Hippo-YAP signaling (Homo sapiens)

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1NucleusDegradationHippo-YAP pathway "ON"RASSF1MINK1SAV1CXCL10STK3LATS2MAP4K4TNIKLATS1NF2NDRG1YWHAQMAP4K3TEAD1MST1MAP4K2STK38LMAP4K1TAZYY1AP1PPPPPPPYY1AP1PTAZPPPHippo-YAP pathway "OFF"YY1AP1TAZTEAD2TEAD3TEAD4


Description

This is an overview of the Hippo-Yap signaling pathway. YAP and TAZ are phosphorylated and held in cytoplasm when the Hippo-YAP pathway is at the "ON" status. Unphosphorylated YAP and TAZ accumulate in the nucleus with TEAD when the Hippo-Yap pathway is at the "OFF" status.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Zhou W, Zhao M; ''How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases.''; J Immunol Res, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
142014view13:13, 29 November 2025EweitzRefine state positions
142013view13:13, 29 November 2025EweitzEconomize layout
142012view13:11, 29 November 2025EweitzEconomize layout
127213view19:58, 17 August 2023Khanspersupdated YAP/TAZ and added phosphorylation sites
124854view00:14, 15 December 2022EweitzModified description
124853view23:52, 14 December 2022EweitzModified description
124852view23:51, 14 December 2022EweitzModified title
103300view16:21, 21 February 2019MkutmonOntology Term : 'Hippo signaling pathway' added !
103298view16:20, 21 February 2019MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CXCL10GeneProduct3627 (Entrez Gene) MOB1
LATS1GeneProduct9113 (Entrez Gene) LATS1/2
LATS2GeneProduct26524 (Entrez Gene) LATS1/2
MAP4K1GeneProductENSG00000104814 (Ensembl)
MAP4K2GeneProductENSG00000168067 (Ensembl)
MAP4K3GeneProductENSG00000011566 (Ensembl)
MAP4K4GeneProductENSG00000071054 (Ensembl)
MINK1GeneProductENSG00000141503 (Ensembl)
MST1GeneProduct4485 (Entrez Gene) MST1/2
NDRG1GeneProduct10397 (Entrez Gene) NDR1/2
NF2GeneProduct4771 (Entrez Gene) Nf2
RASSF1GeneProductENSG00000068028 (Ensembl)
SAV1GeneProduct60485 (Entrez Gene) SAV1
STK3GeneProduct6788 (Entrez Gene) MST1/2
STK38LGeneProduct23012 (Entrez Gene) NDR1/2
TAZGeneProduct6901 (Entrez Gene) YAP/TAZ
TEAD1GeneProductENSG00000187079 (Ensembl)
TEAD2GeneProductENSG00000074219 (Ensembl)
TEAD3GeneProductENSG00000007866 (Ensembl)
TEAD4GeneProductENSG00000197905 (Ensembl)
TNIKGeneProductENSG00000154310 (Ensembl)
YWHAQGeneProduct10971 (Entrez Gene) 14-3-3
YY1AP1GeneProduct55249 (Entrez Gene) YAP/TAZ

Annotated Interactions

No annotated interactions

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