HDAC6 interactions in the central nervous system (Homo sapiens)

From WikiPathways

Revision as of 18:41, 27 November 2023 by Khanspers (Talk | contribs)
Jump to: navigation, search
2227984910662806211611643LabelVelvet Antler Polypeptides (VAP)MYH9TUBA4ABIRC5VIMVCP50, 51, 110730, 70772957, 8687HDAC6 in complex with other proteinsRegulators of HDAC6(De)acetylation activityInhibit/ReduceInteract/Bind (directional interaction)Induce/stimulateDonepeziltatOligomycin AMAP1BGSK3ASevofluraneNR3C1MYD88HDAC4SHHHSPA8KALRNHSPA4miR-218-5pITIH4PTK2BMAP3K5SEPTIN7SNCAmiR-26amiR-155-5PATP13A2LINC00461 POU5F1ARID3AOPTNPARK7NR3C1MAPRE1MIIPACTR1APXNTWIST1CYBBSTUB1ATXN3HDAC6BDNFAPOEBBIP1MAPTHDAC11ERGHDAC9SQSTM1TRIM50 UBDG3BP1TPPPPRKCESMAD2PROM1RAD23BAKT1CFTRISG15EP300SOD15373377537141410761, 1014838GRK29, 80, 108GSK3B32, 111PRKCZ80EGFR108AURKA3, 79, 81MAPK395MAPK19565, 96SIRT2HDAC6HDAC6CDC20HDAC11HSP90AA1HSF1HDAC6CTNNB1PROM1107HDAC6ELP1MAPK8HDAC615022EP400KAT5HDAC666SMAD2PCDC2077APCCDC20RAC1DLG4DLG2SNCAIPHTTELP3PPP1CAHDAC6SGK3SGK1MAP1LC3ANEDD9Aggresome-autophagy2, 54, 69, 76, 100...HDAC6HDAC6CSNK2B6PhosphorylationDCTN1GRIA2GRIA1TARDBPFUSDYNC1I2Interact/Bind (non-directional interaction)Functional interactions: regulate, modulatecontrol,assocciate,mediate,co-localize 469792Phosphorylation of HDAC6HDAC619427256060HDAC6HSPA4MAPTCSNK2A2MDH1NDUFV1MIFRHOT1CNOT6HSPA8SP1FOXP3CCDC141HIF1APRKNGARS1HSPB1CTTNCTNNB1XRCC6PRDX1PRDX2DNAJA1HSP90AA1TUBBTUBB3TUBA1CTUBA3CSMAD7tat4911717, 7110211640, 415511659, 83918734, 931097830, 587, 11638, 9012, 1610557, 8644, 52, 9443888850, 6474, 100827251112131022, 9924, 113428928, 10315, 26, 5611464116363115678384992233186836, 4710731, 393945212311437499035, 85205Chemical CompoundRNATUBA4AmiR-613HDAC6PRKCZMAPTHDAC6PRKNHSP90AA1HSF1HDAC6HDAC6PHDAC6HDAC6HDAC6HDAC6LabelAPCXRCC6BAX9127VHLHDAC6VHL108KALRNSQSTM110868BCL2BAXMethylmercury (MeHg)


Description

HDAC6 stands out as a distinctive member within the histone deacetylase family due to its predominant presence in the cytosol, facilitating its interaction with a wide array of non-histone proteins. Its dysregulation has been linked to various outcomes, encompassing diverse cancer types, immune-related disorders, and neurological conditions, including Alzheimer's, Parkinson's, ALS, Huntington's, Charcot-Marie-Tooth disease, and Rett syndrome.

The current network represents the known HDAC6 interactions in the central nervous system (CNS).

