JAK-STAT signaling in the regulation of beta cells (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ProliferationBeta-cellIL6IFNGPRLREPOMAPK signaling pathwayGHRJAK2GH1EPORIL6RPRLRPTORMLST8AKT1S1MTORKRASNRASHRASFOXM1CCND1CCND3CCND2CDK4SOCS2SOCS1CISHSOCS3AKT2AKT3AKT1STAT1JAK2IFNGR2IFNGR1STAT3JAK2STAT5BSTAT5ASTAT5AName: JAK-STAT signaling in the regulation of Beta-cellsOrganism: Homo sapiens


Description

JAK-STAT signaling in Beta-cells

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Pathway Ontology : Jak-Stat signaling pathway
 

Bibliography

  1. Jiang WJ, Peng YC, Yang KM; ''Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes.''; Exp Ther Med, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135254
Approved
view10:53, 9 August 2024EweitzRefine state positions
135253view10:51, 9 August 2024EweitzEconomize layout
135252view10:43, 9 August 2024EweitzEconomize layout
128435view18:05, 4 February 2024EweitzModified title
128434view18:05, 4 February 2024EweitzCopyedit
127191view11:22, 10 August 2023IsabelWassinkchanged identifiers to EntrezGene
127190view10:33, 10 August 2023IsabelWassinkupdated the visualization of the groups
126368view17:45, 25 April 2023EgonwMade a pathway clickable
126367view11:17, 25 April 2023IsabelWassinkchanged an arrow to mim-modification
126359view10:31, 24 April 2023IsabelWassinkupdated wrong mim-interaction
126299view12:32, 20 April 2023IsabelWassinkAdded P for phosphorylation
126297view11:09, 20 April 2023IsabelWassinkModified description
126294view09:49, 20 April 2023IsabelWassinkModified description
126293view09:41, 20 April 2023IsabelWassinkOntology Term : 'type B pancreatic cell' added !
126292view09:39, 20 April 2023IsabelWassinkOntology Term : 'Jak-Stat signaling pathway' added !
126291view09:30, 20 April 2023IsabelWassinkModified description
126290view09:21, 20 April 2023IsabelWassinkNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProductENSG00000142208 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCND2GeneProductENSG00000118971 (Ensembl)
CCND3GeneProductENSG00000112576 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CISHGeneProductENSG00000114737 (Ensembl)
EPOGeneProductENSG00000130427 (Ensembl)
EPORGeneProductENSG00000187266 (Ensembl)
FOXM1GeneProductENSG00000111206 (Ensembl)
GH1GeneProductENSG00000259384 (Ensembl)
GHRGeneProductENSG00000112964 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IFNGR1GeneProductENSG00000027697 (Ensembl)
IFNGR2GeneProductENSG00000159128 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL6RGeneProductENSG00000160712 (Ensembl)
JAK2GeneProductENSG00000096968 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK signaling pathwayPathwayWP382 (WikiPathways)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PRLGeneProductENSG00000172179 (Ensembl)
PRLRGeneProductENSG00000113494 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
SOCS1GeneProductENSG00000185338 (Ensembl)
SOCS2GeneProductENSG00000120833 (Ensembl)
SOCS3GeneProductENSG00000184557 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)

Annotated Interactions

No annotated interactions

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