Cell lineage map for neuronal differentiation (Rattus norvegicus)

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Stem CellMsx1Slc18a3Hes3Slc6a4NgfrGlra1Foxa2NodalOlig2Tpm1Lef1AcheZfp42Gata6Lhx1ThTbr1Lin7aEvx1Cd34LOC683282Ap2a1Cdh1Cldn11EsrrbDppa3l1Slc1a3GlsDlg1SypDll1Adra2bGata4Map2NeflGabbr1Slc1a2Slc6a1Pax3Glra2Rimbp2Unc13aFoxa2Pou5f1Fgf4Snap25Erc1Slc6a5Gad2TbxtTph1Gabbr2Tubb3FevBsnGphnErasNesCnpTwist2Slc17a6Snai1Grin1Hes5GfapDcxNefmGlra3MogSlc6a2Hes1S100bAdra2cItga6ChatShank1Mixl1Homer2Krt15Sox10Ppfia1Htr5aNlgn1Dlg3Dlg4Robo1Nr4a2GlrbCaskTncFut4Pecam1Msx2Kcnj6Grin2bTwist1Sox17Foxd3Rbfox3Fabp7GlulPcloCd24Itgb1Htr1aSlc17a7Slc6a3MbpCdh2Bmp4Hnf4aSox2Dlg2Snai2Adra2aNanogPax6Shank3Fbxo15Ap2a2Homer3Lmx1bSlc6a9Gad1Klf4Glra4Notch1Sox9Aqp4Rims2Cacng2Cspg4Homer1Aldh1l1EctodermMesodermEndodermNeural progenitorNon-neural ectodermNeural crestImmature neuronAstrocyteOligodendrocyteMature neuronPre-synapsePost-synapseGlutamatergicGABAergicGlycinergicCholinergicDopaminergicNoradrenergicSerotonergic


Description

This cell lineage map consists of a set of cell types emerging during neural differentiation. A selection of cell type-specific markers was made based on literature (e.g. Beccari et al., 2018, https://doi.org/10.1038/s41586-018-0578-0; Kügler et al., 2010, https://doi.org/10.14573/altex.2010.1.16; Spangler et al., 2018, https://doi.org/10.1016/j.scr.2018.07.022; Tao and Zhang, 2016, https://doi.org/10.1016/j.stem.2016.10.015) to distinguish these different cell types. This map was published in: Victoria de Leeuw et al., 2020, NeuroToxicology 76, 1-9. https://doi.org/10.1016/j.neuro.2019.09.014.

