IL-9 signaling pathway (Mus musculus)

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Proteins in a complex interactionPlasma membraneCytoplasmDeubiquitinationPMInhibitionControlTranslocationUbiquitinationGolgi apparatusReaction through unknown mechanisms/moleculesDRecruitmentEndosomeLigandCY(Protein-protein interaction)Proteins in a complex interactionAcetylationReceptorProteolytic cleavageDephosphorylationDDesumoylationMTDemethylationMolecule in the pathwayExtracellularAccession Number: NetPath 20DeacetylationPhosphorylationAutophosphorylationERMitochondrionGONUGene SymbolPalmitoylationCY->NUActivationDECENMethylationGlycosylationNucleusEndoplasmic reticulumDSumoylationMolecular associationShc1Stat1Il9rStat3Tyk2VcpIl2rgStat5aMap2k2Socs3Grb2Irs1Jak3Pik3r1Mapk1Irs2Kat5Stat5bMapk3Il9Map2k1Stat3Ptpn11Akt1Jak1


Description

IL-9 is a multifunctional cytokine, belonging to a family of cytokines. IL-9 was initially reported as a T cell growth factor in mice. It is now known to target multiple cell types. It plays an important role in the expansion and recruitment of mast cells in response to intestinal nematode infection or during autoimmune encephalomyelitis. It is also known to act on various cell types known to be involved in asthma including T cells, B cells, mast cells, eosinophils, neutrophils, and epithelial cells. IL-9 can promote the expression of TGF-beta in lipopolysaccharide-induced monocytes and macrophages. IL-9 is also known to play important roles in conditions including airway inflammation, EAE and parasitic infections. Mitogen-activated protein kinase pathway is activated transiently by IL-9, which in turn leads to the growth stimulation of hematopoietic cell lines. IL-9 signals through the heterodimeric receptor composed of a specific chain (IL-9R) and a gamma chain (IL2RG), which is shared between IL-2, IL-4, IL-7, IL15 and IL-21. The IL-9R and IL-2RG associates with JAK1 and JAK3 respectively. Receptor engagement results in JAK1- JAK3 cross phosphorylation and activation of the JAK proteins which leads to the activation of Signal transducer and activator of transcription (STAT-1, STAT-3 and STAT-5) and Insulin receptor substrate 1 and 2 (IRS1 and IRS2)/PI3K cascades. IL-9 stimulation also results in the activation of MEK/ERK signaling cascade.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP22(r20723) with a 100% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
125619view19:29, 5 March 2023AlexanderPicoadded description
117067view14:26, 16 May 2021EweitzModified title
97840view07:50, 10 June 2018EgonwUndo revision 97776 by [[Special:Contributions/AMTan|AMTan]] ([[User talk:AMTan|Talk]])
97776view13:42, 7 June 2018AMTanModified description
69132view18:15, 8 July 2013MaintBotUpdated to 2013 gpml schema
67389view10:46, 26 June 2013Christine ChichesterOntology Term : 'interleukin-9 signaling pathway' added !
43998view18:28, 22 August 2011Khansperscleaned up comments
43997view18:18, 22 August 2011KhanspersChanged comment
43996view18:16, 22 August 2011KhanspersModified description
43995view18:16, 22 August 2011KhanspersModified description
41318view00:24, 2 March 2011MaintBotRemoved redundant pathway information and comments
32482view12:44, 17 August 2009MaintBotFixed text labels
31180view19:27, 13 August 2009MaintBotFixed text labels
30818view23:57, 29 July 2009MaintBotConverted from Homo sapiens
20693view11:29, 14 November 2008MaintBot[[Pathway:Mus musculus:IL-9 NetPath 20]] moved to [[Pathway:WP10]]: Moved to stable identifier
8202view13:46, 7 January 2008MaintBot[[Pathway:Mouse:IL-9 NetPath 20]] moved to [[Pathway:Mus musculus:IL-9 NetPath 20]]: Renaming species
7721view16:13, 18 December 2007MaintBotfixed category names
7260view12:41, 4 November 2007MaintBotAdded categories to GPML
6465view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:IL-9_NetPath_20]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct11651 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Il2rgGeneProduct16186 (Entrez Gene)
Il9GeneProduct16198 (Entrez Gene)
Il9rGeneProduct16199 (Entrez Gene)
Irs1GeneProduct16367 (Entrez Gene)
Irs2GeneProduct384783 (Entrez Gene)
Jak1GeneProduct16451 (Entrez Gene)
Jak3GeneProduct16453 (Entrez Gene)
Kat5GeneProduct81601 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
Shc1GeneProduct20416 (Entrez Gene)
Socs3GeneProduct12702 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Stat5aGeneProduct20850 (Entrez Gene)
Stat5bGeneProduct20851 (Entrez Gene)
Tyk2GeneProduct54721 (Entrez Gene)
VcpGeneProduct269523 (Entrez Gene)

Annotated Interactions

No annotated interactions
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