Iron-sulfur cluster biogenesis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Mitochondrial Fe-S proteinse-L-cysteineFXNNFS1LYRM4ISCUSFeFe[4Fe-4S] clusterISCUFDX1FDXRABCB7HSPA9HSCBGLRX5NUBP2NUBP1[4Fe-4S] clusterNARFCIAO1CIAO2BFXNNFU1NFS1ISCUFeFeCytosolicFe-S proteinsName: Iron-sulfur cluster biogenesisOrganism: Homo sapiens


Description

This pathway describes the biogenesis of iron-sulphur clusters. Iron-sulphur clusters bind to proteins and are essential components of respiratory electron transfer complexes as well as many other biological processes. This pathway was modeled based on Fig 2a from Rouault and Tong.

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

  1. Rouault TA, Tong WH; ''Iron-sulfur cluster biogenesis and human disease.''; Trends Genet, 2008 PubMed Europe PMC Scholia
  2. Friemel M, Marelja Z, Li K, Leimkühler S; ''The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1.''; Biochemistry, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137686
Approved
view05:13, 7 March 2025EgonwModified description
136735view03:16, 20 February 2025EweitzClear board dimension cache
136734view03:16, 20 February 2025EweitzEconomize layout
125997view18:20, 24 March 2023KhanspersOntology Term : 'regulatory pathway' added !
125989view18:12, 23 March 2023KhanspersModified description
125986view18:06, 23 March 2023Khansperslatest - updated xrefs
125985view18:04, 23 March 2023KhanspersReverted to version '17:47, 23 March 2023' by Khanspers
125984view18:03, 23 March 2023Khansperslatest - updated xrefs
125983view17:47, 23 March 2023KhanspersModified description
125982view17:31, 23 March 2023KhanspersModified description
125981view17:31, 23 March 2023Khanspersupdate with latest
120555view00:20, 15 December 2021KhanspersOntology Term : 'iron-sulfur cluster protein biogenesis pathway' added !
120554view00:19, 15 December 2021KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ABCB7GeneProductENSG00000131269 (Ensembl)
CIAO1GeneProductENSG00000144021 (Ensembl)
CIAO2BGeneProduct51647 (Entrez Gene)
FDX1GeneProduct2230 (Entrez Gene)
FDXRGeneProduct2232 (Entrez Gene)
FXNGeneProduct2395 (Entrez Gene)
FeMetaboliteCHEBI:18248 (ChEBI)
GLRX5GeneProduct51218 (Entrez Gene)
HSCBGeneProduct150274 (Entrez Gene)
HSPA9GeneProduct3313 (Entrez Gene)
ISCUGeneProduct23479 (Entrez Gene)
L-cysteineMetaboliteCHEBI:17561 (ChEBI)
LYRM4GeneProduct57128 (Entrez Gene)
NARFGeneProduct26502 (Entrez Gene)
NFS1GeneProduct9054 (Entrez Gene)
NFU1GeneProduct27247 (Entrez Gene)
NUBP1GeneProductENSG00000103274 (Ensembl)
NUBP2GeneProduct10101 (Entrez Gene)
SMetaboliteCHEBI:26833 (ChEBI)
[4Fe-4S] clusterMetaboliteCHEBI:49883 (ChEBI)
e-MetaboliteCHEBI:10545 (ChEBI)

Annotated Interactions

No annotated interactions

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