IL26 signaling (Homo sapiens)

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NUHeterodimeric receptor complexIL26 interacts with EPH Receptor A3and inhibits EGFR-TKI-induced endoplasmic reticulum (ER) stressInhibitionAsthmaMacrophage differentiationin RAW264.7 cells LEGENDIL26 exacerbates liver fibrosis by promoting the proliferation and activation of hepatic stellate cellsIL10R2IL20R1JAK29PNos210Cd8010Tnf10TGFB1SMAD213CASP313cleaved CASP31313BAX13IL6IL1013TNF1313MMP913ACTA2Supresses apoptosis and promotes liver fibrosis of hepatic stellate cells (HSCs) 13MAPK3Y2043-5, 8, 11T202MAPK1T185Y1874, 5, 8, 11MAPK8T1832, 4, 5, 8, 11Y185MAPK144, 8, 11Y182T180STAT1S727Y7054, 5, 7-9, 11Y701COX2MMP11111IL6Induces proinflammatory effects in human articularchondrocytes (HACs), keratinocytes and colonic subepithelial myofibroblasts/adenocarcinoma 4, 11NFKBIAS328STAT33-5, 7-9Y705S727TNFSF11 TRAP8OCSTAMP88ATP6V0D2CTSK88 NFATC1DCSTAMP8Involved in osteoclastogenesis in RA (rheumatoid arthritis) fibroblast-like synoviocytes (FLSs) 8IL26EPHA3 22AKT12, 4S73DDIT3 2IL1B12IL6TNF12IL17A1212RORC12IL-26 overexpressioninduces proinflammation in asthmatic patients RELACXCL8S536104, 5, 7MAPK94, 5T183Y185TNF5Ccl3Mpo6Mmp966Mmp26Tnf6Ccl20Cxcl26Csf6Facilitates innate immune response in bronchoalveolar space of mice6JAK19PTYK2P9IL8IL1B99CCL209IL339DEFB49Il4Il1399Il33Il17a9Ccl2099Involved in human epidermal keratinocytes Atopic dermatitisIL8 SOCS355CXCL8IL1B1TNF1STAT111STAT31CSF21MPOInvolved in antibacterial host defense1IL10ICAM177LigandProteinmRNARegulation of protein/gene expressionLeads to multple reactionsProteinPPost translational modificationGene/ProteinUpregulationDownregulationInduces antiapoptosis and tumor growth in murine and human TNBC cellsPIK3CA4PRELAIl6S5364, 1010Il1010IL26Gene/ProteinLeads to EPHA3 mediated signalingReceptor 1Receptor 2Liver fibrosisRheumatoid arthritisJUNS734, 11CYNUCYTranslocationCytoplasmCytoplasmJUNS734, 11NUCY


