Metapathway biotransformation (Rattus norvegicus)

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AcetylationReductionHydrolysisOxidationMethylationMethyltransferasesFlavin monooxygenasesCytochrome P450NucleophilesGlutathione reductaseN-acetyltransferasesElectrophilesGlutathione conjugationAldo-keto reductasesAmino acid acyl transferasesAmino acid conjugationSulfotransferasesGlutathione peroxidasesGlutathione synthetaseGlucuronidationEpoxide hydrolasesGlucuronosyltransferasesSulfationGlutathione transferasesAKR1C2UGT1A10CYP27C1Chst10NP_001099351.1Gstm3CYP4F2ComtAkr1a1Substrate-O-RChst1NP_001101195.1Ndst3_predictedSULT1C4NP_001101226.1Cyp11a1GSTM5Substrate-AcUGT1A9CYP3A5GAL3ST1Cyp26a1SULT2A1GPX1Xenobiotic substrateKcnab1Gstp2Gstm5TpmtUGT2B15GSTA5CYP2J2LOC687052GssNP_001102569.1Gsto2Kcnab2Ephx2MethyltransferaseNP_001102492.1GPX2UGT2A2Mgst2MGC105600Nat9_predictedSult1c1NP_001100289.1GSTZ1Cyp51Glutathione transferaseGSTA2CYP4Z1NAT8Ugt1a6Mgst1CYP2C9Aldo-keto reductaseHs3st4CYP2C19GlucuronosyltransferaseSteNP_001100974.1Cyp7a1Ephx1GSTA4UGT2B28Ugt1a1Fmo1NP_001100901.1NAT2MGC108896Cyp27a1CYP2A7UGT2B11Ugt2a1Cyp26c1_predictedNP_001102065.1Substrate-CH3AKR1C3Chst2_predictedChst14NP_001101969.1CYP11B1Substrate-SHGstk1AKR1C4CYP2D6NP_001101988.1BaatLOC690611Amino acid acyltransferaseSult1b1RGD1562825_predictedCyp1a1Substrate=OCyp7b1Sult1a1GlyatNP_001102193.1CYP3A4NAT6SULT1C2UGT1A7Sult1a1GSTA3Ndst4_predictedLOC683774Hs2st1Fmo5HnmtKcnab3SULT4A1CYP4F8Gstt1Fmo3Akr1d1Akr7a2CYP450Gstt2CYP11B2NP_001100897.1Gsto1GSTA1CYP27B1CYP2A13AKR1B10CYP3A43CYP2A6Cyp1b1GSTM1NAT1Cyp20a1Ugt1a2Substrate-GlGLYATL1CYP4F12CHST12AKR1B1Chst9CYP4X1Cyp4f18HS3ST3A1Substrate-NH2Ugt1a3CYP2B6Substrate-SGUgt1a3N-acetyltransferaseCyp4b1Cyp4f39_predictedChst3GsrCyp1a2Fmo4NP_001099210.1NP_001101680.1LOC685402Cyp21a1Cyp19a1CYP4F11Flavin monooxygenaseUgt2a3_predictedCyp17a1UGT2B4GLYATL2Ndst1NP_001100363.1Hs3st1HS3ST3B1Sult1a1Substrate-SO3HCyp24a1Gstt2CHSTB_RATSubstrate-OHCyp2f2Cyp8b1LOC681900UGT2B7Cyp2w1_predictedNP_001099862.1CYP3A7Fmo2CYP2C8Cyp26b1ST2B1_RATChst7HS6ST3Nat8l_predictedGm766NP_001102534.1Sult1a1Akr7a3Gpx3AKR1C1CYP2C18Ugt1a5Hs3st2Substrate-AaSulfotransferaseCyp2e1MGST3NP_001101936.1UGT2B17Gpx5SULT1C1Cyp2u1CYP4V2NP_001100901.1


Description

Biotransformation is the chemical modification (or modifications) made by an organism on a chemical compound. If this modification ends in mineral compounds like CO2, NH4+, or H2O, the biotransformation is called mineralisation. Biotransformation means chemical alteration of chemicals such as nutrients, amino acids, toxins, and drugs in the body. It is also needed to render non-polar compounds polar so that they are not reabsorbed in renal tubules and are excreted. Biotransformation of xenobiotics can dominate toxicokinetics and the metabolites may reach higher concentrations in organisms than their parent compounds.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP702(r29945) with a 60% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
125510view01:44, 24 February 2023AlexanderPicoModified description
69345view18:52, 8 July 2013MaintBotUpdated to 2013 gpml schema
67457view11:04, 26 June 2013DdiglesOntology Term : 'cellular detoxification pathway' added !
