8p23.1 copy number variation syndrome (Homo sapiens)

From WikiPathways

Revision as of 07:54, 3 August 2023 by Fehrhart (Talk | contribs)
Jump to: navigation, search
3333171922437228452316720933312224271016392240611373163413183941281138153040121521384133141540333044343628134029912737261025Testicular developmentTumor invasion and metastasisB-lymphocyte development, differentiation and signalingSolubilization of cross-linked TGVesicle trafickingAutophagyInvolved in histone regulationCardiac-super-enhancersCardiomyocyte gene expressionPhosphorylated phosphatidylinositolsM1 macrophage polarisationUnknown functionCardiac myocyte enlargementPhosphorylation of CGASTransmitting signals through surface immunoglobulinsSupports the pro-B to pre-B transitionSignaling for growth arrest and apoptosis downstream of B-cell receptorProbably nvolved inglycogen breakdownDNA damage-induced apoptosisEndocardial / endothelial gene expressionCardiac specific gene expressionTelomere shorteningIntracellular degradation and turnover of proteinsTight junctionMyotubularin-related phosphatasesdifferentiation of photo-receptor cellsPre-BCR-mediated NF-kappa-B activation Cardiac development and functionLate stage macropinocytosisPrometaphaseSpindle pole assemblyTelomeresInvolved in base excision repair of damaged DNAthrough oxidation or binding mutagenic agentsInsulin secretion2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNAXAV939H+CD79ANKX6-1FYNp38 MAPK signaling pathwayC8orf74L-methionyl-[protein]SqualeneNUMA1Proteasome degradationL-methionyl-(S)-S-oxide-[protein]Sphingosine-1-phosphateSOX7CTSBMTMR9Sphingosine-1-phosphate lyaseDEFB136FDFT1BTKMCRS1TERF1H+MSRAPRSS51TLR4O-phospho-L-tyrosyl-[protein]HEPACAM2TalazoparibERI1MTMR8L-tyrosyl-[protein]TERTAP-1H+Mg2+[thioredoxin]-disulfideBeta-catenin independent WNT signalingMTMR7LYNMEPEADP2 diphosphateGATA4RAF1CLDN23CTNNB1MAPK12 (2E,6E)-farnesyl diphosphateRP1L13'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNASLBPBMPXKR6FAM167ABLKPRSS55HSPD15'-end 5'-monophospho-2'-deoxyribonucleoside-DNAWNT signaling[thioredoxin]-dithiolANFNAD+NADPHNADP+RNAPDX1AXIN1SLC2A4H2OTLR2MTMR6ATPSLC35G5C8orf12nicotinamide4-O-(ADP-D-ribosyl)-L-aspartyl residueCD79BC8orf49TERF1PPP1R3BMFHAS1MAPK3BMPRENEIL2TNKSTBX5PINX1L-aspartylDEFB135DEFB134Unknown functionUnknown functionUnknown function


Description

Pathway of relevant genes on the chromosome 8p23.1 duplication / deletion syndrome