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Jianhua F, Wei W, Xiaomei L, Shao-Hui W; ''Chronic social defeat stress leads to changes of behaviour and memory-associated proteins of young mice.''; Behav Brain Res, 2017 PubMed Europe PMC Scholia
  2. Li Y, Shin D, Kwon SH; ''Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes.''; FEBS J, 2013 PubMed Europe PMC Scholia
  3. Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon SH, Garrido C, Yao TP, Vourc'h C, Matthias P, Khochbin S; ''HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.''; Genes Dev, 2007 PubMed Europe PMC Scholia
  4. Liu Z, Hao KM, Wang HY, Qi WX; ''Histone deacetylase-6 modulates amyloid beta-induced cognitive dysfunction rats by regulating PTK2B.''; Neuroreport, 2020 PubMed Europe PMC Scholia
  5. Fusco C, Micale L, Egorov M, Monti M, D'Addetta EV, Augello B, Cozzolino F, Calcagnì A, Fontana A, Polishchuk RS, Didelot G, Reymond A, Pucci P, Merla G; ''The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.''; PLoS One, 2012 PubMed Europe PMC Scholia
  6. Liesz A, Zhou W, Na SY, Hämmerling GJ, Garbi N, Karcher S, Mracsko E, Backs J, Rivest S, Veltkamp R; ''Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke.''; J Neurosci, 2013 PubMed Europe PMC Scholia
  7. Olzmann JA, Li L, Chin LS; ''Aggresome formation and neurodegenerative diseases: therapeutic implications.''; Curr Med Chem, 2008 PubMed Europe PMC Scholia
  8. Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG; ''Hdac6 regulates Tip60-p400 function in stem cells.''; Elife, 2013 PubMed Europe PMC Scholia
  9. Ageta-Ishihara N, Miyata T, Ohshima C, Watanabe M, Sato Y, Hamamura Y, Higashiyama T, Mazitschek R, Bito H, Kinoshita M; ''Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.''; Nat Commun, 2013 PubMed Europe PMC Scholia
  10. Jian W, Wei X, Chen L, Wang Z, Sun Y, Zhu S, Lou H, Yan S, Li X, Zhou J, Zhang B; ''Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.''; Neurosci Lett, 2017 PubMed Europe PMC Scholia
  11. Hu JX, Ma WJ, He LY, Zhang CH, Zhang C, Wang Y, Chen CN, Shen DY, Gao HM, Guo RR, Ning QQ, Ye XC, Cui GY, Li L; ''Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury.''; Cell Death Dis, 2022 PubMed Europe PMC Scholia
  12. Lafarga V, Aymerich I, Tapia O, Mayor F Jr, Penela P; ''A novel GRK2/HDAC6 interaction modulates cell spreading and motility.''; EMBO J, 2012 PubMed Europe PMC Scholia
  13. Wang M, Zhou C, Yu L, Kong D, Ma W, Lv B, Wang Y, Wu W, Zhou M, Cui G; ''Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage.''; Cell Mol Life Sci, 2022 PubMed Europe PMC Scholia
  14. Todd PK, Oh SY, Krans A, Pandey UB, Di Prospero NA, Min KT, Taylor JP, Paulson HL; ''Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.''; PLoS Genet, 2010 PubMed Europe PMC Scholia
  15. Youn GS, Ju SM, Choi SY, Park J; ''HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes.''; Glia, 2015 PubMed Europe PMC Scholia
  16. Beier UH, Wang L, Han R, Akimova T, Liu Y, Hancock WW; ''Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.''; Sci Signal, 2012 PubMed Europe PMC Scholia
  17. Burnett BG, Pittman RN; ''The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
  18. Mak AB, Nixon AM, Kittanakom S, Stewart JM, Chen GI, Curak J, Gingras AC, Mazitschek R, Neel BG, Stagljar I, Moffat J; ''Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation.''; Cell Rep, 2012 PubMed Europe PMC Scholia
  19. Han Y, Jeong HM, Jin YH, Kim YJ, Jeong HG, Yeo CY, Lee KY; ''Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity.''; Biochem Biophys Res Commun, 2009 PubMed Europe PMC Scholia
  20. Wenzel ED, Speidell A, Flowers SA, Wu C, Avdoshina V, Mocchetti I; ''Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120.''; Cell Death Dis, 2019 PubMed Europe PMC Scholia
  21. Zhang L, Liu S, Liu N, Zhang Y, Liu M, Li D, Seto E, Yao TP, Shui W, Zhou J; ''Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity.''; Protein Cell, 2015 PubMed Europe PMC Scholia
  22. Li X, Saiyin H, Chen X, Yu Q, Ma L, Liang W; ''Ketamine impairs growth cone and synaptogenesis in human GABAergic projection neurons via GSK-3β and HDAC6 signaling.''; Mol Psychiatry, 2022 PubMed Europe PMC Scholia
  23. Saunders HAJ, Johnson-Schlitz DM, Jenkins BV, Volkert PJ, Yang SZ, Wildonger J; ''Acetylated α-tubulin K394 regulates microtubule stability to shape the growth of axon terminals.''; Curr Biol, 2022 PubMed Europe PMC Scholia
