ATM signaling in development and disease (Homo sapiens)

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1LegendHypotonic stress PPP activationAMPKOxidative stressCSRATM substrateDNA damageV(D)JAutophagyRNF40PPP2CAReactive oxygen species NF-KBCEP63ATF2HDAC4H2AXIKBKGCHEK2ATMPP5CG6PDNBNPMID1HMGN1HMGN1CDC25AAURKBNHEJ1CDK5RNF168ATMINLMNB2SMC1ADCLRE1CHSP27Cell cycleRNF8MAPK11KAT5RNF20TP53BP1CDK2Rad50STK11MTORATMBUB1PRKDCTP53MDC1ATRRBBP8CHEK1MRE11TSC2MRE11RIF1PPP2CATRIM28ATMATMATMMRE11RAD50NBNATMNBNRAD50ATMATMImmunityDNA repairNeuronal survivalTranscriptionalsilencingChromatin retentionCheckpointactivationG1/SIntra-SG2/MSACCellular process or ATM functionMAPK12MAPK14MAPK13uH2AuH2BChromatin relaxation


Description

This pathway is modeled after Figure 4 in the article "The ATM signaling network in development and disease" (See Bibliography). When DNA is damaged, DDR begins to work on recuperating the damage through the appropriate cellular programs such as transcription, translation, etc etc. The ataxia-telangiectasia mutated (ATM) kinase acts as the main core of this pathway acting upon or receiving a lot of the reactions towards other gene products. ATM substrates use several different cell cycle checkpoints to determine the health of the DNA, and determine different types of disease/damage done to the DNA. The p38MAPK which is a reaction by ATM later leads to HSP27 which inhibits oxidative stress within the cell. DDR and ATM both work to help the cell recover from any damage it has received and understanding how ATM works will help increase doctors and scientists understanding of diseases, and their treatment. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Bibliography

  1. Stracker TH, Roig I, Knobel PA, Marjanović M; ''The ATM signaling network in development and disease.''; Front Genet, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128977view18:05, 26 February 2024Khanspersclarify connection to checkpoint activation
128958view14:50, 25 February 2024EgonwFixed a datasource
128600view02:05, 15 February 2024EweitzTweak placement
128599view02:04, 15 February 2024EweitzTuck straggling node
128598view02:01, 15 February 2024EweitzEconomize layout, standardize case
127927view19:35, 17 January 2024Khanspersupdated xrefs, lables
127911view07:10, 13 January 2024Khanspersupdated and xrefs and cleaned up pathway nodes
127910view06:34, 13 January 2024Khanspersupdated xrefs
123399view06:26, 23 July 2022EgonwMade a pathway clickable
117656view11:51, 22 May 2021EweitzModified title
106756view13:23, 17 September 2019MaintBotHMDB identifier normalization
105871view04:47, 16 August 2019KhanspersModified description
105432view04:33, 8 August 2019KhanspersModified description
89745view23:52, 29 September 2016KhanspersModified title
89623view19:41, 21 September 2016Khanspersupdated labels, some xrefs, added legend and coloring
88965view22:23, 17 August 2016AAR&CoModified description
88964view22:20, 17 August 2016AAR&CoModified description
88962view22:15, 17 August 2016AAR&CoModified description
88856view15:59, 16 August 2016AAR&CoModified description
88849view22:17, 15 August 2016AAR&CoOntology Term : 'G1 phase pathway' added !
88848view22:16, 15 August 2016AAR&CoOntology Term : 'DNA repair pathway' added !
88847view22:15, 15 August 2016AAR&CoAdded Literature Reference
88846view22:13, 15 August 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF2GeneProductENSG00000115966 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ATMINGeneProductENSG00000166454 (Ensembl)
ATRGeneProductENSG00000175054 (Ensembl)
AURKBGeneProductENSG00000178999 (Ensembl)
AutophagyPathwayWP4923 (WikiPathways)
BUB1GeneProductENSG00000169679 (Ensembl)
CDC25AGeneProductCDC25A (HGNC)
CDK2GeneProductCDK2 (HGNC)
CDK5GeneProductENSG00000164885 (Ensembl)
CEP63GeneProductENSG00000182923 (Ensembl)
CHEK1GeneProductENSG00000149554 (Ensembl)
CHEK2GeneProductENSG00000183765 (Ensembl)
Cell cyclePathwayWP45 (WikiPathways)
DCLRE1CGeneProductENSG00000152457 (Ensembl)
DNA repairPathway
G6PDGeneProductENSG00000160211 (Ensembl)
H2AXGeneProduct4739 (HGNC Accession number)
HDAC4GeneProductENSG00000068024 (Ensembl)
HMGN1GeneProductENSG00000205581 (Ensembl)
HSP27GeneProductENSG00000106211 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
KAT5GeneProductENSG00000172977 (Ensembl)
LMNB2GeneProductLMNB2 (HGNC)
MAPK11GeneProductMAPK11 (HGNC)
MAPK12GeneProductMAPK12 (HGNC)
MAPK13GeneProductMAPK13 (HGNC)
MAPK14GeneProductMAPK14 (HGNC)
MDC1GeneProductENSG00000137337 (Ensembl)
MRE11GeneProductMRE11 (HGNC)
MTORGeneProductENSG00000198793 (Ensembl)
NBNGeneProductENSG00000104320 (Ensembl)
NF-KBGeneProductENSG00000109320 (Ensembl)
NHEJ1GeneProductNHEJ1 (HGNC)
Oxidative stressPathwayWP408 (WikiPathways)
PMID1GeneProductENSG00000170836 (Ensembl)
PP5CGeneProductENSG00000011485 (Ensembl)
PPP activationPathway
PPP2CAGeneProductPPP2CA (HGNC)
PRKDCGeneProductPRKDC (HGNC)
RAD50GeneProductENSG00000113522 (Ensembl)
RBBP8GeneProductENSG00000101773 (Ensembl)
RIF1GeneProductENSG00000080345 (Ensembl)
RNF168GeneProductENSG00000163961 (Ensembl)
RNF20GeneProductENSG00000155827 (Ensembl)
RNF40GeneProductENSG00000103549 (Ensembl)
RNF8GeneProductENSG00000112130 (Ensembl)
Rad50GeneProductENSG00000113522 (Ensembl)
Reactive oxygen species MetaboliteHMDB0003125 (HMDB)
SMC1AGeneProductENSG00000072501 (Ensembl)
STK11GeneProductENSG00000118046 (Ensembl)
TP53BP1GeneProductENSG00000067369 (Ensembl)
TP53GeneProductTP53 (HGNC)
TRIM28GeneProductENSG00000130726 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)

Annotated Interactions

No annotated interactions

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