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Yoo JE, Oh BK, Park YN; ''Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres.''; J Mol Biol, 2009 PubMed Europe PMC Scholia
  2. Wang HH, Sun PF, Chen WK, Zhong J, Shi QQ, Weng ML, Ma D, Miao CH; ''High Glucose Stimulates Expression of MFHAS1 to Mitigate Inflammation via Akt/HO-1 Pathway in Human Umbilical Vein Endothelial Cells.''; Inflammation, 2018 PubMed Europe PMC Scholia
  3. Cook BD, Dynek JN, Chang W, Shostak G, Smith S; ''Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia
  4. Mochizuki Y, Majerus PW; ''Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
  5. Yang YQ, Gharibeh L, Li RG, Xin YF, Wang J, Liu ZM, Qiu XB, Xu YJ, Xu L, Qu XK, Liu X, Fang WY, Huang RT, Xue S, Nemer G; ''GATA4 loss-of-function mutations underlie familial tetralogy of fallot.''; Hum Mutat, 2013 PubMed Europe PMC Scholia
  6. Bowne SJ, Daiger SP, Malone KA, Heckenlively JR, Kennan A, Humphries P, Hughbanks-Wheaton D, Birch DG, Liu Q, Pierce EA, Zuo J, Huang Q, Donovan DD, Sullivan LS; ''Characterization of RP1L1, a highly polymorphic paralog of the retinitis pigmentosa 1 (RP1) gene.''; Mol Vis, 2003 PubMed Europe PMC Scholia
  7. Guo R, Rowe PS, Liu S, Simpson LG, Xiao ZS, Quarles LD; ''Inhibition of MEPE cleavage by Phex.''; Biochem Biophys Res Commun, 2002 PubMed Europe PMC Scholia
  8. Banik SS, Counter CM; ''Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  9. Liu H, Diao H, Hou J, Yu H, Wen H; ''Soluble expression and purification of human β-defensin DEFB136 in Escherichia coli and identification of its bioactivity.''; Protein Expr Purif, 2021 PubMed Europe PMC Scholia
  10. Guo L, Zhong D, Lau S, Liu X, Dong XY, Sun X, Yang VW, Vertino PM, Moreno CS, Varma V, Dong JT, Zhou W; ''Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.''; Mol Cancer Res, 2008 PubMed Europe PMC Scholia
  11. Dihanich S, Civiero L, Manzoni C, Mamais A, Bandopadhyay R, Greggio E, Lewis PA; ''GTP binding controls complex formation by the human ROCO protein MASL1.''; FEBS J, 2014 PubMed Europe PMC Scholia
  12. Oskouian B, Mendel J, Shocron E, Lee MA Jr, Fyrst H, Saba JD; ''Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  13. Tretter T, Ross AE, Dordai DI, Desiderio S; ''Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk.''; J Exp Med, 2003 PubMed Europe PMC Scholia
  14. Ritonja A, Popovic T, Turk V, Wiedenmann K, Machleidt W; ''Amino acid sequence of human liver cathepsin B.''; FEBS Lett, 1985 PubMed Europe PMC Scholia
  15. Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A; ''Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  16. Yuan K, Li N, Jiang K, Zhu T, Huo Y, Wang C, Lu J, Shaw A, Thomas K, Zhang J, Mann D, Liao J, Jin C, Yao X; ''PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  17. Song H, Li Y, Chen G, Xing Z, Zhao J, Yokoyama KK, Li T, Zhao M; ''Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.''; Biochem Biophys Res Commun, 2004 PubMed Europe PMC Scholia
  18. Zhong J, Wang H, Chen W, Sun Z, Chen J, Xu Y, Weng M, Shi Q, Ma D, Miao C; ''Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways.''; Cell Death Dis, 2017 PubMed Europe PMC Scholia
  19. Chang W, Dynek JN, Smith S; ''NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.''; Biochem J, 2005 PubMed Europe PMC Scholia
  20. Ang YS, Rivas RN, Ribeiro AJS, Srivas R, Rivera J, Stone NR, Pratt K, Mohamed TMA, Fu JD, Spencer CI, Tippens ND, Li M, Narasimha A, Radzinsky E, Moon-Grady AJ, Yu H, Pruitt BL, Snyder MP, Srivastava D; ''Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis.''; Cell, 2016 PubMed Europe PMC Scholia