  24. Mazzetti S, De Leonardis M, Gagliardi G, Calogero AM, Basellini MJ, Madaschi L, Costa I, Cacciatore F, Spinello S, Bramerio M, Cilia R, Rolando C, Giaccone G, Pezzoli G, Cappelletti G; ''Phospho-HDAC6 Gathers Into Protein Aggregates in Parkinson's Disease and Atypical Parkinsonisms.''; Front Neurosci, 2020 PubMed Europe PMC Scholia
  25. Govindarajalu G, Selvam M, Palchamy E, Baluchamy S; ''N-terminal truncations of human bHLH transcription factor Twist1 leads to the formation of aggresomes.''; Mol Cell Biochem, 2018 PubMed Europe PMC Scholia
  26. Beurel E; ''HDAC6 regulates LPS-tolerance in astrocytes.''; PLoS One, 2011 PubMed Europe PMC Scholia
  27. Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, Slusarski DC, Sheffield VC, Jackson PK, Nachury MV; ''A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.''; Dev Cell, 2008 PubMed Europe PMC Scholia
  28. Fukuda T, Nagashima S, Abe T, Kiyonari H, Inatome R, Yanagi S; ''Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor.''; EMBO Rep, 2016 PubMed Europe PMC Scholia
  29. Cheng F, Lienlaf M, Perez-Villarroel P, Wang HW, Lee C, Woan K, Woods D, Knox T, Bergman J, Pinilla-Ibarz J, Kozikowski A, Seto E, Sotomayor EM, Villagra A; ''Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells.''; Mol Immunol, 2014 PubMed Europe PMC Scholia
  30. He Q, Wang G, Wakade S, Dasgupta S, Dinkins M, Kong JN, Spassieva SD, Bieberich E; ''Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.''; Mol Biol Cell, 2014 PubMed Europe PMC Scholia
  31. Su M, Guan H, Zhang F, Gao Y, Teng X, Yang W; ''HDAC6 Regulates the Chaperone-Mediated Autophagy to Prevent Oxidative Damage in Injured Neurons after Experimental Spinal Cord Injury.''; Oxid Med Cell Longev, 2016 PubMed Europe PMC Scholia
  32. Ling X, Zhang G, Xia Y, Zhu Q, Zhang J, Li Q, Niu X, Hu G, Yang Y, Wang Y, Deng Z; ''Exosomes from human urine-derived stem cells enhanced neurogenesis via miR-26a/HDAC6 axis after ischaemic stroke.''; J Cell Mol Med, 2020 PubMed Europe PMC Scholia
  33. Benoy V, Van Helleputte L, Prior R, d'Ydewalle C, Haeck W, Geens N, Scheveneels W, Schevenels B, Cader MZ, Talbot K, Kozikowski AP, Vanden Berghe P, Van Damme P, Robberecht W, Van Den Bosch L; ''HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.''; Brain, 2018 PubMed Europe PMC Scholia
  34. Miskiewicz K, Jose LE, Yeshaw WM, Valadas JS, Swerts J, Munck S, Feiguin F, Dermaut B, Verstreken P; ''HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release.''; Cell Rep, 2014 PubMed Europe PMC Scholia
  35. Espallergues J, Teegarden SL, Veerakumar A, Boulden J, Challis C, Jochems J, Chan M, Petersen T, Deneris E, Matthias P, Hahn CG, Lucki I, Beck SG, Berton O; ''HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience.''; J Neurosci, 2012 PubMed Europe PMC Scholia
  36. Into T, Inomata M, Niida S, Murakami Y, Shibata K; ''Regulation of MyD88 aggregation and the MyD88-dependent signaling pathway by sequestosome 1 and histone deacetylase 6.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  37. Mahady L, Nadeem M, Malek-Ahmadi M, Chen K, Perez SE, Mufson EJ; ''Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer's Disease.''; J Alzheimers Dis, 2018 PubMed Europe PMC Scholia
  38. Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai W, Zhang X; ''Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  39. Watabe M, Nakaki T; ''Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress.''; J Cell Sci, 2011 PubMed Europe PMC Scholia
  40. Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A, Yoshida M, Wang XF, Yao TP; ''HDAC6 is a microtubule-associated deacetylase.''; Nature, 2002 PubMed Europe PMC Scholia
  41. Olzmann JA, Li L, Chudaev MV, Chen J, Perez FA, Palmiter RD, Chin LS; ''Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.''; J Cell Biol, 2007 PubMed Europe PMC Scholia
  42. Perry S, Kiragasi B, Dickman D, Ray A; ''The Role of Histone Deacetylase 6 in Synaptic Plasticity and Memory.''; Cell Rep, 2017 PubMed Europe PMC Scholia
  43. Sferra R, Pompili S, Festuccia C, Marampon F, Gravina GL, Ventura L, Di Cesare E, Cicchinelli S, Gaudio E, Vetuschi A; ''The possible prognostic role of histone deacetylase and transforming growth factor β/Smad signaling in high grade gliomas treated by radio-chemotherapy: a preliminary immunohistochemical study.''; Eur J Histochem, 2017 PubMed Europe PMC Scholia
  44. Simonsson M, Heldin CH, Ericsson J, Grönroos E; ''The balance between acetylation and deacetylation controls Smad7 stability.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  45. d'Ydewalle C, Bogaert E, Van Den Bosch L; ''HDAC6 at the Intersection of Neuroprotection and Neurodegeneration.''; Traffic, 2012 PubMed Europe PMC Scholia
