Cardiomyocyte signaling converging on titin (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none M-bandTTNTKTTNPEVKPTTNN2APTTNN2BPTTNTitin domainsZ-discTTNTTNTTNHypertrophic signallingNPR1GUCD1calcium(2+)Protein Quality ControlPRKAR1APRKACBPRKACAPRKACGGTP(4 - )ANKRD23ANKRD1MYPNANKRD2FHL1FHL2NOSRFTRIM55TRIM63GUCY1B1TCAPMAPK1RASMAP2K1MAP2K2RAF1PRKCACSRP3CAMK2APRKG23',5'-cyclic GMPNBR1NUP623',5'-cyclic AMPCapn1CRYABATPFHL2MDM2GPCRPLCZ1ADRB2ADRB1adenylyl cyclaseName: Cardiomyocyte signaling pathways converging on TitinOrganism: Homo sapiens


Description

Cardiac titin phosphorylation and its involvement in Protein Quality Control pathways as well as Hypertrophic Signalling.

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Quality Tags

Image:MissingXref.pngAnnotate nodes
Image:Curated.pngReview changes for Approved

Ontology Terms

Pathway Ontology : classic metabolic pathway
Cell Type : cardiac muscle cell
 

Bibliography

  1. Linke WA, Hamdani N; ''Gigantic business: titin properties and function through thick and thin.''; Circ Res, 2014 PubMed Europe PMC Scholia
  2. Linke, WA, Krüger, Martina; ''The giant protein titin: a regulatory node that integrates myocyte signaling pathways.''; J Biol Chem, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129750
Approved
view01:58, 22 May 2024EweitzModified title
128794view01:41, 22 February 2024EweitzModified description
128793view01:41, 22 February 2024EweitzOntology Term : 'cardiac muscle cell' added !
128792view01:40, 22 February 2024EweitzModified title
128787view00:22, 22 February 2024EweitzStandardize nomenclature, case
125919view05:55, 20 March 2023EgonwUpdated two UniProt data sources
125904view14:13, 17 March 2023JmillanacostaFixed citation (encoded characters)
125901view11:17, 17 March 2023SnnrrdcOntology Term : 'signaling pathway' added !
125900view11:17, 17 March 2023SnnrrdcOntology Term : 'Ras superfamily mediated signaling pathway' added !
125899view11:13, 17 March 2023Isa LeendersModified description
125898view11:09, 17 March 2023Isa LeendersModified title
125897view11:05, 17 March 2023Bep3.14eIncorrect TTN node was removed.
125896view11:04, 17 March 2023Bep3.14eTitle was changed to a more descriptive one. Gene names and Node labels were corrected. Layout was changed for visual clarification. Arrow/line types and styles were updated.
125866view14:16, 14 March 2023Bep3.14eUnused data nodes were removed and a pathway title was added.
125865view14:13, 14 March 2023Bep3.14eNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
3',5'-cyclic AMPMetaboliteCHEBI:17489 (ChEBI)
3',5'-cyclic GMPMetaboliteCHEBI:16356 (ChEBI)
ADRB1GeneProductP08588 (Uniprot-TrEMBL)
ADRB2GeneProductP07550 (Uniprot-TrEMBL)
ANKRD1GeneProductENSG00000148677 (Ensembl)
ANKRD23GeneProductENSG00000163126 (Ensembl)
ANKRD2GeneProductENSG00000165887 (Ensembl)
ATPMetaboliteCHEBI:30616 (ChEBI)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CRYABGeneProductP02511 (Uniprot-TrEMBL)
CSRP3GeneProductENSG00000129170 (Ensembl)
Capn1GeneProductQ3TB79 (Uniprot-SwissProt)
FHL1GeneProductQ13642 (Uniprot-TrEMBL)
FHL2GeneProductQ14192 (Uniprot-TrEMBL)
GPCRGeneProductQ8TDU1 (Uniprot-TrEMBL)
GTP(4 - )MetaboliteCHEBI:37565 (ChEBI)
GUCD1GeneProductENSG00000138867 (Ensembl)
GUCY1B1GeneProductENSG00000061918 (Ensembl)
Hypertrophic signallingPathway
MAP2K1GeneProductQ02750 (Uniprot-TrEMBL)
MAP2K2GeneProductP36507 (Uniprot-TrEMBL)
MAPK1GeneProductENSG00000100030 (Ensembl)
MDM2GeneProductQ00987 (Uniprot-TrEMBL)
MYPNGeneProductENSG00000138347 (Ensembl)
NBR1GeneProductQ14596 (Uniprot-TrEMBL)
NOMetaboliteCHEBI:16480 (ChEBI)
NPR1GeneProductP16066 (Uniprot-SwissProt)
NUP62GeneProductP37198 (Uniprot-TrEMBL)
PLCZ1GeneProductENSG00000139151 (Ensembl)
PRKACAGeneProductP17612 (Uniprot-TrEMBL)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKG2GeneProductQ13237 (Uniprot-TrEMBL)
Protein Quality ControlPathway
RAF1GeneProductP04049 (Uniprot-TrEMBL)
RASGeneProductP01114 (Uniprot-TrEMBL)
SRFGeneProductP11831 (Uniprot-TrEMBL)
TCAPGeneProductENSG00000173991 (Ensembl)
TRIM55GeneProductQ9BYV6 (Uniprot-TrEMBL)
TRIM63GeneProductQ969Q1 (Uniprot-TrEMBL)
TTNGeneProductENSG00000155657 (Ensembl)
adenylyl cyclaseGeneProductQ59FG4 (Uniprot-TrEMBL)
calcium(2+)MetaboliteCHEBI:29108 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5344"
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