TAR syndrome (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Lys-48 and/or Lys-63 linkedMaintaining normal cholesterol levelsProgressivelyDNAIn activated NK cellsOn NK cellsSensesMulti drug resistanceNF-κBDuring viral infectionCostimulatory signals toactivated/memory CD8+ T-cellsRNA polymeraseMost probably non-functionalReceptor for classical andnon-classical MHCI moleculesHydrolysisIn the brush border of the proximal tubule of the kidneyFormation of proapoptotic isoformsType I IFNsAngiogenesisSubstratesStabilizingCluster proteins, modulate theirtrafficking and activityFunction unknownSplicing modulationOn activated CD4+ T-cellsIn HSCsDuring bacterial infectionPersistentVoltage dependent anion channel required foracidification and functions of the Golgi apparatusthat may function in counter-ion conductanceNucleoside diphosphate derivativesOn CD8+ T-cellsEJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAIn response to sensing of non-self RNAT-cell exhaustionNK cell cytotoxic activityTraps EJC onto spliced mRNABidirectional signallingRequired for pre-mRNA as component of the splicosomeIn immune privileged siteschr1:145,394,955E2 dependentIn activated T-cellsAntigenReceptor for collagenMembrane protrusion and elongationon the peroxisomal surfaceSLC26A6HLA-AGPR89ARNAEGFRBMPNonsense mediated decay pathwayCDKN1BMTA1Production of anti-microbial proteinsand inflammatory cytokinesGnRH-IIUBE2Inon-self dsDNATumour cell growthPeroxisome divisionMaturation of NK cellsTXNIPLCKIron homeostasisPI3KSignalling pathwaysABCC2PDZK1SCARB1TCR signallingIFNGPDZK1IP1CD160Proteasomal degradation of DDIT4METANKRD35TNFRSF14CollagenPOLR3CDNARNF115mTORC1CXCR4HFE2RNACCAR2FLT3DNM1LCD3EIF4A3ZFHX3JAK/STAT pathwayLymphocyte developmentPeroxisomal proliferationSTAT3CD247CFTRCD28 costimulatory signalingTXNHepcidinHLA-GHLA-CITGA10non-self RNARIG-I pathwaySIRT1GNRHR2ANKRD34APYM1POLR3GLRABL3RBM8ACOPS5BCL2L13SubstratePEX11BLIX1LPIAS3NUDT17DNASteroid hormone signalling pathwaySUMO1ZFHX3MAGOHRBM8APOLR3CPOLR3FPOLR3GViral peptideHLA-ABRF1TBPPDZK1NHERF1MTA1SCCAR2SSubstrateUCXCR4METFLT3EGFRUUUUSignalling pathwaysDuring viral infectionIn immune privileged sitesFunction unknownFunction unknownCatalysisBindingUbiquitinatedLEGENDInhibitionSumoylatedConversionStimulationUSName: TAROrganism: Homo sapiens


Description

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:Wplogo_31.pngCommunity: Rare Diseases