  46. Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA; ''HEF1-dependent Aurora A activation induces disassembly of the primary cilium.''; Cell, 2007 PubMed Europe PMC Scholia
  47. Subramanian C, Jarzembowski JA, Opipari AW Jr, Castle VP, Kwok RP; ''HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma.''; Neoplasia, 2011 PubMed Europe PMC Scholia
  48. Yoshino Y, Roy B, Dwivedi Y; ''Corticosterone-mediated regulation and functions of miR-218-5p in rat brain.''; Sci Rep, 2022 PubMed Europe PMC Scholia
  49. Yan J, Seibenhener ML, Calderilla-Barbosa L, Diaz-Meco MT, Moscat J, Jiang J, Wooten MW, Wooten MC; ''SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity.''; PLoS One, 2013 PubMed Europe PMC Scholia
  50. Southwood CM, Peppi M, Dryden S, Tainsky MA, Gow A; ''Microtubule deacetylases, SirT2 and HDAC6, in the nervous system.''; Neurochem Res, 2007 PubMed Europe PMC Scholia
  51. Perez M, Santa-Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero JR, Sanchez-Madrid F, Dawson HN, Vitek MP, Perry G, Smith MA, Avila J; ''Tau--an inhibitor of deacetylase HDAC6 function.''; J Neurochem, 2009 PubMed Europe PMC Scholia
  52. Xu L, Zhang L, Zhang X, Li G, Wang Y, Dong J, Wang H, Hu Z, Cao X, Zhang S, Shi F; ''HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia
  53. Zilberman Y, Ballestrem C, Carramusa L, Mazitschek R, Khochbin S, Bershadsky A; ''Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.''; J Cell Sci, 2009 PubMed Europe PMC Scholia
  54. Cook C, Gendron TF, Scheffel K, Carlomagno Y, Dunmore J, DeTure M, Petrucelli L; ''Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation.''; Hum Mol Genet, 2012 PubMed Europe PMC Scholia
  55. Iwata A, Riley BE, Johnston JA, Kopito RR; ''HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  56. Birdsey GM, Dryden NH, Shah AV, Hannah R, Hall MD, Haskard DO, Parsons M, Mason JC, Zvelebil M, Gottgens B, Ridley AJ, Randi AM; ''The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis.''; Blood, 2012 PubMed Europe PMC Scholia
  57. Iaconelli J, Lalonde J, Watmuff B, Liu B, Mazitschek R, Haggarty SJ, Karmacharya R; ''Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells.''; ACS Chem Biol, 2017 PubMed Europe PMC Scholia
  58. Gal J, Chen J, Barnett KR, Yang L, Brumley E, Zhu H; ''HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  59. Fan B, Wang J, Zha D, Qiu J, Chen F; ''ATP depletion induced cochlear hair cells death through histone deacetylation in vitro.''; Neurosci Lett, 2020 PubMed Europe PMC Scholia
  60. Salian-Mehta S, Xu M, McKinsey TA, Tobet S, Wierman ME; ''Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement.''; J Biol Chem, 2015 PubMed Europe PMC Scholia
  61. Kim SH, Shanware NP, Bowler MJ, Tibbetts RS; ''Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  62. Watanabe Y, Khodosevich K, Monyer H; ''Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system.''; Cell Rep, 2014 PubMed Europe PMC Scholia
  63. Falkenberg KJ, Johnstone RW; ''Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.''; Nat Rev Drug Discov, 2014 PubMed Europe PMC Scholia
  64. Ding H, Dolan PJ, Johnson GV; ''Histone deacetylase 6 interacts with the microtubule-associated protein tau.''; J Neurochem, 2008 PubMed Europe PMC Scholia
  65. Du Y, Seibenhener ML, Yan J, Jiang J, Wooten MC; ''aPKC phosphorylation of HDAC6 results in increased deacetylation activity.''; PLoS One, 2015 PubMed Europe PMC Scholia
  66. Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B; ''HDAC6 is a target for protection and regeneration following injury in the nervous system.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  67. Ryu HW, Won HR, Lee DH, Kwon SH; ''HDAC6 regulates sensitivity to cell death in response to stress and post-stress recovery.''; Cell Stress Chaperones, 2017 PubMed Europe PMC Scholia
  68. Guo J, Lu M, Zhou Y, Wu B, Wu M; ''Effects of velvet antler polypeptides on Alzheimer's disease cell model via miR-613 HDAC6 pathway.''; Pak J Pharm Sci, 2020 PubMed Europe PMC Scholia
  69. Smith AST, Kim JH, Chun C, Gharai A, Moon HW, Kim EY, Nam SH, Ha N, Song JY, Chung KW, Doo HM, Hesson J, Mathieu J, Bothwell M, Choi BO, Kim DH; ''HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D).''; Adv Biol (Weinh), 2022 PubMed Europe PMC Scholia
  70. Yang WB, Hsu CC, Hsu TI, Liou JP, Chang KY, Chen PY, Liu JJ, Yang ST, Wang JY, Yeh SH, Chen RM, Chang WC, Chuang JY; ''Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma.''; Neuro Oncol, 2020 PubMed Europe PMC Scholia
  71. Li S, Liu X, Chen X, Zhang L, Wang X; ''Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling.''; Tumour Biol, 2015 PubMed Europe PMC Scholia
