GDNF/RET signaling axis (Mus musculus)

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1RepulsionMetanephric mesenchymeMaintenanceNephrogenic cordNephric ductRetGfra1Spry1Foxc1Sox17Eya1Sox11Pax2Sall1Agtr2Foxc2GdnfGata3Fat4Robo2Gli3rBmp4Ift27Ift25Lim1Slit2β-catGrem1Gdnf


Description

GDNF-RET signalling is at the core of the signalling network in kidney development. These signalling interactions between the metanephric mesenchyme and the nephric duct are crucial to ensure the induction of the ureter from the nephric duct.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kozlov VM, Schedl A; ''Duplex kidney formation: developmental mechanisms and genetic predisposition.''; F1000Res, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
125307view20:28, 31 January 2023LarsgwFix PMID in reference
116419view09:10, 7 May 2021EweitzModified title
109222view07:40, 28 February 2020FehrhartFixed connections
109221view07:37, 28 February 2020FehrhartAdded reference
109220view07:34, 28 February 2020FehrhartUpdated version
109145view13:32, 18 February 2020S. ArnoutsOntology Term : 'CAKUT' added !
109144view13:31, 18 February 2020S. ArnoutsOntology Term : 'regulatory pathway' added !
109143view13:29, 18 February 2020S. ArnoutsModified description
109142view13:28, 18 February 2020S. ArnoutsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Agtr2GeneProductENSMUSG00000068122 (Ensembl)
Bmp4GeneProductENSMUSG00000021835 (Ensembl)
Eya1GeneProductENSMUSG00000025932 (Ensembl)
Fat4GeneProductENSMUSG00000046743 (Ensembl)
Foxc1GeneProductENSMUSG00000050295 (Ensembl)
Foxc2GeneProductENSMUSG00000046714 (Ensembl)
Gata3GeneProductENSMUSG00000015619 (Ensembl)
GdnfGeneProductENSMUSG00000022144 (Ensembl)
Gfra1ProteinP97785 (Uniprot-TrEMBL)
Gli3rProteinQ61602 (Uniprot-TrEMBL)
Grem1GeneProductENSMUSG00000074934 (Ensembl)
Ift25ProteinQ9D6H2 (Uniprot-TrEMBL)
Ift27ProteinQ9D0P8 (Uniprot-TrEMBL)
Lim1GeneProductENSMUSG00000018698 (Ensembl)
Pax2GeneProductENSMUSG00000004231 (Ensembl)
RetProteinP35546 (Uniprot-TrEMBL)
Robo2GeneProductENSMUSG00000052516 (Ensembl)
Sall1GeneProductENSMUSG00000031665 (Ensembl)
Slit2GeneProductENSMUSG00000031558 (Ensembl)
Sox11GeneProductENSMUSG00000063632 (Ensembl)
Sox17GeneProductENSMUSG00000025902 (Ensembl)
Spry1GeneProductENSMUSG00000037211 (Ensembl)
β-catProteinQ02248 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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