Ontology Terms

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
134655
Approved
RARE
view09:21, 24 July 2024EgonwCompleted a datasource
134452view00:02, 22 July 2024EweitzOntology Term : 'disease of mental health' added !
127046view09:38, 26 July 2023FehrhartOntology Term : 'Disease' added !
127045view09:38, 26 July 2023FehrhartOntology Term : 'disease pathway' added !
127044view09:37, 26 July 2023FehrhartModified description
127043view09:30, 26 July 2023Fehrhartcorrections and updates (done)
127042view07:47, 26 July 2023Fehrhartupdate in progress
127041view06:54, 26 July 2023Fehrhartupdate in progress
127029view13:11, 24 July 2023Fehrhartupdate
127028view12:36, 24 July 2023Fehrhartupgrade
127027view12:00, 24 July 2023Fehrhartupgrade
126901view14:14, 30 June 2023JmillanacostaChanged legend interactions and nodes to graphical objects
126849view09:37, 27 June 2023Ewoud
126578view15:20, 4 June 2023Ewoudfiller
126517view15:21, 23 May 2023EwoudNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ABCC2GeneProductENSG00000023839 (Ensembl)
ANKRD34AGeneProductENSG00000181039 (Ensembl)
ANKRD35GeneProductENSG00000198483 (Ensembl)
BCL2L13GeneProductENSG00000099968 (Ensembl)
BMPMetaboliteCHEBI:60815 (ChEBI)
BRF1GeneProductENSG00000185024 (Ensembl)
CCAR2GeneProductENSG00000158941 (Ensembl)
CD160GeneProductENSG00000117281 (Ensembl)
CD247GeneProductENSG00000198821 (Ensembl)
CD28 costimulatory signalingPathway
CD3GeneProductENSG00000167286 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CFTRGeneProductENSG00000001626 (Ensembl)
COPS5GeneProductENSG00000121022 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
CollagenMetaboliteCHEBI:3815 (ChEBI)
DNAGeneProduct
DNM1LGeneProductENSG00000087470 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4A3GeneProductENSG00000141543 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
GNRHR2GeneProductENSG00000211451 (Ensembl)
GPR89AGeneProductENSG00000117262 (Ensembl)
GnRH-IIMetaboliteCHEBI:80298 (ChEBI)
HFE2GeneProductENSG00000168509 (Ensembl)
HLA-AGeneProductENSG00000206503 (Ensembl)
HLA-CGeneProductENSG00000204525 (Ensembl)
HLA-GGeneProductENSG00000204632 (Ensembl)
HepcidinMetaboliteHMDB0259694 (HMDB)
IFNGGeneProductENSG00000111537 (Ensembl)
ITGA10GeneProductENSG00000143127 (Ensembl)
Iron homeostasisPathway
JAK/STAT pathwayPathwaymap04630 (KEGG Pathway)
LCKGeneProductENSG00000182866 (Ensembl)
LIX1LGeneProductENSG00000152022 (Ensembl)
Lymphocyte developmentPathway
MAGOHGeneProductENSG00000162385 (Ensembl)
METGeneProductENSG00000105976 (Ensembl)
MTA1GeneProductENSG00000182979 (Ensembl)
Maturation of NK cellsPathway
NHERF1GeneProductENSG00000109062 (Ensembl)
NUDT17GeneProductENSG00000186364 (Ensembl)
Nonsense mediated decay pathwayPathway
PDZK1GeneProductENSG00000174827 (Ensembl)
PDZK1IP1GeneProductENSG00000162366 (Ensembl)
PEX11BGeneProductENSG00000131779 (Ensembl)
PI3KMetaboliteCHEBI:89296 (ChEBI)
PIAS3GeneProductENSG00000131788 (Ensembl)
POLR3CGeneProductENSG00000186141 (Ensembl)
POLR3FGeneProductENSG00000132664 (Ensembl)
POLR3GGeneProductENSG00000113356 (Ensembl)
POLR3GLGeneProductENSG00000121851 (Ensembl)
PYM1GeneProductENSG00000170473 (Ensembl)
Peroxisomal proliferationPathway
Peroxisome divisionPathway
Production of anti-microbial proteins and inflammatory cytokinesPathway
Proteasomal degradation of DDIT4Pathway
RABL3GeneProductENSG00000144840 (Ensembl)
RBM8AGeneProductENSG00000131795 (Ensembl)
RIG-I pathwayPathway
RNARna
RNF115GeneProductENSG00000121848 (Ensembl)
SCARB1GeneProductENSG00000073060 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SLC26A6GeneProductENSG00000225697 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
SUMO1GeneProductENSG00000116030 (Ensembl)
Signalling pathwaysPathway
Steroid hormone signalling pathwayPathway
SubstrateMetabolite
TBPMetaboliteCHEBI:35019 (ChEBI)
TCR signallingPathway
TNFRSF14GeneProductENSG00000157873 (Ensembl)
TXNGeneProductENSG00000136810 (Ensembl)
TXNIPGeneProductENSG00000117289 (Ensembl)
Tumour cell growthPathway
UBE2IGeneProductENSG00000103275 (Ensembl)
Viral peptideMetabolite
ZFHX3GeneProductENSG00000140836 (Ensembl)
mTORC1ProteinF5H479 (Uniprot-TrEMBL)
non-self RNARna
non-self dsDNAGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5362"
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