Iron-sulfur cluster biogenesis (Homo sapiens)
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Description
Sialic acids are monosaccharides derived from neuraminic acid, with the two most commonly occurring mammalian sialic acids being N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). Sialic acids are commonly part of glycoproteins, glycolipids or gangliosides, where they decorate the end of sugar chains at the surface of cells or soluble proteins. Sialylated conjugates play important roles in many processes, including cell recognition and signaling, neuronal development, cancer metastasis and bacterial or viral infection
This pathway describes the biosynthesis of Neu5Ac, and was modeled based on figure 1 from Zhou et al.
Quality Tags
Ontology Terms
Saving...Bibliography
- Friemel M, Marelja Z, Li K, Leimkühler S; ''The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1.''; Biochemistry, 2017 PubMed Europe PMC Scholia
- Rouault TA, Tong WH; ''Iron-sulfur cluster biogenesis and human disease.''; Trends Genet, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| CMAS | GeneProduct | ENSG00000111726 (Ensembl)  | |
| CMP-Neu5Ac | Metabolite | CHEBI:16556 (ChEBI) | |
| GNE | GeneProduct | ENSG00000159921 (Ensembl) | |
| Glucose | Metabolite | CHEBI:17234 (ChEBI) | |
| ManNAc-6-P | Metabolite | CHEBI:28273 (ChEBI) | |
| ManNAc | Metabolite | CHEBI:63153 (ChEBI) | |
| NANP | GeneProduct | ENSG00000170191 (Ensembl) | |
| NANS | GeneProduct | ENSG00000095380 (Ensembl) | |
| Neu5Ac | Metabolite | CHEBI:17012 (ChEBI) | |
| NeuAc-9-P | Metabolite | HMDB04381 (HMDB) | |
| SLC35A1 | GeneProduct | ENSG00000164414 (Ensembl) | |
| Sialyltransferase | GeneProduct | ||
| UDP-GlcNAc | Metabolite | CHEBI:16264 (ChEBI) |
Annotated Interactions
No annotated interactions
