Smith-Magenis and Potocki-Lupski syndrome copy number variation (Homo sapiens)

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IRF8PITPK1PJUNPTFE3PTFEBPPTENCRY1P87, 884959392, 9324574257899515, 587964964446949080443527, 709471911397461327, 7015, 5865465786391869697773, 7467, 7773, 7481674820393, 286973, 74318376412659, 68861931383, 16, 17, 53181910, 61, 6659, 68307616, 17, 53308, 8110, 863832, 5284523, 6938, 60338436, 51763973, 7459, 688, 81674725765061, 66377822, 5657546, 12556533, 512, 216422716455, 6329, 645637721, 79826, 1234, 36711433, 517, 4362822164751533, 51Endosome mitochondrial fusionspecific functionunknowninactive state homeostatic functions such as feeding, sleeping and temperaturebut also role in inflammation and pain Mitochondrial fissionregulation of cytoskeleton regulation of endothelial senescencetraffics and delivers critical molecules required for stereocilia development Initiation of chromosomalDNA replication Axonogenesismitochondrial fission assembly of the axoneme during spermiogenesis late meiotic and haploid phases of spermatogenesisRNA stability and cellular stress responseregulation of epithelial cell polarityGluconeogenesisMidbrain dopaminergic neurogenesisdecatenation and segregation of mtDNA synthesis of methionine, thymidylate, and purines in the cytoplasm.plasma cell differentiation45, 64Protects mitochondrial DNA replication from excess dTTPincrease and stabilization of actin filaments 22, 56cytochrome C releaselipin familyYAP1Autophagycell cyclePRKAA1TFEBdiacylglycerolPDMETFE3UBP8Phosphatidylcholine catabolismThymine Core mediatorcomplex AMPK complexUracilLDHAsynaptogenesis and neurogenesisPESTAT3APPMYCE3 ubiquitin ligasesignalling pathwayMTORC1TP53PiRNA biogenesisMTOR signalling AP-1 familyMicrotubule cytoskeleton regulationRRAGAcardiolipinFE65MIGA1glycolysisRNA polymerase II FHOD1noncanonical NF-kB pathwayCREB1phosphatidate MLST8PCARM1C9orf72-SMCR8 MAEADRC1PRKNUbC9ORF72NR1H3TLR4Fatty acid synthesis Intraflagellartransport complex BRAB8AGDP MLST8RNF41 NFKB1IFT81PCK1ROSNR1H2TNF-α signalingpathway TOLLIPmRNA WDR41LRRC48RO60MYH2CLTCTNFAutophagyGRIP1PARD6BMPRIPATP synthasecomplexMitophagyPAR cellpolarity complexNF-κB P50/P65 CLTASREB2HBP1UbMYO16ARG2PEMTSMCR8DRP1GDI2FOXA1NT5MFNIP2TNFRSF13B40cortisolCOPS3MAP3K14Zinc 2+ ATPAF2MYPT1PHomologous recombinationRAI1BAFFPRDM1GID4ALKBH5DRG2TBC1D27BAX21MIEF2CLEC16ACFL2PTOP3AFLIICRY1RASD1BCL2L11CRY2one-carbon compoundTOM1L2PER1CRY2PPER1PFLCNCOP9signalosomeROCK175LIMK1P2, 21BMLL-serineTNFSF13RMI2MYO15ARMI1ApoptosisTOP3AApoptosisBMAL1melatoninRhoAglycineMagnesium 2+SREBF1BTR complexMED9CDK1 BIRC2BCL6LLGL1CFL2pyridoxal 