58921view05:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58518view20:07, 14 February 2013MaintBotModified title
41657view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
34055view19:04, 9 December 2009MaintBotAutomatic update of empty xrefs
33192view18:08, 5 November 2009KhanspersModified categories
32303view13:17, 15 August 2009MaintBotFixed text labels
31886view12:42, 14 August 2009MaintBotFixed group labels
31332view20:22, 13 August 2009MaintBotFixed text labels
30952view00:43, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKR1B10GeneProduct296972 (Entrez Gene)
AKR1B1GeneProduct24192 (Entrez Gene)
AKR1C1GeneProduct307092 (Entrez Gene)
AKR1C2GeneProduct
AKR1C3GeneProduct
AKR1C4GeneProduct
Akr1a1GeneProductENSRNOG00000016727 (Ensembl)
Akr1d1GeneProductENSRNOG00000013004 (Ensembl)
Akr7a2GeneProductENSRNOG00000017780 (Ensembl)
Akr7a3GeneProductENSRNOG00000017899 (Ensembl)
Aldo-keto reductaseGeneProduct
Amino acid acyltransferaseGeneProduct
BaatGeneProductENSRNOG00000007395 (Ensembl)
CHST12GeneProduct304322 (Entrez Gene)
CHSTB_RATGeneProductENSRNOG00000008885 (Ensembl)
CYP11B1GeneProduct500892 (Entrez Gene)
CYP11B2GeneProduct24294 (Entrez Gene)
CYP27B1GeneProduct114700 (Entrez Gene)
CYP27C1GeneProduct
CYP2A13GeneProduct
CYP2A6GeneProduct
CYP2A7GeneProduct
CYP2B6GeneProduct
CYP2C18GeneProduct
CYP2C19GeneProduct
CYP2C8GeneProduct
CYP2C9GeneProduct
CYP2D6GeneProduct
CYP2J2GeneProduct
CYP3A4GeneProduct
CYP3A43GeneProduct
CYP3A5GeneProduct
CYP3A7GeneProduct
CYP450GeneProduct
CYP4F11GeneProduct
CYP4F12GeneProduct
CYP4F2GeneProduct
CYP4F8GeneProduct
CYP4V2GeneProduct
CYP4X1GeneProduct246767 (Entrez Gene)
CYP4Z1GeneProduct
Chst10GeneProductENSRNOG00000012815 (Ensembl)
Chst14GeneProduct691394 (Entrez Gene)
Chst1GeneProductENSRNOG00000007989 (Ensembl)
Chst2_predictedGeneProductENSRNOG00000037453 (Ensembl)
Chst3GeneProductENSRNOG00000000572 (Ensembl)
Chst7GeneProductENSRNOG00000004258 (Ensembl)
Chst9GeneProduct291770 (Entrez Gene)
ComtGeneProductENSRNOG00000001889 (Ensembl)
Cyp11a1GeneProductENSRNOG00000008074 (Ensembl)
Cyp17a1GeneProductENSRNOG00000020035 (Ensembl)
Cyp19a1GeneProductENSRNOG00000000196 (Ensembl)
Cyp1a1GeneProductENSRNOG00000019500 (Ensembl)
Cyp1a2GeneProductENSRNOG00000016173 (Ensembl)
Cyp1b1GeneProductENSRNOG00000040287 (Ensembl)
Cyp20a1GeneProductENSRNOG00000017631 (Ensembl)
Cyp21a1GeneProduct24298 (Entrez Gene)
Cyp24a1GeneProductENSRNOG00000013062 (Ensembl)
Cyp26a1GeneProductENSRNOG00000016750 (Ensembl)
Cyp26b1GeneProductENSRNOG00000015076 (Ensembl)
Cyp26c1_predictedGeneProductENSRNOG00000030698 (Ensembl)
Cyp27a1GeneProductENSRNOG00000017188 (Ensembl)
Cyp2e1GeneProductENSRNOG00000012458 (Ensembl)
Cyp2f2GeneProductENSRNOG00000032805 (Ensembl)
Cyp2u1GeneProductENSRNOG00000011053 (Ensembl)
Cyp2w1_predictedGeneProductENSRNOG00000022355 (Ensembl)