  72. Balmik AA, Chinnathambi S; ''Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling.''; Eur J Cell Biol, 2022 PubMed Europe PMC Scholia
  73. Kwon S, Zhang Y, Matthias P; ''The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response.''; Genes Dev, 2007 PubMed Europe PMC Scholia
  74. Pezzotta A, Brioschi L, Carbone S, Mazzoleni B, Bontempi V, Monastra F, Mauri L, Marozzi A, Mione M, Pistocchi A, Viani P; ''Combined Inhibition of Hedgehog and HDAC6: In Vitro and In Vivo Studies Reveal a New Role for Lysosomal Stress in Reducing Glioblastoma Cell Viability.''; Int J Mol Sci, 2023 PubMed Europe PMC Scholia
  75. Vargas EJM, Matamoros AJ, Qiu J, Jan CH, Wang Q, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S, Song Y; ''The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration.''; Genes Dev, 2020 PubMed Europe PMC Scholia
  76. Lee S, Kwon Y, Kim S, Jo M, Jeon YM, Cheon M, Kim SR, Kim K, Kim HJ; ''The Role of HDAC6 in TDP-43-Induced Neurotoxicity and UPS Impairment.''; Front Cell Dev Biol, 2020 PubMed Europe PMC Scholia
  77. Lee JB, Wei J, Liu W, Cheng J, Feng J, Yan Z; ''Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex.''; J Physiol, 2012 PubMed Europe PMC Scholia
  78. Chen Y, Wu Z, Zhu X, Zhang M, Zang X, Li X, Xu Y; ''OCT4B-190 protects against ischemic stroke by modulating GSK-3β/HDAC6.''; Exp Neurol, 2019 PubMed Europe PMC Scholia
  79. ''''; , PubMed Europe PMC Scholia
  80. ''''; ,
  81. Naftelberg S, Abramovitch Z, Gluska S, Yannai S, Joshi Y, Donyo M, Ben-Yaakov K, Gradus T, Zonszain J, Farhy C, Ashery-Padan R, Perlson E, Ast G; ''Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia.''; PLoS Genet, 2016 PubMed Europe PMC Scholia
  82. Li B, Yang Y, Wang Y, Zhang J, Ding J, Liu X, Jin Y, Lian B, Ling Y, Sun C; ''Acetylation of NDUFV1 induced by a newly synthesized HDAC6 inhibitor HGC rescues dopaminergic neuron loss in Parkinson models.''; iScience, 2021 PubMed Europe PMC Scholia
  83. Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ; ''Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment.''; Acta Neuropathol Commun, 2018 PubMed Europe PMC Scholia
  84. Sen A, Nelson TJ, Alkon DL; ''ApoE4 and Aβ Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation.''; J Neurosci, 2015 PubMed Europe PMC Scholia
  85. Wu Y, Song SW, Sun J, Bruner JM, Fuller GN, Zhang W; ''IIp45 inhibits cell migration through inhibition of HDAC6.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  86. ''''; , PubMed Europe PMC Scholia
  87. Go S, Kurita H, Hatano M, Matsumoto K, Nogawa H, Fujimura M, Inden M, Hozumi I; ''DNA methyltransferase- and histone deacetylase-mediated epigenetic alterations induced by low-level methylmercury exposure disrupt neuronal development.''; Arch Toxicol, 2021 PubMed Europe PMC Scholia
  88. ''''; , PubMed Europe PMC Scholia
  89. Mangas-Sanjuan V, Oláh J, Gonzalez-Alvarez I, Lehotzky A, Tőkési N, Bermejo M, Ovádi J; ''Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors.''; Br J Pharmacol, 2015 PubMed Europe PMC Scholia
  90. Kalinski AL, Kar AN, Craver J, Tosolini AP, Sleigh JN, Lee SJ, Hawthorne A, Brito-Vargas P, Miller-Randolph S, Passino R, Shi L, Wong VSC, Picci C, Smith DS, Willis DE, Havton LA, Schiavo G, Giger RJ, Langley B, Twiss JL; ''Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition.''; J Cell Biol, 2019 PubMed Europe PMC Scholia
  91. Li G, Du J, Wang L, Shi X; ''Developmental neurotoxicity in the context of multiple sevoflurane exposures: Potential role of histone deacetylase 6.''; Neurotoxicol Teratol, 2019 PubMed Europe PMC Scholia
  92. Parmigiani RB, Xu WS, Venta-Perez G, Erdjument-Bromage H, Yaneva M, Tempst P, Marks PA; ''HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  93. Brush MH, Guardiola A, Connor JH, Yao TP, Shenolikar S; ''Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  94. Jiang Q, Ren Y, Feng J; ''Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  95. Trzeciakiewicz H, Ajit D, Tseng JH, Chen Y, Ajit A, Tabassum Z, Lobrovich R, Peterson C, Riddick NV, Itano MS, Tripathy A, Moy SS, Lee VMY, Trojanowski JQ, Irwin DJ, Cohen TJ; ''An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline.''; Nat Commun, 2020 PubMed Europe PMC Scholia
  96. Youn GS, Cho H, Kim D, Choi SY, Park J; ''Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes.''; Redox Biol, 2017 PubMed Europe PMC Scholia
  97. Kim JY, Hwang HG, Lee JY, Kim M; ''Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development.''; Mol Brain, 2020 PubMed Europe PMC Scholia