5'-phosphate(2-)CLOCKSHMT1PRKNRP1-178F10.3SMCR8RAB8AGTP RAB39BGTPRAB39BGDPULK1RB1CC1ATG13ATG101RPL21P121RP1-178F10.3RP1-178F10.1RP11-258F1.1ULK1 complexRPTORMTORMTORC185MYD888MYD88RELA81IL1BPRKCIPARD3RAB10RAB10mRNA MesnoU13AC087163.2Y RNAAC087163.3DRC3CCDC65GAS8TCTE1FBXL13DRC7EFCAB2IQCGIQCDIQCA169IFT7469IFT22IFT22IFT81IFT74TTC26IFT46IFT52IFT172IFT80IFT88TTC30BIFT57CLUAP1IFT20IFT27IFT25TRAF3IP16969AC122129.1TOM1L2CLTCCLTCCLTACLTB4952MIR33BG6PC1FOXA2HES6FERD3LRP1-253P7.1SMCR5RAI1-AS1MKLN1ARMC8WDR26RMND5ARANBP9GID4HBP1SMCR2RP11-524F11.2RNU6-468PRP11-524F11.1Y RNA TSEN15P1AC073621.2RPL13P12UracilPThymine AC055811.1AC055811.5RP11-45M22.5RP11-45M22.4PLD6MIGA2PRKAG2PRKAB1WWTR1RN7SL775PRNU6-767PRP11-45M22.3MPRIP-AS1ETV5PPP1R14ARP11-416I2.1AC104024.2AC104024.1TNFRSF13BTNFRSF13BFLCNFLCNFNIP1RPTORMTORCOPS7ACOPS5COPS6COPS8COPS3COPS2COPS4GPS1Zinc 2+ TP53PJUNITPK187, 88IRF888MED9PMMEphosphatidylcholine92, 9392, 9392, 9392, 9392, 93CREBP


Description

The Smith-Magenis syndrome, is the result from a deletion of chr17:chr17:16,82-18,28, while the Potocki-Lupski syndrome is the result of a duplication of this area.

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  94. Ono M, Ando H, Daikoku T, Fujiwara T, Mieda M, Mizumoto Y, Iizuka T, Kagami K, Hosono T, Nomura S, Toyoda N, Sekizuka-Kagami N, Maida Y, Kuji N, Nishi H, Fujiwara H; ''The Circadian Clock, Nutritional Signals and Reproduction: A Close Relationship.''; Int J Mol Sci, 2023 PubMed Europe PMC Scholia
  95. Huang H, Gao Q, Peng X, Choi SY, Sarma K, Ren H, Morris AJ, Frohman MA; ''piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling.''; Dev Cell, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134446view23:53, 21 July 2024EweitzOntology Term : 'Potocki-Lupski syndrome' added !
134445view23:52, 21 July 2024EweitzOntology Term : 'Smith-Magenis syndrome' added !
134396view19:45, 21 July 2024EweitzRemove template comments
127624view20:29, 8 November 2023LarsgwRemove duplicate references
127450view18:30, 3 October 2023Khanspersconverted interactions in legend to graphical lines
127076view16:37, 27 July 2023Fehrhartcorrection and update in progress
127075view16:17, 27 July 2023FehrhartOntology Term : 'disease pathway' added !
127004view14:06, 17 July 2023Ash iyerData nodes annotation updated.
126969view19:06, 9 July 2023Ninagerrekens
126924view14:23, 6 July 2023EgonwReplaced SwissProt with TrEMBL
126891view09:39, 30 June 2023EgonwAdding some missing reference data
126890view09:38, 30 June 2023Egonw'Complex Portal' data source
126686view22:31, 12 June 2023NinagerrekensNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AC055811.1GeneProductENSG00000265109 (Ensembl) MiRNA
