Polycystic kidney disease pathway (Homo sapiens)

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1, 2Decreased in PKDERNucleusV2RAmTOR inhibitorsProteasomeKDRCCND1K+MTORProtein SynthesisCa2+Na+?DVL1PKD1IKBKBlixivaptanAMPKcAMPSOCMozavaptanTNFAMP Cl-RHEBTSC2RSKTSC1ERK1MAP2K2CDK inhibitorsGSK3BMetforminCa2+Ca2+Ca2+PDE1AADCY6PKATNFBRAFHRASSRCPKAPKD2IP3TriptolidePLCG2TKIsEGFIGF1VEGFBPKACFTRSSTR2V2RGNASSomatostatinVasopressinFrizzledWntsFRP4AMPADPATPNa+K+ATPaseLKB1phosJUNMYCNa+K+ATPaseNKCC1KCNN4CTNNB1PKD1PKD2PKD2PKD2ATPIncreased in PKDERK2SatavaptanTolvaptanTNF antagonistCFTR inhibitorsKCa3.1 inhibitorsCl-Cl-K+Src inhibitorsNa+K+DVL2DVL3MEK inhibitorsGNAI1GNAI2GNAI3SSTR2GNA11GNAQFLT1Ca2+Ca2+Ca2+MAP2K1NRASKRASNa+K+


Description

A putative PKD pathway proposed in Torres 2009 (Figure 2), showing up or down regulated genes.


V2R antagonists from Wikipedia.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Torres VE, Harris PC; ''Autosomal dominant polycystic kidney disease: the last 3 years.''; Kidney Int, 2009 PubMed Europe PMC Scholia
  2. ''Growth hormone synthesis, secretion and action''; https://www.genome.jp/pathway/hsa04935,

