Hippo-YAP signaling (Homo sapiens)

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1NucleusDegradationHippo-YAP pathway "ON"TAZTNIKLATS1STK3STK38LCXCL10MAP4K3NF2YY1AP1NDRG1LATS2RASSF1YWHAQTEAD1MAP4K1MAP4K4SAV1MAP4K2MST1MINK1PPPPPPPYY1AP1TAZPPPPHippo-YAP pathway "OFF"YY1AP1TAZTEAD2TEAD3TEAD4


Description

When the Hippo-YAP pathway is in the "ON" state, YAP and TAZ are phosphorylated and held in cytoplasm. When the pathway is in the "OFF" state, unphosphorylated YAP and TAZ accumulate in the nucleus with TEAD.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Zhou W, Zhao M; ''How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases.''; J Immunol Res, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127213view19:58, 17 August 2023Khanspersupdated YAP/TAZ and added phosphorylation sites
124854view00:14, 15 December 2022EweitzModified description
124853view23:52, 14 December 2022EweitzModified description
124852view23:51, 14 December 2022EweitzModified title
103300view16:21, 21 February 2019MkutmonOntology Term : 'Hippo signaling pathway' added !
103298view16:20, 21 February 2019MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CXCL10GeneProduct3627 (Entrez Gene) MOB1
LATS1GeneProduct9113 (Entrez Gene) LATS1/2
LATS2GeneProduct26524 (Entrez Gene) LATS1/2
MAP4K1GeneProductENSG00000104814 (Ensembl)
MAP4K2GeneProductENSG00000168067 (Ensembl)
MAP4K3GeneProductENSG00000011566 (Ensembl)
MAP4K4GeneProductENSG00000071054 (Ensembl)
MINK1GeneProductENSG00000141503 (Ensembl)
MST1GeneProduct4485 (Entrez Gene) MST1/2
NDRG1GeneProduct10397 (Entrez Gene) NDR1/2
NF2GeneProduct4771 (Entrez Gene) Nf2
RASSF1GeneProductENSG00000068028 (Ensembl)
SAV1GeneProduct60485 (Entrez Gene) SAV1
STK3GeneProduct6788 (Entrez Gene) MST1/2
STK38LGeneProduct23012 (Entrez Gene) NDR1/2
TAZGeneProduct6901 (Entrez Gene) YAP/TAZ
TEAD1GeneProductENSG00000187079 (Ensembl)
TEAD2GeneProductENSG00000074219 (Ensembl)
TEAD3GeneProductENSG00000007866 (Ensembl)
TEAD4GeneProductENSG00000197905 (Ensembl)
TNIKGeneProductENSG00000154310 (Ensembl)
YWHAQGeneProduct10971 (Entrez Gene) 14-3-3
YY1AP1GeneProduct55249 (Entrez Gene) YAP/TAZ

Annotated Interactions

No annotated interactions

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