  21. Kumkhaek C, Aerbajinai W, Liu W, Zhu J, Uchida N, Kurlander R, Hsieh MM, Tisdale JF, Rodgers GP; ''MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway.''; Blood, 2013 PubMed Europe PMC Scholia
  22. Shi Q, Xiong B, Zhong J, Wang H, Ma D, Miao C; ''MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.''; Mol Immunol, 2017 PubMed Europe PMC Scholia
  23. Lee Y, Shioi T, Kasahara H, Jobe SM, Wiese RJ, Markham BE, Izumo S; ''The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression.''; Mol Cell Biol, 1998 PubMed Europe PMC Scholia
  24. Zhong J, Shi QQ, Zhu MM, Shen J, Wang HH, Ma D, Miao CH; ''MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-κB Signaling Pathway Following Negative Regulation.''; PLoS One, 2015 PubMed Europe PMC Scholia
  25. van der Stappen JW, Williams AC, Maciewicz RA, Paraskeva C; ''Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D.''; Int J Cancer, 1996 PubMed Europe PMC Scholia
  26. Lee KH, Evans S, Ruan TY, Lassar AB; ''SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer.''; Development, 2004 PubMed Europe PMC Scholia
  27. Lourenço D, Brauner R, Rybczynska M, Nihoul-Fékété C, McElreavey K, Bashamboo A; ''Loss-of-function mutation in GATA4 causes anomalies of human testicular development.''; Proc Natl Acad Sci U S A, 2011 PubMed Europe PMC Scholia
  28. Tanaka H, Katoh H, Negishi M; ''Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  29. Mai J, Finley RL Jr, Waisman DM, Sloane BF; ''Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  30. Zou J, Zhang C, Marjanovic J, Kisseleva MV, Majerus PW, Wilson MP; ''Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia
  31. Zou J, Chang SC, Marjanovic J, Majerus PW; ''MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  32. Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F; ''Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.''; Nature, 2009 PubMed Europe PMC Scholia
  33. Dymecki SM, Niederhuber JE, Desiderio SV; ''Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.''; Science, 1990 PubMed Europe PMC Scholia
  34. Senda Y, Murata-Kamiya N, Hatakeyama M; ''C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility.''; Cancer Sci, 2016 PubMed Europe PMC Scholia
  35. Ozaki Y, Matsui H, Asou H, Nagamachi A, Aki D, Honda H, Yasunaga S, Takihara Y, Yamamoto T, Izumi S, Ohsugi M, Inaba T; ''Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation.''; Mol Cell, 2012 PubMed Europe PMC Scholia
  36. Sunagawa Y, Morimoto T, Takaya T, Kaichi S, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K; ''Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  37. Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SHE, Chen C, Mao Z, Ge B; ''Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.''; Nature, 2018 PubMed Europe PMC Scholia
  38. Weaver KL, Alves-Guerra MC, Jin K, Wang Z, Han X, Ranganathan P, Zhu X, DaSilva T, Liu W, Ratti F, Demarest RM, Tzimas C, Rice M, Vasquez-Del Carpio R, Dahmane N, Robbins DJ, Capobianco AJ; ''NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.''; Cancer Res, 2014 PubMed Europe PMC Scholia
  39. Maekawa M, Terasaka S, Mochizuki Y, Kawai K, Ikeda Y, Araki N, Skolnik EY, Taguchi T, Arai H; ''Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.''; Proc Natl Acad Sci U S A, 2014 PubMed Europe PMC Scholia
