DNA adduct formation leading to kidney failure (Homo sapiens)

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DNA adduct formationDNA damage responseDNA damageCell deathInflammationFibrosisKidney failureDNA repair pathwaysApoptosisApoptosis modulation and signalingCollagen biosynthesis and modifying enzymesOverview of proinflammatory and profibrotic mediatorsType II interferon signalingTNF-alpha signaling pathway


Description

Adverse Outcome Pathway of DNA adduct formation leading to kidney failure. Stressors of this AOP include cisplatin and carboplatin.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
134444view23:51, 21 July 2024EweitzOntology Term : 'kidney failure' added !
134443view23:51, 21 July 2024EweitzOntology Term : 'kidney disease pathway' added !
126906view10:17, 1 July 2023EgonwOntology Term : 'disease pathway' added !
126866view09:14, 28 June 2023Marvin M2Ontology Term : 'kidney disease' added !
126752view13:47, 18 June 2023Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Apoptosis modulation and signalingPathwayWP1772 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
Cell death
Collagen biosynthesis and modifying enzymesPathwayWP2725 (WikiPathways)
DNA adduct formation
DNA damage
DNA damage responsePathwayWP707 (WikiPathways)
DNA repair pathwaysPathwayWP4946 (WikiPathways)
Fibrosis
Inflammation
Kidney failure
Overview of proinflammatory and profibrotic mediatorsPathwayWP5095 (WikiPathways)
TNF-alpha signaling pathwayPathwayWP231 (WikiPathways)
Type II interferon signalingPathwayWP619 (WikiPathways)

Annotated Interactions

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Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5389"
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