  98. Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang XJ, Dent SR, Yao TP, Lane WS, Seto E; ''HDAC6 modulates cell motility by altering the acetylation level of cortactin.''; Mol Cell, 2007 PubMed Europe PMC Scholia
  99. Jian WX, Zhang Z, Zhan JH, Chu SF, Peng Y, Zhao M, Wang Q, Chen NH; ''Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation.''; Acta Pharmacol Sin, 2020 PubMed Europe PMC Scholia
  100. Dubois F, Alpha K, Turner CE; ''Paxillin regulates cell polarization and anterograde vesicle trafficking during cell migration.''; Mol Biol Cell, 2017 PubMed Europe PMC Scholia
  101. Fazal R, Boeynaems S, Swijsen A, De Decker M, Fumagalli L, Moisse M, Vanneste J, Guo W, Boon R, Vercruysse T, Eggermont K, Swinnen B, Beckers J, Pakravan D, Vandoorne T, Vanden Berghe P, Verfaillie C, Van Den Bosch L, Van Damme P; ''HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.''; EMBO J, 2021 PubMed Europe PMC Scholia
  102. Mo Z, Zhao X, Liu H, Hu Q, Chen XQ, Pham J, Wei N, Liu Z, Zhou J, Burgess RW, Pfaff SL, Caskey CT, Wu C, Bai G, Yang XL; ''Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy.''; Nat Commun, 2018 PubMed Europe PMC Scholia
  103. Nakashima H, Nguyen T, Goins WF, Chiocca EA; ''Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62.''; J Biol Chem, 2015 PubMed Europe PMC Scholia
  104. Dhanyamraju PK, Holz PS, Finkernagel F, Fendrich V, Lauth M; ''Histone deacetylase 6 represents a novel drug target in the oncogenic Hedgehog signaling pathway.''; Mol Cancer Ther, 2015 PubMed Europe PMC Scholia
  105. Yang W, Liu Y, Gao R, Yu H, Sun T; ''HDAC6 inhibition induces glioma stem cells differentiation and enhances cellular radiation sensitivity through the SHH/Gli1 signaling pathway.''; Cancer Lett, 2018 PubMed Europe PMC Scholia
  106. Tsai YC, Riess O, Soehn AS, Nguyen HP; ''The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation.''; PLoS One, 2012 PubMed Europe PMC Scholia
  107. Roca-Agujetas V, Barbero-Camps E, de Dios C, Podlesniy P, Abadin X, Morales A, Marí M, Trullàs R, Colell A; ''Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease.''; Mol Neurodegener, 2021 PubMed Europe PMC Scholia
  108. Wu AC, Yang WB, Chang KY, Lee JS, Liou JP, Su RY, Cheng SM, Hwang DY, Kikkawa U, Hsu TI, Wang CY, Chang WC, Chen PY, Chuang JY; ''HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells.''; J Exp Clin Cancer Res, 2022 PubMed Europe PMC Scholia
  109. Chen S, Owens GC, Makarenkova H, Edelman DB; ''HDAC6 regulates mitochondrial transport in hippocampal neurons.''; PLoS One, 2010 PubMed Europe PMC Scholia
  110. Wang R, Tan J, Chen T, Han H, Tian R, Tan Y, Wu Y, Cui J, Chen F, Li J, Lv L, Guan X, Shang S, Lu J, Zhang Z; ''ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion.''; J Cell Biol, 2019 PubMed Europe PMC Scholia
  111. Kalveram B, Schmidtke G, Groettrup M; ''The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.''; J Cell Sci, 2008 PubMed Europe PMC Scholia
  112. Gao YS, Hubbert CC, Lu J, Lee YS, Lee JY, Yao TP; ''Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis.''; Mol Cell Biol, 2007 PubMed Europe PMC Scholia
  113. Watanabe S, Inami H, Oiwa K, Murata Y, Sakai S, Komine O, Sobue A, Iguchi Y, Katsuno M, Yamanaka K; ''Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43.''; Cell Death Dis, 2020 PubMed Europe PMC Scholia
  114. Skoge RH, Ziegler M; ''SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6.''; J Cell Sci, 2016 PubMed Europe PMC Scholia
  115. Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J; ''ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.''; Dev Cell, 2020 PubMed Europe PMC Scholia
  116. Dompierre JP, Godin JD, Charrin BC, Cordelières FP, King SJ, Humbert S, Saudou F; ''Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.''; J Neurosci, 2007 PubMed Europe PMC Scholia
  117. Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP; ''The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress.''; Cell, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135049view11:00, 2 August 2024EweitzEconomize layout
134414view21:02, 21 July 2024EweitzRefine legend
134413view20:56, 21 July 2024EweitzFix typos, copyedit, standardize case
134412view20:53, 21 July 2024EweitzEconomize layout
134178view05:48, 16 July 2024EgonwRemoved duplicate and template comments
128236view18:47, 29 January 2024Khanspersconnected one interaction
127801view13:48, 16 December 2023EgonwUsed the Uniprot -TrEMBL data source (to make the link out work)
127721view18:14, 28 November 2023KhanspersOntology Term : 'PW:0001338' removed !