  40. Dominski Z, Yang XC, Kaygun H, Dadlez M, Marzluff WF; ''A 3' exonuclease that specifically interacts with the 3' end of histone mRNA.''; Mol Cell, 2003 PubMed Europe PMC Scholia
  41. Yau JL, Rasmuson S, Andrew R, Graham M, Noble J, Olsson T, Fuchs E, Lathe R, Seckl JR; ''Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease.''; Neuroscience, 2003 PubMed Europe PMC Scholia
  42. Pandit J, Danley DE, Schulte GK, Mazzalupo S, Pauly TA, Hayward CM, Hamanaka ES, Thompson JF, Harwood HJ Jr; ''Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  43. Cho-Park PF, Steller H; ''Proteasome regulation by ADP-ribosylation.''; Cell, 2013 PubMed Europe PMC Scholia
  44. Zhang B, Bai YX, Ma HH, Feng F, Jin R, Wang ZL, Lin J, Sun SP, Yang P, Wang XX, Huang PT, Huang CF, Peng Y, Chen YC, Kung HF, Huang JJ; ''Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  45. Friedrichs B, Tepel C, Reinheckel T, Deussing J, von Figura K, Herzog V, Peters C, Saftig P, Brix K; ''Thyroid functions of mouse cathepsins B, K, and L.''; J Clin Invest, 2003 PubMed Europe PMC Scholia
  46. Estrada S, Nycander M, Hill NJ, Craven CJ, Waltho JP, Björk I; ''The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin L.''; Biochemistry, 1998 PubMed Europe PMC Scholia
  47. Chi NW, Lodish HF; ''Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  48. Song Z; ''Roles of the nucleotide sugar transporters (SLC35 family) in health and disease.''; Mol Aspects Med, 2013 PubMed Europe PMC Scholia
  49. Ryan K, Bolaňos B, Smith M, Palde PB, Cuenca PD, VanArsdale TL, Niessen S, Zhang L, Behenna D, Ornelas MA, Tran KT, Kaiser S, Lum L, Stewart A, Gajiwala KS; ''Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.''; J Biol Chem, 2021 PubMed Europe PMC Scholia
  50. Lecointre C, Simon V, Kerneur C, Allemand F, Fournet A, Montarras I, Pons JL, Gelin M, Brignatz C, Urbach S, Labesse G, Roche S; ''Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation.''; Structure, 2018 PubMed Europe PMC Scholia
  51. Bewarder N, Weinrich V, Budde P, Hartmann D, Flaswinkel H, Reth M, Frey J; ''In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.''; Mol Cell Biol, 1996 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134457view00:15, 22 July 2024EweitzFix typo, standardize case
134456view00:14, 22 July 2024EweitzOntology Term : 'congenital diaphragmatic hernia' added !
127110view13:39, 3 August 2023Fehrhartcorrection in progress
127109view13:33, 3 August 2023FehrhartModified description
127108view13:32, 3 August 2023FehrhartOntology Term : 'chromosomal deletion syndrome' added !
127107view13:30, 3 August 2023Fehrhartcorrection in progress
127106view08:59, 3 August 2023Fehrhartcorrection in progress
127105view07:54, 3 August 2023Fehrhartcorrection in progress
127104view16:07, 2 August 2023Fehrhartcorrection in progress
127103view15:03, 2 August 2023Fehrhartcorrections in progress
126453view19:54, 30 April 2023AlexanderPicoOntology Term : 'disease pathway' added !
126452view19:54, 30 April 2023AlexanderPicoOntology Term : 'chromosomal duplication syndrome' added !
126042view12:46, 29 March 2023FehrhartModified title
126000view21:11, 24 March 2023EgonwMade three pathways clickable
125998view21:08, 24 March 2023EgonwUse Ensembl
125937view17:27, 22 March 2023RensEikelboomModified title
125936view17:25, 22 March 2023RensEikelboomNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2 (2E,6E)-farnesyl diphosphateMetabolite
2 diphosphateMetabolite
2'-deoxyribonucleotide-(2'-

