EDA signaling in hair follicle development (Homo sapiens)

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EDA protein regulation of hair follicle growth and differentiation through activation Nf-kB pathway occurring by binding of p65/p50 complex. The new protein complex of Nf-kB/p65/p50 activates Wnt and Bmp pathway inhibitors stopping induction/patterning. Nf-kB complex then binds with Ltb and Shh to activate pathways for growth and differentiation. This pathway is based on figure 4 from Cui et al.

HomologyMapper 

This pathway was inferred from Mus musculus pathway "EDA Signalling in Hair Follicle Development", WP3652 revision 89222, with a 82.0% conversion rate.