127717view18:44, 27 November 2023KhanspersOntology Term : 'regulatory pathway pertinent to the brain' added !
127716view18:41, 27 November 2023KhanspersOntology Term : 'histone modification pathway' added !
127662view19:44, 14 November 2023AlexanderPicoModified title
127612view14:45, 7 November 2023NasimBahramSanganiModified description
127611view14:40, 7 November 2023NasimBahramSanganiNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTR1A GeneProductENSG00000138107 (Ensembl)
AKT1 GeneProductENSG00000142208 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
APOE GeneProductENSG00000130203 (Ensembl) Type your comment here
ARID3AProteinENSG00000116017 (Ensembl)
ATP13A2ProteinENSG00000159363 (Ensembl)
ATXN3 GeneProductENSG00000066427 (Ensembl) Burnett et al. also found that ataxin-3 interacts with HDAC6 and dynein motor
AURKA GeneProductENSG00000087586 (Ensembl) AurA phosphorylates HDAC6 to activate
BAX GeneProductENSG00000087088 (Ensembl)
BBIP1 GeneProductENSG00000214413 (Ensembl)
BCL2 GeneProductENSG00000171791 (Ensembl)
BDNFGeneProductENSG00000176697 (Ensembl) Type your comment here
BIRC5GeneProductENSG00000089685 (Ensembl)
CCDC141 GeneProductENSG00000163492 (Ensembl)
CDC20 GeneProductENSG00000117399 (Ensembl)
CFTR GeneProductENSG00000001626 (Ensembl)
CNOT6ProteinENSG00000113300 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl) To verify the association of HDAC6 with CK2, we performed a pull-down assay using two recombinant proteins (GST–HDAC6 and CK2 holoenzyme) and individual subunit proteins (Fig. 2C, top). Only CK2 holoenzyme was found to be associated with HDAC6, whereas CK2α and CK2β alone failed to precipitate with HDAC6, indicating that the CK2 holoenzyme associates with HDAC6
CSNK2B GeneProductENSG00000204435 (Ensembl) To verify the association of HDAC6 with CK2, we performed a pull-down assay using two recombinant proteins (GST–HDAC6 and CK2 holoenzyme) and individual subunit proteins (Fig. 2C, top). Only CK2 holoenzyme was found to be associated with HDAC6, whereas CK2α and CK2β alone failed to precipitate with HDAC6, indicating that the CK2 holoenzyme associates with HDAC6
CTNNB1 GeneProductENSG00000168036 (Ensembl)
CTTN GeneProductENSG00000085733 (Ensembl)
CYBBGeneProductENSG00000165168 (Ensembl)
DCTN1 GeneProductENSG00000204843 (Ensembl)
DLG2 GeneProductENSG00000150672 (Ensembl)
DLG4 GeneProductENSG00000132535 (Ensembl)
DNAJA1 GeneProductENSG00000086061 (Ensembl) Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity
DYNC1I2GeneProductENSG00000077380 (Ensembl)
DonepezilMetabolite
EGFR GeneProductENSG00000146648 (Ensembl)
ELP1GeneProductENSG00000070061 (Ensembl)
ELP3GeneProductENSG00000134014 (Ensembl)
EP300 GeneProductENSG00000100393 (Ensembl)
EP400GeneProductENSG00000183495 (Ensembl)
ERGGeneProductENSG00000157554 (Ensembl)
FOXP3GeneProductENSG00000049768 (Ensembl)
FUS GeneProductENSG00000089280 (Ensembl)
G3BP1 GeneProductENSG00000145907 (Ensembl)
GARS1 GeneProductENSG00000106105 (Ensembl) Interestingly, pulldown experiments showed that HDAC6 can co-immunoprecipitate with HSPB1 (CMT2E) (Zhang et al., 2007), but also with GlyRS (CMT2D)
GRIA1 GeneProductENSG00000155511 (Ensembl)
GRIA2 GeneProductENSG00000120251 (Ensembl)
GRK2 GeneProductENSG00000173020 (Ensembl)
GSK3AGeneProductENSG00000105723 (Ensembl)
GSK3B GeneProductENSG00000082701 (Ensembl) GSK3b was found to co-localize with HDAC6 in hippocampal neurons, and inhibition of GSK3b resulted in decreased binding of antibody to phosphoserine-22, a potential GSK3b phosphorylation site in HDAC6.. We also provide evidence that GSK3b may directly regulate HDAC6.
