Warburg effect modulated by deubiquitinating enzymes and their substrates (Homo sapiens)

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3OTUD6BOTUB2HIF-1αUSP19HIF-1αPyruvatePEPVEGFOTUD6B3PGU2AF2HK2MTORGlucoseLactateUSP19USP28LDHA1,3-BPGFBP1OTUB2USP7G6PGLUT1OTUB2USP7VHLFOXO1PGK1OTUD7BPGAM1G6PCUSP44OTUB2GA3POTUB2PI3KPyruvateF1,6BPUSP19AKT1c-MycOTUB2SIRT7142GlucoseF6P2PGFOXO1USP7USP37USP37OTUB2OTUB2OTUD7BOTUD6BUSP19


Description

Schematic model for the Warburg effect modulated by deubiquitinating enzymes (DUBs) and their substrates. The black arrow indicates direct stimulatory/inhibitory modification, and the blue arrow indicates transcriptional stimulatory modification.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Behrman EJ, Gopalan V; ''Phosphoenolpyruvate: An end to hand-waving.''; Biochem Mol Biol Educ, 2008 PubMed Europe PMC Scholia
  2. Arafeh R, Samuels Y; ''PIK3CA in cancer: The past 30 years.''; Semin Cancer Biol, 2019 PubMed Europe PMC Scholia
  3. So-Hee Kim: Kwang-hyun Baek; ''Regulation of Cancer Metabolism by Deubiquitinating Enzymes: The Warburg Effect''; https://doi.org/10.3390/IJMS22126173, 2021 DOI Scholia
  4. Claesson-Welsh L, Welsh M; ''VEGFA and tumour angiogenesis.''; J Intern Med, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126981view12:23, 12 July 2023Marlen madded VEGFR2 and state (Ac)
126980view11:47, 12 July 2023Marlen mModified description
126978view19:06, 11 July 2023Marlen madded modification of PGK1
126977view18:34, 11 July 2023Marlen mModified description
126971view19:11, 10 July 2023Marlen mModified description
126968view09:07, 9 July 2023Marlen madded missing connections and steps in pathway
126965view20:06, 8 July 2023EgonwFixed a typo
126964view19:11, 8 July 2023EgonwCorrect data source
126963view10:12, 8 July 2023Marlen mcorrected PEG to PEP and added missing database references
126962view08:38, 8 July 2023Marlen mAdded database reference for gene products
126945view13:13, 7 July 2023Marlen mremoved unconnected interaction between 2PG and PEP
126903view17:26, 30 June 2023Marlen mReverted to version '13:54, 30. Jun. 2023' by Marlen m
126902view17:24, 30 June 2023Marlen mReverted to version '14:11, 29. Dez. 2022' by Marlen m
126900view13:54, 30 June 2023Marlen mfixed connection between USP44 and FBP1
124891view14:11, 29 December 2022EgonwModified title
124890view14:07, 29 December 2022EgonwManually added the DOI identifier as identifier too
122594view10:30, 20 April 2022EweitzModified description
122593view10:29, 20 April 2022EweitzModified title
122336view22:21, 19 March 2022Andramain reference
122335view22:17, 19 March 2022AndraOntology Term : 'cancer' added !
122334view22:17, 19 March 2022AndraOntology Term : 'glycolysis pathway' added !
122333view22:16, 19 March 2022AndraModified description
122332view22:13, 19 March 2022AndraNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,3-BPGMetabolite89363 (ChEBI)
2PGMetabolite24344 (ChEBI)
3PGMetabolite17050 (ChEBI)
AKT1GeneProduct207 (Entrez Gene)
F1,6BPMetabolite32966 (ChEBI)
F6PMetabolite61527 (ChEBI)
FBP1GeneProductFBP1 (HGNC)
FOXO1GeneProduct2308 (Entrez Gene)
G6PMetabolite4170 (ChEBI)
G6PCGeneProduct2538 (Entrez Gene)
GA3PMetabolite17138 (ChEBI)
GLUT1GeneProductENSG00000117394 (Ensembl)
GlucoseMetabolite4167 (ChEBI)
HIF-1αGeneProduct3091 (Entrez Gene)
HK2GeneProductENSG00000159399 (Ensembl)
LDHAGeneProduct3939 (Entrez Gene)
LactateMetabolite24996 (ChEBI)
MTORGeneProduct2475 (Entrez Gene)
OTUB2GeneProduct78990 (Entrez Gene)
OTUD6BGeneProduct51633 (Entrez Gene)
OTUD7BGeneProduct56957 (Entrez Gene)
PEPMetabolite18021 (ChEBI)
PGAM1GeneProduct5223 (Entrez Gene)
PGK1GeneProduct5230 (Entrez Gene)
PI3KGeneProductENSG00000121879 (Ensembl)
PyruvateMetabolite15361 (ChEBI)
SIRT7GeneProduct51547 (Entrez Gene)
U2AF2GeneProduct11338 (Entrez Gene)
USP19GeneProduct10869 (Entrez Gene)
USP28GeneProduct57646 (Entrez Gene)
USP37GeneProduct57695 (Entrez Gene)
USP44GeneProduct84101 (Entrez Gene)
USP7GeneProduct7874 (Entrez Gene)
VEGFGeneProductENSG00000112715 (Ensembl)
VHLGeneProductENSG00000134086 (Ensembl)
c-MycGeneProductENSG00000136997 (Ensembl)

Annotated Interactions

No annotated interactions

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