JAK-STAT signaling in the regulation of beta cells (Homo sapiens)

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1ProliferationBeta-cellSTAT5APRLRMTORAKT1S1AKT1IL6RIFNGKRASCDK4RPTORAKT3EPORGH1CCND2CCND3AKT2STAT1PRLIFNGR2IFNGR1CCND1HRASMLST8NRASSTAT5BSTAT3SOCS3MAPK signaling pathwaySOCS1SOCS2GHRFOXM1CISHIL6EPOJAK2JAK2JAK2STAT5A


Description

JAK-STAT signaling participates in the regulation of key biological processes in Beta-cells, including cell proliferation. Janus kinases (JAKs) serve as a fundamental switch that trigger signal transducer and activator of transcription (STAT) proteins through phosphorylation, which enables downstream target activation and subsequent regulation of target gene transcription. Suppressors of cytokine signaling (SOCS) are negative modulators of JAK-STAT signaling. This pathway is based on a figure by Jiang et al. (2018, PMID: 30233674).

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Ontology Terms

 

Bibliography

  1. Jiang WJ, Peng YC, Yang KM; ''Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes.''; Exp Ther Med, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135254view10:53, 9 August 2024EweitzRefine state positions
135253view10:51, 9 August 2024EweitzEconomize layout
135252view10:43, 9 August 2024EweitzEconomize layout
128435view18:05, 4 February 2024EweitzModified title
128434view18:05, 4 February 2024EweitzCopyedit
127191view11:22, 10 August 2023IsabelWassinkchanged identifiers to EntrezGene
127190view10:33, 10 August 2023IsabelWassinkupdated the visualization of the groups
126368view17:45, 25 April 2023EgonwMade a pathway clickable
126367view11:17, 25 April 2023IsabelWassinkchanged an arrow to mim-modification
126359view10:31, 24 April 2023IsabelWassinkupdated wrong mim-interaction
126299view12:32, 20 April 2023IsabelWassinkAdded P for phosphorylation
126297view11:09, 20 April 2023IsabelWassinkModified description
126294view09:49, 20 April 2023IsabelWassinkModified description
126293view09:41, 20 April 2023IsabelWassinkOntology Term : 'type B pancreatic cell' added !
126292view09:39, 20 April 2023IsabelWassinkOntology Term : 'Jak-Stat signaling pathway' added !
126291view09:30, 20 April 2023IsabelWassinkModified description
126290view09:21, 20 April 2023IsabelWassinkNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCND2GeneProductENSG00000118971 (Ensembl)
CCND3GeneProductENSG00000112576 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CISHGeneProductENSG00000114737 (Ensembl)
EPOGeneProductENSG00000130427 (Ensembl)
EPORGeneProductENSG00000187266 (Ensembl)
FOXM1GeneProductENSG00000111206 (Ensembl)
GH1GeneProductENSG00000259384 (Ensembl)
GHRGeneProductENSG00000112964 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IFNGR1GeneProductENSG00000027697 (Ensembl)
IFNGR2GeneProductENSG00000159128 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL6RGeneProductENSG00000160712 (Ensembl)
JAK2GeneProductENSG00000096968 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK signaling pathwayPathwayWP382 (WikiPathways)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PRLGeneProductENSG00000172179 (Ensembl)
PRLRGeneProductENSG00000113494 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
SOCS1GeneProductENSG00000185338 (Ensembl)
SOCS2GeneProductENSG00000120833 (Ensembl)
SOCS3GeneProductENSG00000184557 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)

Annotated Interactions

No annotated interactions

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