal A; ''GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney.''; Neuron, 1998 PubMed Europe PMC Scholia
- Meir M, Burkard N, Ungewiß H, Diefenbacher M, Flemming S, Kannapin F, Germer CT, Schweinlin M, Metzger M, Waschke J, Schlegel N; ''Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease.''; J Clin Invest, 2019 PubMed Europe PMC Scholia
- Zhu S, Zhao C, Wu Y, Yang Q, Shao A, Wang T, Wu J, Yin Y, Li Y, Hou J, Zhang X, Zhou G, Gu X, Wang X, Bustelo XR, Zhou J; ''Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking.''; Nat Neurosci, 2015 PubMed Europe PMC Scholia
- Rizzo C, Califano D, Colucci-D'Amato GL, De Vita G, D'Alessio A, Dathan NA, Fusco A, Monaco C, Santelli G, Vecchio G, Santoro M, de Franciscis V; ''Ligand stimulation of a Ret chimeric receptor carrying the activatingmutation responsible for the multiple endocrine neoplasia type 2B.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
- Veit C, Genze F, Menke A, Hoeffert S, Gress TM, Gierschik P, Giehl K; ''Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells.''; Cancer Res, 2004 PubMed Europe PMC Scholia
- Li XZ, Yan J, Huang SH, Zhao L, Wang J, Chen ZY; ''Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion.''; J Biol Chem, 2012 PubMed Europe PMC Scholia
- Zuo T, Qin JY, Chen J, Shi Z, Liu M, Gao X, Gao D; ''Involvement of N-cadherin in the protective effect of glial cell line-derived neurotrophic factor on dopaminergic neuron damage.''; Int J Mol Med, 2013 PubMed Europe PMC Scholia
- Xiao N, Yu WY, Liu D; ''Glial cell-derived neurotrophic factor promotes dental pulp stem cell migration.''; J Tissue Eng Regen Med, 2018 PubMed Europe PMC Scholia
- Miyamoto R, Jijiwa M, Asai M, Kawai K, Ishida-Takagishi M, Mii S, Asai N, Enomoto A, Murakumo Y, Yoshimura A, Takahashi M; ''Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.''; Dev Biol, 2011 PubMed Europe PMC Scholia
- Morandi A, Martin LA, Gao Q, Pancholi S, Mackay A, Robertson D, Zvelebil M, Dowsett M, Plaza-Menacho I, Isacke CM; ''GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.''; Cancer Res, 2013 PubMed Europe PMC Scholia
- Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, Asai N, Takahashi M, Vandlen R, Henderson CE, Rosenthal A; ''Characterization of a multicomponent receptor for GDNF.''; Nature, 1996 PubMed Europe PMC Scholia
- Lee RH, Wong WL, Chan CH, Chan SY; ''Differential effects of glial cell line-derived neurotrophic factor and neurturin in RET/GFRalpha1-expressing cells.''; J Neurosci Res, 2006 PubMed Europe PMC Scholia
- Jing S, Wen D, Yu Y, Holst PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, Louis JC, Hu S, Altrock BW, Fox GM; ''GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.''; Cell, 1996 PubMed Europe PMC Scholia
- Koelsch A, Feng Y, Fink DJ, Mata M; ''Transgene-mediated GDNF expression enhances synaptic connectivity and GABA transmission to improve functional outcome after spinal cord contusion.''; J Neurochem, 2010 PubMed Europe PMC Scholia
- Sada A, Hasegawa K, Pin PH, Saga Y; ''NANOS2 acts downstream of glial cell line-derived neurotrophic factor signaling to suppress differentiation of spermatogonial stem cells.''; Stem Cells, 2012 PubMed Europe PMC Scholia
- Encinas M, Tansey MG, Tsui-Pierchala BA, Comella JX, Milbrandt J, Johnson EM Jr; ''c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway.''; J Neurosci, 2001 PubMed Europe PMC Scholia
- Zhang H, Bagherie-Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, Kuure S, Jain S, McNeill H; ''FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.''; Dev Cell, 2019 PubMed Europe PMC Scholia
- Yang F, Feng L, Zheng F, Johnson SW, Du J, Shen L, Wu CP, Lu B; ''GDNF acutely modulates excitability and A-type K(+) channels in midbrain dopaminergic neurons.''; Nat Neurosci, 2001 PubMed Europe PMC Scholia
- Asai N, Murakami H, Iwashita T, Takahashi M; ''A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
- Paratcha G, Ledda F, Ibáñez CF; ''The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands.''; Cell, 2003 PubMed Europe PMC Scholia
- Takashima S, Kanatsu-Shinohara M, Tanaka T, Morimoto H, Inoue K, Ogonuki N, Jijiwa M, Takahashi M, Ogura A, Shinohara T; ''Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal.''; Stem Cell Reports, 2015 PubMed Europe PMC Scholia
- Borrello MG, Alberti L, Arighi E, Bongarzone I, Battistini C, Bardelli A, Pasini B, Piutti C, Rizzetti MG, Mondellini P, Radice MT, Pierotti MA; ''The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a dockingsite for phospholipase Cgamma.''; Mol Cell Biol, 1996 PubMed Europe PMC Scholia
- Besset V, Scott RP, Ibáñez CF; ''Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
- Su CM, Lu DY, Hsu CJ, Chen HT, Huang CY, Yang WH, Su YC, Yang SN, Fong YC, Tseng WP, Tang CH; ''Glial cell-derived neurotrophic factor increases migration of human chondrosarcoma cells via ERK and NF-kappaB pathways.''; J Cell Physiol, 2009 PubMed Europe PMC Scholia
- Zhang X, Mernaugh G, Yang DH, Gewin L, Srichai MB, Harris RC, Iturregui JM, Nelson RD, Kohan DE, Abrahamson D, Fässler R, Yurchenco P, Pozzi A, Zent R; ''beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity.''; Development, 2009 PubMed Europe PMC Scholia
- Hayashi Y, Iwashita T, Murakamai H, Kato Y, Kawai K, Kurokawa K, Tohnai I, Ueda M, Takahashi M; ''Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation.''; Biochem Biophys Res Commun, 2001 PubMed Europe PMC Scholia
- Chen M, Ba H, Lu C, Dai J, Sun J; ''Glial Cell Line-Derived Neurotrophic Factor (GDNF) Promotes Angiogenesis through the Demethylation of the Fibromodulin (FMOD) Promoter in Glioblastoma.''; Med Sci Monit, 2018 PubMed Europe PMC Scholia
- Zajzon K, Pröls F, Heermann S; ''Concerted interaction of TGF-β and GDNF mediates neuronal differentiation.''; Neuroreport, 2013 PubMed Europe PMC Scholia
- Wang M, Guo Y, Zhou T, Xue Y, Du G, Wei X, Wang J, Qi L, Zhang H, Li L, Ye L, Guo X, Wu X; ''The Glial Cell-Derived Neurotrophic Factor (GDNF)-responsive Phosphoprotein Landscape Identifies Raptor Phosphorylation Required for Spermatogonial Progenitor Cell Proliferation.''; Mol Cell Proteomics, 2017 PubMed Europe PMC Scholia
- Cao JP, Niu HY, Wang HJ, Huang XG, Gao DS; ''NF-κB p65/p52 plays a role in GDNF up-regulating Bcl-2 and Bcl-w expression in 6-OHDA-induced apoptosis of MN9D cell.''; Int J Neurosci, 2013 PubMed Europe PMC Scholia
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