AC055811.5GeneProductENSG00000226359 (Ensembl)
AC073621.2GeneProductENSG00000227158 (Ensembl)
AC087163.2GeneProductENSG00000232344 (Ensembl)
AC087163.3GeneProductENSG00000230273 (Ensembl)
AC104024.1GeneProductENSG00000230709 (Ensembl) LincRNA
AC104024.2GeneProductENSG00000230969 (Ensembl) LincRNA
AC122129.1GeneProductENSG00000197815 (Ensembl)
ALKBH5GeneProductENSG00000091542 (Ensembl)
AMPK complexComplexCPX-5786 (ChEBI)
AP-1 familyProteinIPR000837 (Uniprot-TrEMBL)
APPProteinP05067 (Uniprot-TrEMBL)
ARG2ProteinP78540 (Uniprot-TrEMBL)
ARMC8ProteinQ8IUR7 (Uniprot-TrEMBL)
ATG101ProteinQ9BSB4 (Uniprot-TrEMBL)
ATG13ProteinO75143 (Uniprot-TrEMBL)
ATP synthase complexComplexCPX-6151 (ChEBI)
ATPAF2GeneProductENSG00000171953 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
BAFFProteinQ8JHJ4 (Uniprot-TrEMBL) Blys is a synonym
BAXProteinQ07812 (Uniprot-TrEMBL)
BCL2L11ProteinO43521 (Uniprot-TrEMBL) also known as BCL2L11
BCL6ProteinA0A0C4DH53 (Uniprot-TrEMBL)
BIRC2ProteinE9PI77 (Uniprot-TrEMBL) cIAP-1 is a synonym for BIRC2
BMAL1ProteinO00327 (Uniprot-TrEMBL)
BMLProteinP54132 (Uniprot-TrEMBL)
BTR complexComplexCPX-3301 (ChEBI)
C9ORF72ProteinQ96LT7 (Uniprot-TrEMBL)
C9orf72-SMCR8 ComplexCPX-3961 (ChEBI)
CARM1ProteinQ86X55 (Uniprot-TrEMBL)
CCDC65ProteinQ8IXS2 (Uniprot-TrEMBL)
CDK1 ProteinP06493 (Uniprot-TrEMBL)
CFL2ProteinQ9Y281 (Uniprot-TrEMBL)
CLEC16AProteinQ2KHT3 (Uniprot-TrEMBL)
CLOCKProteinO15516 (Uniprot-TrEMBL)
CLTAProteinP09496 (Uniprot-TrEMBL) Clathrin a
CLTBProteinP09497 (Uniprot-TrEMBL) Clathrin a
CLTCProteinQ00610 (Uniprot-TrEMBL)
CLUAP1ProteinQ96AJ1 (Uniprot-TrEMBL)
COP9 signalosomeComplexCPX-1870 (ChEBI)
COPS2ProteinP61201 (Uniprot-TrEMBL)
COPS3GeneProductENSG00000141030 (Ensembl)
COPS3ProteinQ9UNS2 (Uniprot-TrEMBL)
COPS4ProteinQ9BT78 (Uniprot-TrEMBL)
COPS5ProteinQ92905 (Uniprot-TrEMBL)
COPS6ProteinQ7L5N1 (Uniprot-TrEMBL)
COPS7AProteinQ9UBW8 (Uniprot-TrEMBL)
COPS8ProteinQ99627 (Uniprot-TrEMBL)
CREB1ProteinENSG00000118260 (Ensembl)
CREBProteinENSG00000118260 (Ensembl)
CRY1Protein
CRY1ProteinQ16526 (Uniprot-TrEMBL)
CRY2Protein
CRY2ProteinQ49AN0 (Uniprot-TrEMBL)
Core mediator complex ComplexCPX-3227 (ChEBI)
DRC1ProteinQ96MC2 (Uniprot-TrEMBL)
DRC3ProteinQ9H069 (Uniprot-TrEMBL) Is protein of LRRC48
DRC7ProteinQ8IY82 (Uniprot-TrEMBL)
DRG2GeneProductENSG00000108591 (Ensembl)
DRP1ProteinO43583 (Uniprot-TrEMBL)
E3 ubiquitin ligase signalling pathwayPathwayWP4055 (WikiPathways)
EFCAB2ProteinQ5VUJ9 (Uniprot-TrEMBL)
ETV5ProteinP41161 (Uniprot-TrEMBL)
FBXL13ProteinQ8NEE6 (Uniprot-TrEMBL)
FE65ProteinO00213 (Uniprot-TrEMBL)