deoxyribose 5'-phosphate)-

2'-deoxyribonucleotide-DNA		Metabolite
3'-end 2'-deoxyribonucleotide-

(2,3-dehydro-2,3-deoxyribose

5'-phosphate)-DNA		Metabolite
4-O-(ADP-D-ribosyl)-L-aspartyl residueMetaboliteCHEBI:138102 (ChEBI)
5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNAMetabolite
ADPMetabolite
ANFGeneProduct
AP-1GeneProduct
ATPMetabolite
AXIN1GeneProductENSG00000103126 (Ensembl)
BLKGeneProductENSG00000136573 (Ensembl)
BMPProtein
BMPREGeneProduct
BTKGeneProductENSG00000010671 (Ensembl)
Beta-catenin independent WNT signalingPathwayWP3558 (WikiPathways)
C8orf12GeneProductENSG00000184608 (Ensembl)
C8orf49GeneProductENSG00000255394 (Ensembl)
C8orf74GeneProductENSG00000171060 (Ensembl)
CD79AGeneProduct
CD79BGeneProduct
CLDN23GeneProductENSG00000253958 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTSBGeneProductENSG00000164733 (Ensembl)
DEFB134GeneProductENSG00000205882 (Ensembl)
DEFB135GeneProductENSG00000205883 (Ensembl)
DEFB136GeneProductENSG00000205884 (Ensembl)
ERI1GeneProductENSG00000104626 (Ensembl)
FAM167AGeneProductENSG00000154319 (Ensembl)
FDFT1GeneProductENSG00000079459 (Ensembl)
FYNGeneProductENSG00000010810 (Ensembl)
GATA4GeneProductENSG00000136574 (Ensembl)
H+Metabolite
H2OMetabolite15377 (ChEBI)
HEPACAM2GeneProductENSG00000188175 (Ensembl)
HSPD1GeneProductENSG00000144381 (Ensembl)
L-aspartylMetaboliteCHEBI:29958 (ChEBI)
L-methionyl-(S)-S-oxide-[protein]Metabolite29950 (ChEBI)
L-methionyl-[protein]Metabolite16044 (ChEBI)
L-tyrosyl-[protein]Metabolite
LYNGeneProductENSG00000254087 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MCRS1GeneProductENSG00000187778 (Ensembl)
MEPEGeneProductENSG00000152595 (Ensembl)
MFHAS1GeneProductENSG00000147324 (Ensembl)
MSRAGeneProductENSG00000175806 (Ensembl)
MTMR6GeneProductENSG00000139505 (Ensembl)
MTMR7GeneProductENSG00000003987 (Ensembl)
MTMR8GeneProductENSG00000102043 (Ensembl)
MTMR9GeneProductENSG00000104643 (Ensembl)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NAD+MetaboliteCHEBI:15846 (ChEBI)
NADP+Metabolite
NADPHMetabolite
NEIL2GeneProductENSG00000154328 (Ensembl)
NKX6-1GeneProductENSG00000163623 (Ensembl)
NUMA1GeneProductENSG00000137497 (Ensembl)
O-phospho-L-tyrosyl-[protein]Metabolite
PDX1GeneProductENSG00000139515 (Ensembl)
PINX1GeneProductENSG00000258724 (Ensembl)
PPP1R3BGeneProductENSG00000173281 (Ensembl)
PRSS51GeneProductENSG00000253649 (Ensembl)
PRSS55GeneProductENSG00000184647 (Ensembl)
Proteasome degradationPathwayWP183 (WikiPathways)
RAF1GeneProductENSG00000132155 (Ensembl)
RNAMetaboliteCHEBI:33697 (ChEBI)
RP1L1GeneProductENSG00000183638 (Ensembl)
SLBPGeneProductENSG00000163950 (Ensembl)
SLC2A4GeneProductENSG00000181856 (Ensembl)
SLC35G5GeneProductENSG00000177710 (Ensembl)
SOX7GeneProductENSG00000171056 (Ensembl)
Sphingosine-1-phosphateProtein
Sphingosine-1-phosphate lyaseProtein
SqualeneMetabolite
TBX5GeneProductENSG00000089225 (Ensembl)
TERF1GeneProductENSG00000147601 (Ensembl)
TERTGeneProductENSG00000164362 (Ensembl)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TNKSGeneProductENSG00000173273 (Ensembl)
TalazoparibMetabolite3137320 (ChEMBL compound)
WNT signalingPathwayWP428 (WikiPathways)
XAV939MetaboliteQ27132250 (Wikidata)
XKR6GeneProductENSG00000171044 (Ensembl)
[thioredoxin]-disulfideMetabolite50058 (ChEBI)
[thioredoxin]-dithiolMetabolite44120 (ChEBI)
nicotinamideMetaboliteCHEBI:17154 (ChEBI)
p38 MAPK signaling pathwayPathwayWP400 (WikiPathways)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
MSRAmim-catalysis14217 (Rhea) https://www.uniprot.org/uniprotkb/Q9UJ68/entry
mim-conversion14217 (Rhea)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5346"
Personal tools