Cyp4b1GeneProductENSRNOG00000009741 (Ensembl)
Cyp4f18GeneProductENSRNOG00000015751 (Ensembl)
Cyp4f39_predictedGeneProductENSRNOG00000029478 (Ensembl)
Cyp51GeneProductENSRNOG00000007234 (Ensembl)
Cyp7a1GeneProductENSRNOG00000009488 (Ensembl)
Cyp7b1GeneProductENSRNOG00000009730 (Ensembl)
Cyp8b1GeneProductENSRNOG00000019481 (Ensembl)
Ephx1GeneProductENSRNOG00000003515 (Ensembl)
Ephx2GeneProductENSRNOG00000017286 (Ensembl)
Flavin monooxygenaseGeneProduct
Fmo1GeneProductENSRNOG00000034191 (Ensembl)
Fmo2GeneProductENSRNOG00000003510 (Ensembl)
Fmo3GeneProductENSRNOG00000003620 (Ensembl)
Fmo4GeneProductENSRNOG00000003400 (Ensembl)
Fmo5GeneProductENSRNOG00000018076 (Ensembl)
GAL3ST1GeneProduct
GLYATL1GeneProduct
GLYATL2GeneProduct
GPX1GeneProduct24404 (Entrez Gene)
GPX2GeneProduct29326 (Entrez Gene)
GSTA1GeneProduct
GSTA2GeneProduct24422 (Entrez Gene)
GSTA3GeneProduct24421 (Entrez Gene)
GSTA4GeneProduct300850 (Entrez Gene)
GSTA5GeneProduct
GSTM1GeneProduct24423 (Entrez Gene)
GSTM5GeneProduct64352 (Entrez Gene)
GSTZ1GeneProduct681913 (Entrez Gene)
GlucuronosyltransferaseGeneProduct
Glutathione transferaseGeneProduct
GlyatGeneProductENSRNOG00000012142 (Ensembl)
Gm766GeneProductENSRNOG00000036959 (Ensembl)
Gpx3GeneProductENSRNOG00000021809 (Ensembl)
Gpx5GeneProductENSRNOG00000018596 (Ensembl)
GsrGeneProductENSRNOG00000014915 (Ensembl)
GssGeneProductENSRNOG00000018964 (Ensembl)
Gstk1GeneProductENSRNOG00000016484 (Ensembl)
Gstm3GeneProductENSRNOG00000018937 (Ensembl)
Gstm5GeneProductENSRNOG00000018732 (Ensembl)
Gsto1GeneProductENSRNOG00000028746 (Ensembl)
Gsto2GeneProductENSRNOG00000012801 (Ensembl)
Gstp2GeneProductENSRNOG00000018237 (Ensembl)
Gstt1GeneProductENSRNOG00000001242 (Ensembl)
Gstt2GeneProductENSRNOG00000028188 (Ensembl)
HS3ST3A1GeneProduct363618 (Entrez Gene)
HS3ST3B1GeneProduct303218 (Entrez Gene)
HS6ST3GeneProduct364476 (Entrez Gene)
HnmtGeneProductENSRNOG00000005223 (Ensembl)
Hs2st1GeneProductENSRNOG00000012549 (Ensembl)
Hs3st1GeneProductENSRNOG00000010598 (Ensembl)
Hs3st2GeneProductENSRNOG00000017659 (Ensembl)
Hs3st4GeneProductENSRNOG00000036723 (Ensembl)
Kcnab1GeneProductENSRNOG00000010422 (Ensembl)
Kcnab2GeneProductENSRNOG00000011550 (Ensembl)
Kcnab3GeneProductENSRNOG00000008480 (Ensembl)
LOC681900GeneProductENSRNOG00000014672 (Ensembl)
LOC683774GeneProductENSRNOG00000030880 (Ensembl)
LOC685402GeneProductENSRNOG00000022982 (Ensembl)
LOC687052GeneProductENSRNOG00000020743 (Ensembl)
LOC690611GeneProductENSRNOG00000013604 (Ensembl)
MGC105600GeneProductENSRNOG00000028743 (Ensembl)
MGC108896GeneProductENSRNOG00000019221 (Ensembl)
MGST3GeneProduct289197 (Entrez Gene)
MethyltransferaseGeneProduct
Mgst1GeneProductENSRNOG00000007743 (Ensembl)
Mgst2GeneProductENSRNOG00000013296 (Ensembl)
N-acetyltransferaseGeneProduct
NAT1GeneProduct116631 (Entrez Gene)
NAT2GeneProduct116632 (Entrez Gene)