FERD3LProteinQ96RJ6 (Uniprot-TrEMBL)
FHOD1ProteinQ9Y613 (Uniprot-TrEMBL)
FLCNGeneProductENSG00000154803 (Ensembl)
FLIIGeneProductENSG00000177731 (Ensembl)
FNIP1ProteinQ8TF40 (Uniprot-TrEMBL)
FNIP2ProteinQ9P278 (Uniprot-TrEMBL)
FOXA1ProteinP55317 (Uniprot-TrEMBL)
FOXA2ProteinQ9Y261 (Uniprot-TrEMBL)
Fatty acid synthesis PathwayWP357 (WikiPathways)
G6PC1ProteinP35575 (Uniprot-TrEMBL)
GAS8ProteinO95995 (Uniprot-TrEMBL)
GDI2ProteinP50395 (Uniprot-TrEMBL)
GID4GeneProductENSG00000141034 (Ensembl)
GID4ProteinQ8IVV7 (Uniprot-TrEMBL)
GPS1ProteinQ13098 (Uniprot-TrEMBL)
GRIP1ProteinQ9Y3R0 (Uniprot-TrEMBL)
HBP1ProteinO60381 (Uniprot-TrEMBL)
HES6ProteinQ96HZ4 (Uniprot-TrEMBL)
Homologous recombinationPathwayWP5096 (WikiPathways)
IFT172ProteinQ9UG01 (Uniprot-TrEMBL)
IFT20ProteinQ8IY31 (Uniprot-TrEMBL)
IFT22ProteinQ9H7X7 (Uniprot-TrEMBL)
IFT25ProteinQ9Y547 (Uniprot-TrEMBL)
IFT27ProteinQ9BW83 (Uniprot-TrEMBL)
IFT46ProteinQ9NQC8 (Uniprot-TrEMBL)
IFT52ProteinQ9Y366 (Uniprot-TrEMBL)
IFT57ProteinQ9NWB7 (Uniprot-TrEMBL)
IFT74ProteinQ96LB3 (Uniprot-TrEMBL)
IFT80ProteinQ9P2H3 (Uniprot-TrEMBL)
IFT81ProteinQ8WYA0 (Uniprot-TrEMBL)
IFT88ProteinQ13099 (Uniprot-TrEMBL)
IL1BProteinP01584 (Uniprot-TrEMBL) proinflammatory cytokine
IQCA1ProteinQ86XH1 (Uniprot-TrEMBL)
IQCDProteinQ96DY2 (Uniprot-TrEMBL)
IQCGProteinQ9H095 (Uniprot-TrEMBL)
IRF8ProteinQ02556 (Uniprot-TrEMBL)
ITPK1ProteinQ13572 (Uniprot-TrEMBL)
Intraflagellar transport complex BComplexCPX-5022 (ChEBI)
JUNProteinP05412 (Uniprot-TrEMBL)
L-serineMetabolite33384 (ChEBI)
LDHAProteinP00338 (Uniprot-TrEMBL)
LIMK1ProteinP53667 (Uniprot-TrEMBL)
LLGL1GeneProductENSG00000131899 (Ensembl)
LRRC48GeneProductENSG00000171962 (Ensembl)
MAEAProteinQ7L5Y9 (Uniprot-TrEMBL)
MAP3K14ProteinQ99558 (Uniprot-TrEMBL) NIK is short for NF-κB-inducing kinase
MED9GeneProductENSG00000141026 (Ensembl)
MIEF2GeneProductENSG00000177427 (Ensembl) outer mitochondrial membrane
MIGA1ProteinQ8NAN2 (Uniprot-TrEMBL)
MIGA2ProteinQ7L4E1 (Uniprot-TrEMBL)
MIR33BGeneProductENSG00000207839 (Ensembl) MiRNA
MKLN1ProteinQ9UL63 (Uniprot-TrEMBL)
MLST8ProteinQ9BVC4 (Uniprot-TrEMBL)
MPRIP-AS1GeneProductENSG00000225442 (Ensembl) antisense
MPRIPGeneProductENSG00000133030 (Ensembl) KIAA0864, M-RIP, MRIP, RHOIP3, RIP3, p116Rip are other names for MPRIP
MTOR signalling PathwayWP3318 (WikiPathways)
MTORC1ComplexCPX-503 (ChEBI)
MTORProteinP42345 (Uniprot-TrEMBL)
MYCProteinP01106 (Uniprot-TrEMBL)
MYD88ProteinQ99836 (Uniprot-TrEMBL)
MYH2ProteinQ9UKX2 (Uniprot-TrEMBL)
MYO15AGeneProductENSG00000091536 (Ensembl) expressed in hair cells of the inner ear
MYO16ProteinQ9Y6X6 (Uniprot-TrEMBL)
MYPT1ProteinO14974 (Uniprot-TrEMBL)
