JAK-STAT signaling in the regulation of beta cells (Homo sapiens)
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Description
JAK-STAT signaling participates in the regulation of key biological processes in Beta-cells, including cell proliferation. Janus kinases (JAKs) serve as a fundamental switch that trigger signal transducer and activator of transcription (STAT) proteins through phosphorylation, which enables downstream target activation and subsequent regulation of target gene transcription. Suppressors of cytokine signaling (SOCS) are negative modulators of JAK-STAT signaling. This pathway is based on a figure by Jiang et al. (2018, doi: 10.3892/etm.2018.6603).
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Saving...Pathway Ontology : bone disease pathway
Disease : Adams-Oliver syndrome bone disease cleidocranial dysplasia Pallister-Hall syndrome polydactyly brachydactyly brachydactyly type A1 campomelic dysplasia acrocapitofemoral dysplasia syndactyly type 1 Robinow syndrome autosomal dominant Robinow syndrome 1 osteogenesis imperfecta spondylocostal dysostosis 1 split hand-foot malformation 6
Bibliography
- Jiang WJ, Peng YC, Yang KM; ''Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes.''; Exp Ther Med, 2018 PubMed Europe PMC Scholia
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