History

View all...
CompareRevisionActionTimeUserComment
132624view17:29, 7 June 2024Khanspersupdated incorrect mim-conversion to mim-binding
128611view00:43, 16 February 2024Khanspersadded missing xrefs
128391view03:07, 4 February 2024EweitzStandardize case
128240view22:44, 29 January 2024KhanspersOntology Term : 'kidney cell' added !
128239view22:43, 29 January 2024KhanspersOntology Term : 'polycystic kidney disease' added !
128238view22:41, 29 January 2024KhanspersOntology Term : 'signaling pathway' added !
128237view22:38, 29 January 2024Khanspersupdated xrefs
128118view00:35, 27 January 2024KhanspersModified description
128117view00:34, 27 January 2024Khanspersadded xrefs, updated layout
128116view23:39, 26 January 2024KhanspersModified description
128115view23:33, 26 January 2024Khanspersadded xrefs, layout
128114view22:17, 26 January 2024Khansperswork in progress: adding xrefs, changing data nodes to labels where appropriate
121723view19:25, 26 February 2022EweitzUse gene symbols
117817view14:51, 22 May 2021EweitzModified title
108308view19:54, 4 December 2019AgustinGV
108307view19:51, 4 December 2019AgustinGV
108306view19:43, 4 December 2019AgustinGV
108305view19:43, 4 December 2019AgustinGV
108304view19:40, 4 December 2019AgustinGV
108303view19:39, 4 December 2019AgustinGVAdd identifiers B-catenin/GSK3B
108302view19:35, 4 December 2019AgustinGVFix lables
108301view19:31, 4 December 2019AgustinGV
108300view19:30, 4 December 2019AgustinGV
106188view12:08, 16 August 2019MaintBotHMDB identifier normalization
97490view13:49, 23 May 2018Fehrhartadded annotations
88333view15:54, 1 August 2016FehrhartOntology Term : 'kidney disease pathway' added !
84489view23:15, 25 February 2016KhanspersQuick edit to datanode annotation or property
79790view16:02, 16 April 2015Mkutmonfixed unconnected line
78508view10:29, 7 January 2015MaintBotadded missing graphIds
78125view16:17, 4 December 2014Mkutmonadded more xrefs and some layout changes
78124view15:48, 4 December 2014Mkutmonadded some xrefs
78123view15:23, 4 December 2014Mkutmonremoved fill color since it is not ideal for visualization
74333view21:14, 12 April 2014EgonwModified description
71048view18:21, 25 September 2013EgonwAdded several identifiers.
71047view17:19, 25 September 2013EgonwCompleted entering all entities.
71046view13:06, 25 September 2013EgonwAdded identifiers for two PKD genes.
71045view11:47, 25 September 2013EgonwMore pathway content.
71044view11:16, 25 September 2013EgonwMore entities. Prob. 20% done now, excl identifiers.
71043view10:49, 25 September 2013EgonwModified description
71042view10:47, 25 September 2013EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?GeneProduct
ADCY6GeneProductADCY6 (HGNC)
ADPMetaboliteCHEBI:16761 (ChEBI)
AMP MetaboliteCHEBI:16027 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
AMPKGeneProduct
ATPMetaboliteCHEBI:15422 (ChEBI)
BRAFGeneProductENSG00000157764 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CDK inhibitorsMetabolite
CFTRGeneProductCFTR (HGNC)
CTNNB1GeneProductENSG00000168036 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cl-MetaboliteCHEBI:17996 (ChEBI)
DVL1GeneProductDVL1 (HGNC)
DVL2GeneProductDVL2 (HGNC)
DVL3GeneProductDVL3 (HGNC)
EGFGeneProductENSG00000138798 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FLT1GeneProductFLT1 (HGNC) Also known as PKD1.
Frizzled
GNA11GeneProductGNA11 (HGNC)
GNAI1GeneProductGNAI1 (HGNC)
GNAI2GeneProductGNAI2 (HGNC)
GNAI3GeneProductGNAI3 (HGNC)
GNAQGeneProductGNAQ (HGNC)
GNASGeneProductGNAS (HGNC)
GSK3BGeneProductGSK3B (HGNC)
HRASGeneProductHRAS (HGNC)
IGF1GeneProductENSG00000017427 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IP3MetaboliteCHEBI:16595 (ChEBI)
JUNGeneProductENSG00000177606 (Ensembl)
K+MetaboliteCHEBI:29103 (ChEBI)
KCNN4GeneProductKCNN4 (HGNC)
KDRGeneProductKDR (HGNC)
KRASGeneProductKRAS (HGNC)
LKB1GeneProductENSG00000118046 (Ensembl)
MAP2K1GeneProductMAP2K1 (HGNC)
MAP2K2GeneProductMAP2K2 (HGNC)
MTORGeneProductENSG00000198793 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MetforminMetaboliteCHEBI:6801 (ChEBI)
MozavaptanMetaboliteCHEBI:135694 (ChEBI)
NKCC1GeneProductENSG00000064651 (Ensembl)
NRASGeneProductNRAS (HGNC)
Na+MetaboliteCHEBI:29101 (ChEBI)
Na+K+ATPase
PDE1AGeneProductPDE1A (HGNC)
PKAGeneProductENSG00000165059 (Ensembl)
PKD1GeneProductENSG00000008710 (Ensembl) Also known as PKD1.
PKD2GeneProductENSG00000118762 (Ensembl) Also known as PKD2.
PLCG2GeneProductPLCG2 (HGNC)
Protein SynthesisPathway
RHEBGeneProductENSG00000106615 (Ensembl)
RSKGeneProduct
SOCGeneProduct
SRCGeneProductENSG00000197122 (Ensembl)
SSTR2GeneProductSSTR2 (HGNC)
SatavaptanMetaboliteQ7425965 (Wikidata)
SomatostatinMetaboliteHMDB0013072 (HMDB)
TKIsMetabolite
TNFGeneProductENSG00000204490 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TolvaptanMetaboliteCHEBI:32246 (ChEBI)
TriptolideMetaboliteCHEBI:9747 (ChEBI)
V2RAVPR2 (HGNC)
VEGFBGeneProductENSG00000173511 (Ensembl)
VasopressinMetaboliteHMDB0001980 (HMDB)
Wnt
cAMPMetaboliteCHEBI:17489 (ChEBI)
lixivaptanMetaboliteQ6659958 (Wikidata)
phos
sFRP4GeneProductENSG00000106483 (Ensembl)

Annotated Interactions

No annotated interactions

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