Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical pathway) (Homo sapiens)
From WikiPathways
Description
Hypothetical pathway for complement-mediated inflammation of the pulmonary alveolus in COVID-19.
AEC‐II=Type II alveolar epithelial cell, EC=endothelial cells and MC=monocytes.
Quality Tags
Ontology Terms
Pathway Ontology : disease pathway
Disease : familial chylomicronemia syndrome congenital generalized lipodystrophy type 4 congenital generalized lipodystrophy type 3 hyperlipoproteinemia type V familial hyperlipidemia lipodystrophy familial partial lipodystrophy type 1 hyperlipoproteinemia type III congenital generalized lipodystrophy type 1 lipid metabolism disorder familial hypercholesterolemia hypolipoproteinemia familial partial lipodystrophy type 2 familial partial lipodystrophy type 6 acquired generalized lipodystrophy congenital generalized lipodystrophy type 2 familial partial lipodystrophy type 3 familial partial lipodystrophy type 4 familial partial lipodystrophy type 5 hyperlipoproteinemia type IV familial combined hyperlipidemia abetalipoproteinemia Norum disease Tangier disease
Bibliography
- Polycarpou A, Howard M, Farrar CA, Greenlaw R, Fanelli G, Wallis R, Klavinskis LS, Sacks S; ''Rationale for targeting complement in COVID-19.''; EMBO Mol Med, 2020 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
ACE2 | GeneProduct | ENSG00000130234 (Ensembl) ![]() | |
C3AR1 | GeneProduct | ENSG00000171860 (Ensembl) ![]() | |
C3 | GeneProduct | ENSG00000125730 (Ensembl) ![]() | |
C5AR1 | GeneProduct | ENSG00000197405 (Ensembl) ![]() | |
C5 | GeneProduct | ENSG00000106804 (Ensembl) ![]() | |
C5b | GeneProduct | ENSG00000106804 (Ensembl) ![]() | |
C6 | GeneProduct | ENSG00000039537 (Ensembl) ![]() | |
C7 | GeneProduct | ENSG00000112936 (Ensembl) ![]() | |
C8 | GeneProduct | 731 (Entrez Gene) ![]() | |
C9 | GeneProduct | ENSG00000113600 (Ensembl) ![]() | |
Coagulaton activation | Pathway | WP558 (WikiPathways) ![]() | |
Collectin-11 | Protein | F8WB29 (Uniprot-TrEMBL) ![]() | |
Complement activation | Pathway | WP545 (WikiPathways) ![]() | |
Ficolin-1 | Protein | O00602 (Uniprot-TrEMBL) ![]() | |
MASP2 | GeneProduct | ENSG00000009724 (Ensembl) ![]() |
Annotated Interactions
No annotated interactions