Hepatitis B infection (Homo sapiens)

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Innate immune response evasion1-3HepatocyteLegendEndosomeHBVMitochondriaEndosomeNucelusControl of cell growth,apoptosis and senescensepgRNAViral RNAHepatocyte differentiationcccDNAMHBsReverse transcription,partial synthesis of + strandSurvival factors,growth factors,cytokinesHBx stabilityRelief of HBx stabilityand viral replicationHCC invasion and metastasisTumor suppressivepathwayProteasomeER stressJAK1HSPG2MMP9NFATC1EGR2CDKN1AATF2TGFB1MAP2K3ATP6AP1FASLGMAP3K1Ca2+MYD88ESCRT PathwayARAFMAPK11TNFDNA Damage ResponseDDB1CREB3SLC10A1LHBsSHBsMHBsLHBsSHBsHBcAgHBeAgPHBxTGFB2TGFB3TGFBR1TGFBR2MAPK8MAPK9MAPK10SMAD2SMAD3SMAD2SMAD3SMAD2SMAD3SMAD2SMAD3MYCOncogenicpathwayHBxDDB2HBxEGR3CREBBPEP300PIK3CAPIK3R1PIK3R2PIK3CBPIK3CDPIK3R3AKT1PPAKT3PAKT2PPIKBKBPPIKBKGPCHUKBADPNFKB1RELABCL2AntiapoptosisInhibition of Fas-mediated apoptosisMAPK8MAPK9MAPK10MAP2K4YWHAQYWHABYWHAZFASLGFASFADDCASP8CASP10BIDBCL2BAXCASP3CASP12CYCSAPAF1CASP9HBxBIRC5PRKCAPRKCBPRKCGNFATC2NFATC3NFATC4pgRNAMHBsLHBsSHBsHBcAgHBeAgPHBxTranslation of viral proteinsPcccDNAcccDNAHBVpgRNAMHBsViral proteinHBVJAK2JAK3TYK2STAT3HBxSTAT1STAT2STAT4STAT5ASTAT5BSTAT6MitochondriaVDAC3Ca2+Ca2+PTK2BSRCGRB2SOS1SOS2HRASKRASNRASLHBsPRKCAPRKCBPRKCGRAF1BRAFMAP3K1MAPK8MAPK9MAPK10MAP2K1PPMAPK1PPMAPK3PPMAP2K2PPCREBBPEP300HBxJUNSMAD4STAT3ELK1FOSJUNMYCCell proliferationand differentiationCREB1ATF4ATF6BCREB5CREB3L2CREB3L4CREB3L1CREB3L3PCNACXCL8HCC developmentMMP9TLR2TLR4IFNAR1TIRAPMYD88TIRAPHBeAgHBeAgIRAK1IRAK4TICAM2TRAF6TAB1TAB2MAP3K7IKBKBPPIKBKGPPCHUKNFKB1RELAJUNMAPK9MAPK10MAP2K1PPMAPK1PPMAPK3PPMAP2K2PPMAP2K6TNFIL6MAPK12MAPK13MAPK14MAP2K4MAP2K7MAPK8MAPK9MAPK10TLR3TICAM1HBeAgTRAF3IKBKETBK1DDX3XIRF3IRF7PSTAT1STAT2MYD88DDX58IFIH1MAVSHBxIFNA1IFNA7IFNA5IFNA6IFNA4IFNA2IFNA8IFNA10IFNA13IFNA14IFNA16IFNA17IFNA21IFNA1IFNA7IFNA5IFNA6IFNA4IFNA2IFNA8IFNA10IFNA13IFNA14IFNA16IFNA17IFNA21IFNB1


Description

The Hepatitis B virus (HBV) is a virus in the Hepadnaviridae family which infects hepatocytes in the liver. It causes both acute and chronic infections, and prolonged chronic infection can lead to complications such as cirrhosis and an increased risk of hepatocellular carcinoma (HCC).

The left side of the pathway describes the pathogenesis of HBV. The virus binds NTCP (SLC10A1) and is subsequently endocytosed. It is transported to the nucleus where viral polymerase creates covalently closed circular DNA (cccDNA). Using the host RNA polymerase, this is transcribed into viral mRNAs. Viral DNA polymerase then synthesizes viral DNA via its reverse transcriptase activity. Assembled viral particles exit the cell via the ESCRT pathway.

The HBV regulatory protein HBx interferes with many cellular processes including transcription, signal transduction, cell cycle progress, protein degradation, apoptosis and chromosomal stability.

Protein phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org

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Ontology Terms

 