NAT6GeneProduct
NAT8GeneProduct64570 (Entrez Gene)
NP_001099210.1GeneProductENSRNOG00000027171 (Ensembl)
NP_001099351.1GeneProductENSRNOG00000039017 (Ensembl)
NP_001099862.1GeneProductENSRNOG00000000605 (Ensembl)
NP_001100289.1GeneProductENSRNOG00000005930 (Ensembl)
NP_001100363.1GeneProductENSRNOG00000010519 (Ensembl)
NP_001100897.1GeneProductENSRNOG00000016953 (Ensembl)
NP_001100901.1GeneProductENSRNOG00000021521 (Ensembl)
NP_001100974.1GeneProductENSRNOG00000022919 (Ensembl)
NP_001101195.1GeneProductENSRNOG00000011669 (Ensembl)
NP_001101226.1GeneProductENSRNOG00000008663 (Ensembl)
NP_001101680.1GeneProductENSRNOG00000014516 (Ensembl)
NP_001101936.1GeneProductENSRNOG00000038622 (Ensembl)
NP_001101969.1GeneProductENSRNOG00000011367 (Ensembl)
NP_001101988.1GeneProductENSRNOG00000021179 (Ensembl)
NP_001102065.1GeneProductENSRNOG00000010523 (Ensembl)
NP_001102193.1GeneProductENSRNOG00000007147 (Ensembl)
NP_001102492.1GeneProductENSRNOG00000011250 (Ensembl)
NP_001102534.1GeneProductENSRNOG00000001375 (Ensembl)
NP_001102569.1GeneProductENSRNOG00000014192 (Ensembl)
Nat8l_predictedGeneProductENSRNOG00000015466 (Ensembl)
Nat9_predictedGeneProductENSRNOG00000003264 (Ensembl)
Ndst1GeneProductENSRNOG00000019014 (Ensembl)
Ndst3_predictedGeneProductENSRNOG00000015781 (Ensembl)
Ndst4_predictedGeneProductENSRNOG00000009577 (Ensembl)
RGD1562825_predictedGeneProductENSRNOG00000025930 (Ensembl)
ST2B1_RATGeneProductENSRNOG00000021046 (Ensembl)
SULT1C1GeneProduct
SULT1C2GeneProduct171072 (Entrez Gene)
SULT1C4GeneProduct
SULT2A1GeneProduct24912 (Entrez Gene)
SULT4A1GeneProduct58953 (Entrez Gene)
SteGeneProductENSRNOG00000001957 (Ensembl)
Substrate-AaMetabolite
Substrate-AcMetabolite
Substrate-CH3Metabolite
Substrate-GlMetabolite
Substrate-NH2Metabolite
Substrate-O-RMetabolite
Substrate-OHMetabolite
Substrate-SGMetabolite
Substrate-SHMetabolite
Substrate-SO3HMetabolite
Substrate=OMetabolite
SulfotransferaseGeneProduct
Sult1a1GeneProductENSRNOG00000019342 (Ensembl)
Sult1b1GeneProductENSRNOG00000001967 (Ensembl)
Sult1c1GeneProductENSRNOG00000011269 (Ensembl)
TpmtGeneProductENSRNOG00000016468 (Ensembl)
UGT1A10GeneProduct
UGT1A7GeneProduct
UGT1A9GeneProduct396552 (Entrez Gene)
UGT2A2GeneProduct
UGT2B11GeneProduct
UGT2B15GeneProduct
UGT2B17GeneProduct286954 (Entrez Gene)
UGT2B28GeneProduct
UGT2B4GeneProduct
UGT2B7GeneProduct
Ugt1a1GeneProduct24861 (Entrez Gene)
Ugt1a2GeneProduct396527 (Entrez Gene)
Ugt1a3GeneProduct396551 (Entrez Gene)
Ugt1a3GeneProductENSRNOG00000018740 (Ensembl)
Ugt1a5GeneProduct574523 (Entrez Gene)
Ugt1a6GeneProduct113992 (Entrez Gene)
Ugt2a1GeneProductENSRNOG00000001973 (Ensembl)
Ugt2a3_predictedGeneProductENSRNOG00000001975 (Ensembl)
Xenobiotic substrateMetabolite

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1286"
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