Magnesium 2+Metabolite18420 (ChEBI)
Microtubule cytoskeleton regulationPathwayWP2038 (WikiPathways)
MitophagyPathwayWP3549 (WikiPathways)
NF-κB P50/P65 ComplexCPX-5828 (ChEBI)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NR1H2ProteinP55055 (Uniprot-TrEMBL)
NR1H3ProteinQ13133 (Uniprot-TrEMBL)
NT5MGeneProductENSG00000205309 (Ensembl)
PAR cell polarity complexComplexCPX-6193 (ChEBI)
PARD3ProteinQ8TEW0 (Uniprot-TrEMBL)
PARD6BProteinQ9BYG5 (Uniprot-TrEMBL)
PCK1ProteinP35558 (Uniprot-TrEMBL)
PDMEMetabolite64572 (ChEBI)
PEMetabolite16038 (ChEBI)
PEMTGeneProductENSG00000133027 (Ensembl)
PER1Protein
PER1ProteinO15534 (Uniprot-TrEMBL)
PLD6GeneProductENSG00000179598 (Ensembl)
  • ZUC and MitoPLD are different names for PLD6
  • Type your comment here
PMMEMetabolite64573 (ChEBI)
PPP1R14AProteinQ96A00 (Uniprot-TrEMBL)
PRDM1ProteinO75626 (Uniprot-TrEMBL)
PRKAA1ProteinQ13131 (Uniprot-TrEMBL)
PRKAB1ProteinQ9Y478 (Uniprot-TrEMBL)
PRKAG2ProteinQ9UGJ0 (Uniprot-TrEMBL)
PRKCIProteinP41743 (Uniprot-TrEMBL)
PRKNProteinO60260 (Uniprot-TrEMBL)
PTENProteinP60484 (Uniprot-TrEMBL)
Phosphatidylcholine catabolismPathwayWP4195 (WikiPathways)
PiRNA biogenesisPathwayR-HSA-5601884 (Reactome)
RAB10ProteinP61026 (Uniprot-TrEMBL)
RAB39BProteinQ96DA2 (Uniprot-TrEMBL)
RAB8AProteinP61006 (Uniprot-TrEMBL)
RAI1-AS1GeneProductENSG00000237328 (Ensembl) antisense
RAI1GeneProductENSG00000108557 (Ensembl)
RANBP9ProteinQ96S59 (Uniprot-TrEMBL)
RASD1GeneProductENSG00000108551 (Ensembl)
RB1CC1ProteinQ8TDY2 (Uniprot-TrEMBL) FIP200
RELAProteinQ04206 (Uniprot-TrEMBL)
RMI1ProteinQ9H9A7 (Uniprot-TrEMBL)
RMI2ProteinQ96E14 (Uniprot-TrEMBL)
RMND5AProteinQ9H871 (Uniprot-TrEMBL)
RN7SL775PGeneProductENSG00000243370 (Ensembl) Misc RNA
RNA polymerase II PathwayWP4933 (WikiPathways)
RNF41 ProteinQ9H4P4 (Uniprot-TrEMBL)
RNU6-468PGeneProductENSG00000206730 (Ensembl) SnRNA
RNU6-767PGeneProductENSG00000206859 (Ensembl) SnRNA
RO60ProteinP10155 (Ensembl)
ROCK1ProteinQ13464 (Uniprot-TrEMBL)
ROSMetabolite26523 (ChEBI)
RP1-178F10.1GeneProductENSG00000260647 (Ensembl) Antisense
RP1-178F10.3GeneProductENSG00000267350 (Ensembl)
RP1-253P7.1GeneProductENSG00000264167 (Ensembl) sense intronic
RP11-258F1.1GeneProductENSG00000266677 (Ensembl) Antisense
RP11-416I2.1GeneProductENSG00000260328 (Ensembl) LincRNA
RP11-45M22.3GeneProductENSG00000263624 (Ensembl) antisense
RP11-45M22.4GeneProductENSG00000264187 (Ensembl)
RP11-45M22.5GeneProductENSG00000266498 (Ensembl) LincRNA
RP11-524F11.1GeneProductENSG00000265511 (Ensembl) antisense
RP11-524F11.2GeneProductENSG00000264666 (Ensembl) antisense
RPL13P12GeneProductENSG00000215030 (Ensembl)
RPL21P121GeneProductENSG00000237382 (Ensembl)