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Bibliography

  1. ''Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids''; , DOI Scholia
  2. ''Markers of murine embryonic and neural stem cells, neurons and astrocytes: Reference points for developmental neurotoxicity testing ''; , DOI Scholia
  3. ''A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo''; , DOI Scholia
  4. ''Neural Subtype Specification from Human Pluripotent Stem Cells''; , DOI Scholia
  5. ''Differential effects of fluoxetine and venlafaxine in the neural embryonic stem cell test (ESTn) revealed by a cell lineage map''; , DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
127428view10:16, 1 October 2023EgonwAdded the DOIs as literature references
127424view09:55, 1 October 2023EgonwOntology Term : 'regulatory pathway' added !
127423view09:55, 1 October 2023EgonwOntology Term : 'neuron' added !
127322view08:53, 14 September 2023PenningsModified description
127320view08:49, 14 September 2023PenningsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcheGeneProductENSRNOG00000050841 (Ensembl)
Adra2aGeneProductENSRNOG00000047545 (Ensembl)
Adra2bGeneProductENSRNOG00000013887 (Ensembl)
Adra2cGeneProductENSRNOG00000009299 (Ensembl)
Aldh1l1GeneProductENSRNOG00000047023 (Ensembl)
Ap2a1GeneProductENSRNOG00000026243 (Ensembl)
Ap2a2GeneProductENSRNOG00000019534 (Ensembl)
Aqp4GeneProductENSRNOG00000016043 (Ensembl)
Bmp4GeneProductENSRNOG00000009694 (Ensembl)
BsnGeneProductENSRNOG00000030714 (Ensembl)
Cacng2GeneProductENSRNOG00000006226 (Ensembl)
CaskGeneProductENSRNOG00000060946 (Ensembl)
Cd24GeneProductENSRNOG00000000321 (Ensembl)
Cd34GeneProductENSRNOG00000045558 (Ensembl)
Cdh1GeneProductENSRNOG00000020151 (Ensembl)
Cdh2GeneProductENSRNOG00000015602 (Ensembl)
ChatGeneProductENSRNOG00000025012 (Ensembl)
Cldn11GeneProductENSRNOG00000010263 (Ensembl)
CnpGeneProductENSRNOG00000017496 (Ensembl)
Cspg4GeneProductENSRNOG00000017208 (Ensembl)
DcxGeneProductENSRNOG00000047712 (Ensembl)
Dlg1GeneProductENSRNOG00000038597 (Ensembl)
Dlg2GeneProductENSRNOG00000022635 (Ensembl)
Dlg3GeneProductENSRNOG00000002767 (Ensembl)
Dlg4GeneProductENSRNOG00000018526 (Ensembl)
Dll1GeneProductENSRNOG00000059984 (Ensembl)
Dppa3l1GeneProductENSRNOG00000022376 (Ensembl)
ErasGeneProductENSRNOG00000048396 (Ensembl)
Erc1GeneProductENSRNOG00000009264 (Ensembl)
EsrrbGeneProductENSRNOG00000010259 (Ensembl)
Evx1GeneProductENSRNOG00000053106 (Ensembl)
Fabp7GeneProductENSRNOG00000000814 (Ensembl)
Fbxo15GeneProductENSRNOG00000038225 (Ensembl)
FevGeneProductENSRNOG00000017856 (Ensembl)
Fgf4GeneProductENSRNOG00000020890 (Ensembl)
Foxa2GeneProductENSRNOG00000013133 (Ensembl)
Foxd3GeneProductENSRNOGxxxxx (Ensembl)
Fut4GeneProductENSRNOG00000009157 (Ensembl)
Gabbr1GeneProductENSRNOG00000000774 (Ensembl)
Gabbr2GeneProductENSRNOG00000008431 (Ensembl)
Gad1GeneProductENSRNOG00000000007 (Ensembl)
Gad2GeneProductENSRNOG00000018200 (Ensembl)
Gata4GeneProductENSRNOG00000010708 (Ensembl)
Gata6GeneProductENSRNOG00000023433 (Ensembl)
GfapGeneProductENSRNOG00000002919 (Ensembl)
Glra1GeneProductENSRNOG00000013588 (Ensembl)
Glra2GeneProductENSRNOG00000003313 (Ensembl)
Glra3GeneProductENSRNOG00000049792 (Ensembl)
Glra4GeneProductENSRNOG00000002391 (Ensembl)
GlrbGeneProductENSRNOG00000010199 (Ensembl)
GlsGeneProductENSRNOG00000056246 (Ensembl)
GlulGeneProductENSRNOG00000049560 (Ensembl)
GphnGeneProductENSRNOG00000028366 (Ensembl)
Grin1GeneProductENSRNOG00000011726 (Ensembl)
Grin2bGeneProductENSRNOG00000008766 (Ensembl)
Hes1GeneProductENSRNOG00000001720 (Ensembl)
