Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical pathway) (Homo sapiens)

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1Alveolar epitheliumCapillary endotheliumTissue lectinAlveolar spaceAEC-IIViral glycansMAC (membrane attack complex)SARS-CoV-2Cytokine stormC3Complement activationC6C7C8ACE2MASP2Coagulaton activationC5bC3AR1C5C5AR1Collectin-11Ficolin-1AEC-IIC9ACE2ECSARS-CoV-2Viral glycansBlood lectinCollectin-11Ficolin-1MASP2Complement activationC3AR1C5AR1C3C5MAC (membrane attack complex)C6C5bC7C8C9C5AR1MCMCInflammatory macrophageC5AR1C3AR1PMNC5AR1


Description

Hypothetical pathway for complement-mediated inflammation of the pulmonary alveolus in COVID-19. AEC‐II=Type II alveolar epithelial cell, EC=endothelial cells and MC=monocytes.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Polycarpou A, Howard M, Farrar CA, Greenlaw R, Fanelli G, Wallis R, Klavinskis LS, Sacks S; ''Rationale for targeting complement in COVID-19.''; EMBO Mol Med, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128306view14:35, 30 January 2024Mkutmonupdated layout
128305view14:34, 30 January 2024Mkutmonupdated layout
128304view14:32, 30 January 2024Mkutmonfix unconnected lines
124629view12:22, 18 November 2022NhungPreverse change from ACE2 (it is not viral protein)
124627view12:12, 18 November 2022NhungPchange viral protein colors
123533view06:36, 2 August 2022EgonwMade three pathways clickable
120376view23:22, 29 November 2021EweitzModified title
120342view21:43, 26 November 2021SusanModified description
120341view21:40, 26 November 2021SusanOntology Term : 'lectin complement pathway' added !
120340view21:40, 26 November 2021SusanOntology Term : 'COVID-19' added !
120339view21:39, 26 November 2021SusanOntology Term : 'epithelial cell of alveolus of lung' added !
120338view21:37, 26 November 2021SusanNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE2GeneProductENSG00000130234 (Ensembl)
C3AR1GeneProductENSG00000171860 (Ensembl)
C3GeneProductENSG00000125730 (Ensembl)
C5AR1GeneProductENSG00000197405 (Ensembl)
C5GeneProductENSG00000106804 (Ensembl)
C5bGeneProductENSG00000106804 (Ensembl)
C6GeneProductENSG00000039537 (Ensembl)
C7GeneProductENSG00000112936 (Ensembl)
C8GeneProduct731 (Entrez Gene)
C9GeneProductENSG00000113600 (Ensembl)
Coagulaton activationPathwayWP558 (WikiPathways)
Collectin-11ProteinF8WB29 (Uniprot-TrEMBL)
Complement activationPathwayWP545 (WikiPathways)
Ficolin-1ProteinO00602 (Uniprot-TrEMBL)
MASP2GeneProductENSG00000009724 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5148"
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