RPTORProteinQ8N122 (Uniprot-TrEMBL)
RRAGAProteinQ7L523 (Uniprot-TrEMBL)
RhoAProteinP61586 (Uniprot-SwissProt)
SHMT1GeneProductENSG00000176974 (Ensembl)
SMCR2GeneProductENSG00000223979 (Ensembl) LincRNA
SMCR5GeneProductENSG00000226746 (Ensembl) antisense
SMCR8GeneProductENSG00000176994 (Ensembl)
SMCR8ProteinQ8TEV9 (Uniprot-TrEMBL)
SREB2ProteinP60893 (Uniprot-TrEMBL)
SREBF1GeneProductENSG00000072310 (Ensembl)
STAT3ProteinP40763 (Uniprot-TrEMBL)
TBC1D27GeneProductENSG00000128438 (Ensembl)
TCTE1ProteinQ5JU00 (Uniprot-TrEMBL)
TFE3ProteinP19532 (Uniprot-TrEMBL)
TFEBProteinP19484 (Uniprot-TrEMBL)
TLR4ProteinO00206 (Uniprot-TrEMBL)
TNF-α signaling pathway PathwayWP231 (WikiPathways)
TNFProteinP01375 (Uniprot-TrEMBL)
TNFRSF13BGeneProductENSG00000240505 (Ensembl)
  • CD267, CVID, CVID2, RYZN, TACI, TNFRSF14B are synonyms
  • expressed on CD27+ B memory cells
  • receptor for TNFSF 13 and BAFF
TNFSF13ProteinO75888 (Uniprot-TrEMBL) APRIL is a synonym of TNFSF13
TOLLIPProteinQ9H0E2 (Uniprot-TrEMBL)
TOM1L2GeneProductENSG00000175662 (Ensembl)
TOM1L2ProteinQ6ZVM7 (Uniprot-SwissProt)
TOP3AGeneProductENSG00000177302 (Ensembl)
TOP3AProteinQ13472 (Uniprot-TrEMBL)
TP53ProteinP04637 (Uniprot-TrEMBL)
TRAF3IP1ProteinQ8TDR0 (Uniprot-TrEMBL)
TSEN15P1GeneProductENSG00000230865 (Ensembl)
TTC26ProteinA0AVF1 (Uniprot-TrEMBL)
TTC30BProteinQ8N4P2 (Uniprot-TrEMBL)
Thymine Metabolite17821 (ChEBI)
UBP8ProteinP40818 (Uniprot-TrEMBL)
ULK1 complexCPX-373 (ChEBI)
ULK1ProteinO75385 (Uniprot-TrEMBL)
UracilMetabolite17568 (ChEBI)
WDR26ProteinQ9H7D7 (Uniprot-TrEMBL)
WDR41ProteinQ9HAD4 (Uniprot-TrEMBL)
WWTR1ProteinQ9GZV5 (Uniprot-TrEMBL)
Y RNA GeneProductENSG00000201741 (Ensembl) Misc RNA
Y RNAGeneProductENSG00000201378 (Ensembl) misc RNA
YAP1ProteinP46937 (Uniprot-TrEMBL)
Zinc 2+ Metabolite29105 (ChEBI)
cardiolipinMetabolite28494 (ChEBI)
cell cyclePathwayWP179 (WikiPathways)
cortisolMetabolite17650 (ChEBI)
diacylglycerolMetabolite85694 (ChEBI)
glycineMetabolite57305 (ChEBI)
glycolysisPathwayWP534 (WikiPathways)
lipin familyProteinIPR026058 (InterPro)
mRNA Metabolite33699 (ChEBI) demethylation of N6-methyladenosine (m6A)
melatoninMetabolite16796 (ChEBI)
noncanonical NF-kB pathwayPathwayR-HSA-5676590 (Reactome)
one-carbon compoundMetabolite64708 (ChEBI)
phosphatidate Metabolite57739 (ChEBI)
phosphatidylcholineMetabolite64482 (ChEBI)
pyridoxal 5'-phosphate(2-)Metabolite597326 (ChEBI) cofactor
snoU13GeneProductENSG00000238691 (Ensembl) Antisense
synaptogenesis and neurogenesisPathwayWP5231 (WikiPathways)

Annotated Interactions

No annotated interactions

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