Hes3GeneProductENSRNOG00000010893 (Ensembl)
Hes5GeneProductENSRNOG00000013850 (Ensembl)
Hnf4aGeneProductENSRNOG00000008895 (Ensembl)
Homer1GeneProductENSRNOG00000047014 (Ensembl)
Homer2GeneProductENSRNOG00000061450 (Ensembl)
Homer3GeneProductENSRNOG00000020229 (Ensembl)
Htr1aGeneProductENSRNOG00000010254 (Ensembl)
Htr5aGeneProductENSRNOG00000007066 (Ensembl)
Itga6GeneProductENSRNOG00000001518 (Ensembl)
Itgb1GeneProductENSRNOG00000010966 (Ensembl)
Kcnj6GeneProductENSRNOG00000001658 (Ensembl)
Klf4GeneProductENSRNOG00000016299 (Ensembl)
Krt15GeneProductENSRNOG00000014099 (Ensembl)
LOC683282GeneProductENSRNOGxxxxx (Ensembl)
Lef1GeneProductENSRNOG00000010121 (Ensembl)
Lhx1GeneProductENSRNOG00000002812 (Ensembl)
Lin7aGeneProductENSRNOG00000004527 (Ensembl)
Lmx1bGeneProductENSRNOG00000017019 (Ensembl)
Map2GeneProductENSRNOG00000011841 (Ensembl)
MbpGeneProductENSRNOG00000016516 (Ensembl)
Mixl1GeneProductENSRNOG00000048085 (Ensembl)
MogGeneProductENSRNOG00000000775 (Ensembl)
Msx1GeneProductENSRNOG00000006876 (Ensembl)
Msx2GeneProductENSRNOG00000018355 (Ensembl)
NanogGeneProductENSRNOG00000008368 (Ensembl)
NeflGeneProductENSRNOG00000013658 (Ensembl)
NefmGeneProductENSRNOG00000013916 (Ensembl)
NesGeneProductENSRNOG00000018681 (Ensembl)
NgfrGeneProductENSRNOG00000005392 (Ensembl)
Nlgn1GeneProductENSRNOG00000032576 (Ensembl)
NodalGeneProductENSRNOG00000000556 (Ensembl)
Notch1GeneProductENSRNOG00000019322 (Ensembl)
Nr4a2GeneProductENSRNOG00000005600 (Ensembl)
Olig2GeneProductENSRNOG00000028658 (Ensembl)
Pax3GeneProductENSRNOG00000013670 (Ensembl)
Pax6GeneProductENSRNOG00000004410 (Ensembl)
PcloGeneProductENSRNOG00000005726 (Ensembl)
Pecam1GeneProductENSRNOGxxxxx (Ensembl)
Pou5f1GeneProductENSRNOG00000046487 (Ensembl)
Ppfia1GeneProductENSRNOG00000020857 (Ensembl)
Rbfox3GeneProductENSRNOG00000003386 (Ensembl)
Rimbp2GeneProductENSRNOG00000022893 (Ensembl)
Rims2GeneProductENSRNOG00000004201 (Ensembl)
Robo1GeneProductENSRNOG00000029614 (Ensembl)
S100bGeneProductENSRNOG00000001295 (Ensembl)
Shank1GeneProductENSRNOG00000019207 (Ensembl)
Shank3GeneProductENSRNOG00000052296 (Ensembl)
Slc17a6GeneProductENSRNOG00000016147 (Ensembl)
Slc17a7GeneProductENSRNOG00000020650 (Ensembl)
Slc18a3GeneProductENSRNOG00000062141 (Ensembl)
Slc1a2GeneProductENSRNOG00000005479 (Ensembl)
Slc1a3GeneProductENSRNOG00000016163 (Ensembl)
Slc6a1GeneProductENSRNOG00000006527 (Ensembl)
Slc6a2GeneProductENSRNOG00000016311 (Ensembl)
Slc6a3GeneProductENSRNOG00000017302 (Ensembl)
Slc6a4GeneProductENSRNOG00000003476 (Ensembl)
Slc6a5GeneProductENSRNOG00000031662 (Ensembl)
Slc6a9GeneProductENSRNOG00000019484 (Ensembl)
Snai1GeneProductENSRNOG00000009594 (Ensembl)
Snai2GeneProductENSRNOG00000047699 (Ensembl)
Snap25GeneProductENSRNOG00000006037 (Ensembl)
Sox10GeneProductENSRNOG00000011305 (Ensembl)
Sox17GeneProductENSRNOG00000027357 (Ensembl)
Sox2GeneProductENSRNOG00000012199 (Ensembl)
Sox9GeneProductENSRNOG00000002607 (Ensembl)
SypGeneProductENSRNOG00000059720 (Ensembl)
Tbr1GeneProductENSRNOG00000005049 (Ensembl)
TbxtGeneProductENSRNOG00000012229 (Ensembl)
ThGeneProductENSRNOG00000020410 (Ensembl)
TncGeneProductENSRNOG00000058645 (Ensembl)
Tph1GeneProductENSRNOG00000011672 (Ensembl)
Tpm1GeneProductENSRNOG00000018184 (Ensembl)
Tubb3GeneProductENSRNOG00000017209 (Ensembl)
Twist1GeneProductENSRNOG00000011101 (Ensembl)
Twist2GeneProductENSRNOG00000020355 (Ensembl)
Unc13aGeneProductENSRNOG00000018452 (Ensembl)
Zfp42GeneProductENSRNOGxxxxx (Ensembl)

Annotated Interactions

No annotated interactions

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