HDAC11 GeneProductENSG00000163517 (Ensembl)
HDAC4Protein
HDAC6GeneProductENSG00000094631 (Ensembl)
HDAC9GeneProductENSG00000048052 (Ensembl)
HIF1A GeneProductENSG00000100644 (Ensembl)
HSF1 GeneProductENSG00000185122 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl)
HSPA4ProteinENSG00000170606 (Ensembl)
HSPA8 GeneProductENSG00000109971 (Ensembl)
HSPA8GeneProductENSG00000109971 (Ensembl)
HSPB1 GeneProductENSG00000106211 (Ensembl)
HTT GeneProductENSG00000197386 (Ensembl)
ISG15GeneProductENSG00000187608 (Ensembl)
ITIH4ProteinENSG00000055955 (Ensembl)
KALRNGeneProductENSG00000160145 (Ensembl)
KAT5 GeneProductENSG00000172977 (Ensembl)
LINC00461 Rna
MAP1BProteinENSG00000131711 (Ensembl)
MAP1LC3A GeneProductENSG00000101460 (Ensembl)
  • Type your comment here
  • Type your comment here
MAP3K5ProteinENSG00000197442 (Ensembl)
MAPK1 GeneProductENSG00000100030 (Ensembl)
MAPK3 GeneProductENSG00000102882 (Ensembl)
MAPK8 GeneProductENSG00000107643 (Ensembl)
MAPRE1 GeneProductENSG00000101367 (Ensembl)
MAPT GeneProductENSG00000186868 (Ensembl)
MDH1ProteinENSG00000014641 (Ensembl)
MIFProteinENSG00000240972 (Ensembl)
MIIP GeneProductENSG00000116691 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
MYH9GeneProductENSG00000100345 (Ensembl)
Methylmercury (MeHg)Metabolite
NDUFV1ProteinENSG00000167792 (Ensembl)
NEDD9 GeneProductENSG00000111859 (Ensembl)
NR3C1 GeneProductENSG00000113580 (Ensembl)
NR3C1GeneProductENSG00000113580 (Ensembl)
OPTNGeneProductENSG00000123240 (Ensembl)
Oligomycin AMetabolite
PARK7GeneProductENSG00000116288 (Ensembl)
POU5F1GeneProductENSG00000204531 (Ensembl)
PPP1CAGeneProductENSG00000172531 (Ensembl)
PRDX1 GeneProductENSG00000117450 (Ensembl)
PRDX2 GeneProductENSG00000167815 (Ensembl)
PRKCE GeneProductENSG00000171132 (Ensembl)
PRKCZ GeneProductENSG00000067606 (Ensembl) Type your comment here
PRKN GeneProductENSG00000185345 (Ensembl)
PROM1 GeneProductENSG00000007062 (Ensembl)
PROM1GeneProductENSG00000007062 (Ensembl)
PTK2BProteinENSG00000120899 (Ensembl)
PXN GeneProductENSG00000089159 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RAD23B GeneProductENSG00000119318 (Ensembl)
RHOT1ProteinENSG00000126858 (Ensembl)
SEPTIN7GeneProductENSG00000122545  (Ensembl)
SGK1 GeneProductENSG00000118515 (Ensembl)
SGK3 GeneProductENSG00000104205 (Ensembl)
SHHProteinENSG00000164690 (Ensembl)
SIRT2 GeneProductENSG00000068903 (Ensembl)
SMAD2 GeneProductENSG00000175387 (Ensembl)
SMAD7GeneProductENSG00000101665 (Ensembl) Silencing HDAC6 increased SMAD7 protein expression
SNCAProteinENSG00000145335 (Ensembl)
SNCAIP GeneProductENSG00000064692 (Ensembl)
SOD1 GeneProductENSG00000142168 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SQSTM1 GeneProductENSG00000161011 (Ensembl)
STUB1 GeneProductENSG00000103266 (Ensembl)
SevofluraneMetabolite
TARDBP GeneProductENSG00000120948 (Ensembl)
TPPP GeneProductENSG00000171368 (Ensembl)
TRIM50 GeneProductENSG00000146755 (Ensembl)
TUBA1CGeneProductENSG00000167553 (Ensembl)
TUBA3CGeneProductENSG00000198033 (Ensembl)
TUBA4AGeneProductENSG00000127824 (Ensembl)
TUBB GeneProductENSG00000196230 (Ensembl)
TUBB3 GeneProductENSG00000258947 (Ensembl)
TWIST1 GeneProductENSG00000122691 (Ensembl)
UBD GeneProductENSG00000213886 (Ensembl)
VCPGeneProductENSG00000165280 (Ensembl)
VHLGeneProductENSG00000134086 (Ensembl)
VIMProteinENSG00000026025 (Ensembl)
Velvet Antler Polypeptides (VAP)Metabolite
XRCC6 GeneProductENSG00000196419 (Ensembl)
miR-155-5PRna
miR-218-5pRna
miR-26aRna
miR-613Rna
tatGeneProduct155871 (Entrez Gene)
tatGeneProduct155871 (Uniprot-SwissProt)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5426"
Personal tools