Osteoclast signaling (Homo sapiens)

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Revision as of 13:49, 16 April 2023 by Egonw (Talk | contribs)

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Description

Signaling pathways involved in osteoclast activation. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

Pathway Ontology : bone disease pathway

Disease : Adams-Oliver syndrome bone disease cleidocranial dysplasia Pallister-Hall syndrome polydactyly brachydactyly brachydactyly type A1 campomelic dysplasia acrocapitofemoral dysplasia syndactyly type 1 Robinow syndrome autosomal dominant Robinow syndrome 1 osteogenesis imperfecta spondylocostal dysostosis 1 split hand-foot malformation 6

Cell Type : osteoblast osteocyte chondrocyte

Bibliography

Boyle WJ, Simonet WS, Lacey DL; ''Osteoclast differentiation and activation.''; Nature, 2003 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
136867	view	05:38, 25 February 2025	Egonw	Modified description
126682	view	17:29, 11 June 2023	Egonw	Converted interaction type to mim-translocation
126213	view	13:49, 16 April 2023	Egonw
116896	view	11:25, 15 May 2021	Eweitz	Modified title
106572	view	21:19, 6 September 2019	Khanspers	Modified description
106216	view	12:11, 16 August 2019	MaintBot	HMDB identifier normalization
105767	view	19:37, 15 August 2019	Khanspers	Modified description
97823	view	15:29, 9 June 2018	Egonw	Undo revision 97754 by [[Special:Contributions/Jessev1993\|Jessev1993]] ([[User talk:Jessev1993\|Talk]]) Text cannot be copied from other websites.
97754	view	13:18, 7 June 2018	Jessev1993	Modified description
97753	view	13:17, 7 June 2018	Jessev1993	added references
88602	view	20:04, 11 August 2016	Mkutmon	fix unconnected lines
81176	view	13:30, 31 July 2015	Egonw	PubChem-compound ID for H+ (hydron) instead of the hydrogen radical.
78593	view	14:51, 7 January 2015	MaintBot	added missing graphIds
72135	view	08:17, 25 October 2013	Egonw	Added an identifier for Pi.
68910	view	17:30, 8 July 2013	MaintBot	Updated to 2013 gpml schema
67557	view	11:25, 26 June 2013	Ddigles	Ontology Term : 'signaling pathway pertinent to development' added !
59108	view	22:20, 21 February 2013	MaintBot	Updated Ensembl and UniProt data source
48235	view	05:51, 17 May 2012	MaintBot	Updating PubChem xrefs
48213	view	05:28, 17 May 2012	MaintBot	Automatic update of PubChem xrefs
45320	view	20:10, 7 October 2011	Khanspers	Ontology Term : 'signaling pathway' added !
45318	view	20:08, 7 October 2011	Khanspers	Ontology Term : 'osteoclast' added !
43865	view	23:57, 9 August 2011	Samuel Sklar	Specify description
43864	view	23:56, 9 August 2011	Samuel Sklar	Periodical save, work in progress
41056	view	23:17, 1 March 2011	MaintBot	Removed redundant pathway information and comments
39760	view	07:33, 17 January 2011	AlexanderPico	more specific title
38787	view	00:25, 24 September 2010	AlexanderPico
38786	view	00:24, 24 September 2010	AlexanderPico
38785	view	00:22, 24 September 2010	AlexanderPico
38784	view	00:21, 24 September 2010	AlexanderPico	Specify description
38783	view	00:20, 24 September 2010	AlexanderPico
38781	view	00:18, 24 September 2010	AlexanderPico	Specify description
38780	view	00:15, 24 September 2010	AlexanderPico	beautification
20697	view	11:29, 14 November 2008	MaintBot	[[Pathway:Homo sapiens:Osteoclasts]] moved to [[Pathway:WP12]]: Moved to stable identifier
14749	view	22:51, 23 May 2008	Ehsiao	Connected
10392	view	02:54, 25 January 2008	AlexanderPico	added id for na+/h+ transporter
10391	view	02:46, 25 January 2008	AlexanderPico	updated identifiers and data types
10390	view	02:41, 25 January 2008	AlexanderPico	updating identifiers and data types
10358	view	03:01, 23 January 2008	AlexanderPico	Modified categories
10335	view	01:33, 23 January 2008	Ehsiao	GPML Import (Author=Grant Yang)

External references

DataNodes

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Name	Type	Database reference
AIMP2	GeneProduct	ENSG00000106305 (Ensembl)
Ca2+	Metabolite	271 (PubChem-compound)
Cathepsin K	Protein	1513 (Entrez Gene)
H+ ATPase	Protein	9550 (Entrez Gene)
H+	Metabolite	1038 (PubChem-compound)
IFN-b	Protein	3456 (Entrez Gene)
MAPK8	GeneProduct	ENSG00000107643 (Ensembl)
Na+/H+ transporter	Protein	6548 (Entrez Gene)
Na+	Metabolite	HMDB0000588 (HMDB)
OGR1	Protein	8111 (Entrez Gene)
OPG	Protein	4982 (Entrez Gene)
Osteopontin	Protein	6696 (Entrez Gene)
PDGFB	Protein	5155 (Entrez Gene)
Pi	Metabolite	CHEBI:35780 (ChEBI)
RANK ligand	Protein	8600 (Entrez Gene)
RANK	Protein	8792 (Entrez Gene)
TRAP	Protein	54 (Entrez Gene)
TRPV	Protein	56302 (Entrez Gene)
Type 1 interferon receptor	Protein	3454 (Entrez Gene)
b3 integrin	Protein	3690 (Entrez Gene)