Description

A comprehensive network map of IL-26 signaling pathway

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Bibliography

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  1. Chen YT, Wang CC, Cheng CP, Liu FC, Lee CH, Lee HS, Peng YJ; ''Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway.''; Cells, 2021 PubMed Europe PMC Scholia
  2. Dambacher J, Beigel F, Zitzmann K, De Toni EN, Goke B, Diepolder HM, Auernhammer CJ, Brand S; ''The role of the novel Th17 cytokine IL-26 in intestinal inflammation.''; Gut, 2009 PubMed Europe PMC Scholia
  3. Fujii M, Nishida A, Imaeda H, Ohno M, Nishino K, Sakai S, Inatomi O, Bamba S, Kawahara M, Shimizu T, Andoh A; ''Expression of Interleukin-26 is upregulated in inflammatory bowel disease.''; World J Gastroenterol, 2017 PubMed Europe PMC Scholia
  4. Bao A, Che KF, Bozinovski S, Ji J, Gregory JA, Georen SK, Adner M, Cardell LO, Linden A; ''Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo.''; PLoS One, 2017 PubMed Europe PMC Scholia
  5. Zhang X, Xie X, Wang Y, Li W, Lin Z; ''Interleukin-26 promotes the proliferation and activation of hepatic stellate cells to exacerbate liver fibrosis by the TGF-B1/Smad2 signaling pathway.''; Int J Clin Exp Pathol, 2019 PubMed Europe PMC Scholia
  6. Louhaichi S, Mlika M, Hamdi B, Hamzaoui K, Hamzaoui A; ''Sputum IL-26 Is Overexpressed in Severe Asthma and Induces Proinflammatory Cytokine Production and Th17 Cell Generation: A Case-Control Study of Women.''; J Asthma Allergy, 2020 PubMed Europe PMC Scholia
  7. Mayer P, Linnebacher A, Glennemeier-Marke H, Marnet N, Bergmann F, Hackert T, Klauss M, Poth T, Gaida MM; ''The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  8. Lee KA, Kim KW, Kim BM, Won JY, Min HK, Lee DW, Kim HR, Lee SH; ''Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis.''; Arthritis Res Ther, 2019 PubMed Europe PMC Scholia
  9. Lin YH, Wang YH, Peng YJ, Liu FC, Lin GJ, Huang SH, Sytwu HK, Cheng CP; ''Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-kB Pathway.''; Cells, 2020 PubMed Europe PMC Scholia
  10. Che KF, Tengvall S, Levanen B, Silverpil E, Smith ME, Awad M, Vikstrom M, Palmberg L, Qvarfordt I, Skold M, Linden A; ''Interleukin-26 in antibacterial host defense of human lungs. Effects on neutrophil mobilization.''; Am J Respir Crit Care Med, 2014 PubMed Europe PMC Scholia
  11. Hor S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld JC, de Waal Malefyt R, Fickenscher H; ''The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  12. Itoh T, Hatano R, Horimoto Y, Yamada T, Song D, Otsuka H, Shirakawa Y, Mastuoka S, Iwao N, Aune TM, Dang NH, Kaneko Y, Okumura K, Morimoto C, Ohnuma K; ''IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells.''; Cell Death Dis, 2021 PubMed Europe PMC Scholia
  13. Kamijo H, Miyagaki T, Hayashi Y, Akatsuka T, Watanabe-Otobe S, Oka T, Shishido-Takahashi N, Suga H, Sugaya M, Sato S; ''Increased IL-26 Expression Promotes T Helper Type 17- and T Helper Type 2-Associated Cytokine Production by Keratinocytes in Atopic Dermatitis.''; J Invest Dermatol, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129744view01:55, 22 May 2024EweitzModified title
126468view05:51, 2 May 2023EgonwNot mim-conversions
126466view04:46, 2 May 2023EgonwBinding instead?
126456view20:24, 30 April 2023AlexanderPicoremoved more data-coded color
126455view20:21, 30 April 2023AlexanderPicoremoved data-coded color; replaced datanodes in legend
126454view20:05, 30 April 2023AlexanderPicofixed citations
126072view22:35, 31 March 2023KhanspersOntology Term : 'interleukin-6 signaling pathway' added !
126071view22:35, 31 March 2023KhanspersOntology Term : 'signaling pathway' added !
126019view07:49, 27 March 2023Rex D A B
126018view07:48, 27 March 2023Rex D A B
126017view07:43, 27 March 2023Rex D A B
126016view07:25, 27 March 2023Rex D A B
126015view05:31, 27 March 2023Rex D A B
126014view05:25, 27 March 2023Rex D A B
126013view05:19, 27 March 2023Rex D A B
126010view10:29, 26 March 2023EgonwUpdated the UniProt data sources
126009view13:48, 25 March 2023Rex D A B
126008view13:41, 25 March 2023Rex D A B
126007view11:39, 25 March 2023Rex D A BMolecule rearrangement
126006view11:01, 25 March 2023Rex D A BPathway arrangement
126003view07:32, 25 March 2023Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
NFATC1GeneProduct4772 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
ATP6V0D2GeneProduct245972 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CCL20GeneProduct6364 (Entrez Gene)
COX2ProteinP00403 (Uniprot-TrEMBL)
CSF2GeneProduct1437 (Entrez Gene)
CTSKGeneProduct1513 (Entrez Gene)
CXCL8GeneProduct3576 (Entrez Gene)
Ccl20GeneProduct20297 (Entrez Gene)
Ccl3ProteinP10855 (Uniprot-TrEMBL)
Cd80GeneProduct12519 (Entrez Gene)
CsfGeneProduct12977 (Entrez Gene)
Cxcl2GeneProduct20310 (Entrez Gene)
DCSTAMPGeneProduct81501 (Entrez Gene)
DDIT3 ProteinP35638 (Uniprot-TrEMBL)
DEFB4GeneProduct1673 (Entrez Gene)
EPHA3 ProteinP29320 (Uniprot-TrEMBL)
Gene/ProteinRna
ICAM1GeneProduct3383 (Entrez Gene)
IL10GeneProduct3586 (Entrez Gene)
IL10R2ProteinQ08334 (Uniprot-TrEMBL)
IL17AGeneProduct3605 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1BProteinP01584 (Uniprot-TrEMBL)
IL20R1ProteinQ9UHF4 (Uniprot-TrEMBL)
IL26ProteinQ9NPH9 (Uniprot-TrEMBL)
IL33GeneProduct90865 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL6ProteinP05231 (Uniprot-TrEMBL)
IL8GeneProduct3576 (Entrez Gene)
IL8ProteinP10145 (Uniprot-TrEMBL)
Il10Protein16153 (Entrez Gene)
Il13GeneProduct16163 (Entrez Gene)
Il17aGeneProduct16171 (Entrez Gene)
Il33GeneProduct77125 (Entrez Gene)
Il4GeneProduct16189 (Entrez Gene)
Il6Protein16193 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
LigandProtein
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP1ProteinP03956 (Uniprot-TrEMBL)
MMP9GeneProduct4318 (Entrez Gene)
MPOProteinP05164 (Uniprot-TrEMBL)
Mmp2ProteinP33434 (Uniprot-TrEMBL)
Mmp9ProteinP41245 (Uniprot-TrEMBL)
MpoProteinP11247 (Uniprot-TrEMBL)
NFKBIAProtein4792 (Entrez Gene)
Nos2GeneProduct18126 (Entrez Gene)
OCSTAMPGeneProduct74614 (Entrez Gene)
PIK3CAProtein5290 (Entrez Gene)
ProteinProtein
RELAProtein5970 (Entrez Gene)
RELAProteinQ04206 (Uniprot-TrEMBL)
RORCGeneProduct6097 (Entrez Gene)
Receptor 1w (WikiPathways)
Receptor 2ProteinQ9UHF4 (Uniprot-TrEMBL)
SMAD2ProteinQ15796 (Uniprot-TrEMBL)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TGFB1ProteinP01137 (Uniprot-TrEMBL)
TNFGeneProduct7124 (Entrez Gene)
TNFProteinP01375 (Uniprot-TrEMBL)
TNFSF11 GeneProduct8600 (Entrez Gene)
TRAPGeneProduct100187907 (Entrez Gene)
TYK2Protein7297 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
cleaved CASP3GeneProduct836 (Entrez Gene)
mRNARna

Annotated Interactions

No annotated interactions

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