Bibliography

  1. ''KEGG Hepatitis B Pathway''; https://www.kegg.jp/dbget-bin/www_bget?pathway+hsa05161,
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  3. Lamontagne RJ, Bagga S, Bouchard MJ; ''Hepatitis B virus molecular biology and pathogenesis.''; Hepatoma Res, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129538view15:45, 10 May 2024EweitzModified description
129349view09:26, 27 March 2024MkutmonOntology Term : 'infectious disease pathway' added !
129348view09:25, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
127759view09:25, 3 December 2023EgonwChEBI id for Ca2+ instead of the "Ca" atom
127574view17:28, 23 October 2023KhanspersModified description
127496view18:44, 11 October 2023Khanspersadded phosphosites for BAD, fixed typo
127443view23:28, 2 October 2023Khanspersupdated AKT1 phospho sites
127355view19:24, 20 September 2023Khanspersupdated phospho sites
127251view17:40, 28 August 2023KhanspersAdded literature reference and updated description.
123495view04:55, 29 July 2022EgonwMade a pathway clickable
119241view19:10, 22 June 2021Finterlyadded KEGG biopax information
107486view21:12, 11 October 2019Khanspersremoved erroneous lit ref
105200view00:22, 19 July 2019KhanspersModified description
105199view00:16, 19 July 2019Khanspersspecify reverse transcription of cccDNA
105198view00:14, 19 July 2019KhanspersModified description
105179view22:27, 16 July 2019Khanspersfinal draft
105178view21:48, 16 July 2019Khanspersadding innate immune evasion
105177view21:13, 16 July 2019Khanspersfinalized MAPK
105176view19:04, 16 July 2019Khanspersadding MAPK
105171view18:48, 16 July 2019Khanspersadded jak/stat
105170view18:38, 16 July 2019KhanspersOntology Term : 'hepatocyte' added !
105169view18:38, 16 July 2019KhanspersOntology Term : 'hepatitis B' added !
105168view18:32, 16 July 2019KhanspersAdded legend, updated lifecycle plus lit ref
105167view16:57, 16 July 2019Khanspersreorganiation of virus life cycle content
105164view22:33, 15 July 2019KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651
AKT2GeneProductENSG00000105221 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11652
AKT3GeneProductENSG00000117020 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23797
APAF1GeneProductENSG00000120868 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
ATF4GeneProductENSG00000128272 (Ensembl)
ATF6BGeneProductENSG00000213676 (Ensembl)
ATP6AP1GeneProductENSG00000071553 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
BIRC5GeneProductENSG00000089685 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CASP10GeneProductENSG00000003400 (Ensembl)
CASP12GeneProductENSG00000204403 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16151
CREB1GeneProductENSG00000118260 (Ensembl)
CREB3GeneProductENSG00000107175 (Ensembl)
CREB3L1GeneProductENSG00000157613 (Ensembl)
CREB3L2GeneProductENSG00000182158 (Ensembl)
CREB3L3GeneProductENSG00000060566 (Ensembl)
CREB3L4GeneProductENSG00000143578 (Ensembl)
CREB5GeneProductENSG00000146592 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
Ca2+MetaboliteCHEBI:22984 (ChEBI)
DDB1GeneProductENSG00000167986 (Ensembl)
DDB2GeneProductENSG00000134574 (Ensembl)
DDX3XGeneProductENSG00000215301 (Ensembl)
DDX58GeneProductENSG00000107201 (Ensembl)
DNA Damage ResponsePathwayWP707 (WikiPathways)
EGR2GeneProductENSG00000122877 (Ensembl)
EGR3GeneProductENSG00000179388 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
ESCRT PathwayPathway
FADDGeneProductENSG00000168040 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
HSPG2GeneProductENSG00000142798 (Ensembl)
IFIH1GeneProductENSG00000115267 (Ensembl)
IFNA10GeneProduct3446 (Entrez Gene)
IFNA13GeneProduct3447 (Entrez Gene)
IFNA1GeneProduct3439 (Entrez Gene)
IFNA14GeneProduct3448 (Entrez Gene)
IFNA16GeneProduct3449 (Entrez Gene)
IFNA17GeneProduct3451 (Entrez Gene)
IFNA21GeneProduct3452 (Entrez Gene)
IFNA2GeneProduct3440 (Entrez Gene)
IFNA4GeneProduct3441 (Entrez Gene)
IFNA5GeneProduct3442 (Entrez Gene)
IFNA6GeneProduct3443 (Entrez Gene)
IFNA7GeneProduct3444 (Entrez Gene)
IFNA8GeneProduct3445 (Entrez Gene)
IFNAR1GeneProductENSG00000142166 (Ensembl)
IFNB1GeneProductENSG00000171855 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16150
IKBKEGeneProductENSG00000263528 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16151
IL6GeneProductENSG00000136244 (Ensembl)
IRAK1GeneProductENSG00000184216 (Ensembl)
IRAK4GeneProductENSG00000198001 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JAK2GeneProductENSG00000096968 (Ensembl)
JAK3GeneProductENSG00000105639 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MAP2K4GeneProductENSG00000065559 (Ensembl)
MAP2K6GeneProductENSG00000108984 (Ensembl)
MAP2K7GeneProductENSG00000076984 (Ensembl)
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAVSGeneProductENSG00000088888 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
NFATC1GeneProductENSG00000131196 (Ensembl)
NFATC2GeneProductENSG00000101096 (Ensembl)
NFATC3GeneProductENSG00000072736 (Ensembl)
NFATC4GeneProductENSG00000100968 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene)
NRASGeneProductENSG00000213281 (Ensembl)
PCNAGeneProductENSG00000132646 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706
PIK3CBGeneProductENSG00000051382 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769
PIK3CDGeneProductENSG00000171608 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707
PIK3R1GeneProductENSG00000145675 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708
PIK3R2GeneProductENSG00000105647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709
PIK3R3GeneProductENSG00000117461 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
PRKCGGeneProductENSG00000126583 (Ensembl)
PTK2BGeneProductENSG00000120899 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
SLC10A1GeneProductENSG00000100652 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT4GeneProductENSG00000138378 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)
STAT6GeneProductSTAT6 (HGNC)
TAB1GeneProductENSG00000100324 (Ensembl)
TAB2GeneProductENSG00000055208 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TICAM1GeneProductENSG00000127666 (Ensembl)
TICAM2GeneProductENSG00000243414 (Ensembl)
TIRAPGeneProductENSG00000150455 (Ensembl)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR3GeneProductENSG00000164342 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)
VDAC3GeneProductENSG00000078668 (Ensembl)
YWHABGeneProductENSG00000166913 (Ensembl)
YWHAQGeneProductENSG00000134308 (Ensembl)
YWHAZGeneProductENSG00000164924 (Ensembl)

Annotated Interactions

No annotated interactions

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