GLP-1 from intestine and pancreas and role in glucose homeostasis (Homo sapiens)

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1Pancreatic isletGlucagonPCSK2PCSK1GLP-1 from intestineInsulinGLP1RINSBeta cellGLP-1GCGAlpha cellGlucoseSLC2A1GCGAlpha cellAmino acidGLP-1


Description

Pathway of how GLP-1 produced in alpha cells in the pancreas may contribute to insulin secretion, in addition to GLP-1 from intestine. Based on Figure 4 in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190119.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Davis EM, Sandoval DA; ''Glucagon-like peptide-1: Actions and influence on pancreatic hormone function''; Comprehensive Physiology, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129188view09:57, 15 March 2024EgonwUpdated the Wikidata identifiers
129187view03:31, 15 March 2024EweitzAlign nodes
129186view03:25, 15 March 2024EweitzModified title
129185view01:44, 15 March 2024EweitzModified description
129184view01:42, 15 March 2024EweitzRefine layout
129183view01:37, 15 March 2024EweitzIdentify "GLP-1 from intestine" pathway
129182view01:35, 15 March 2024EweitzOntology Term : 'insulin secreting cell' added !
129181view01:33, 15 March 2024EweitzOntology Term : 'glucagon-like peptide-1 signaling pathway' added !
129180view01:33, 15 March 2024EweitzOntology Term : 'glucagon secretion pathway' added !
129179view01:32, 15 March 2024EweitzOntology Term : 'glucagon signaling pathway' added !
129178view01:32, 15 March 2024EweitzOntology Term : 'glucagon biosynthetic pathway' added !
129177view01:31, 15 March 2024EweitzOntology Term : 'insulin secretion pathway' added !
129176view01:31, 15 March 2024EweitzOntology Term : 'type B pancreatic cell' added !
129175view01:30, 15 March 2024EweitzOntology Term : 'pancreatic A cell' added !
129174view01:19, 15 March 2024EweitzAdd literature reference
129173view01:11, 15 March 2024EweitzIdentify remaining nodes
129172view00:55, 15 March 2024EweitzRefine layout
129171view00:53, 15 March 2024EweitzComplete adding raw nodes
129169view13:01, 14 March 2024EweitzAdd alpha cell nodes
129168view12:49, 14 March 2024EweitzTransfer more artifacts
129167view12:47, 14 March 2024EweitzAdd copy of beta cell scaffolding
129166view12:42, 14 March 2024EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Amino acidMetabolite33709 (ChEBI)
GCGGeneProductENSG00000115263 (Ensembl)
GLP-1 from intestinePathwayWP5446 (WikiPathways)
GLP-1Proteinhttps://www.wikidata.org/wiki/Q424611 (Other)
GLP1RGeneProductENSG00000112164 (Ensembl)
GlucagonProteinhttps://www.wikidata.org/wiki/Q170617 (Other)
GlucoseMetabolite17234 (ChEBI)
INSGeneProductENSG00000254647 (Ensembl)
InsulinProteinP01308 (Uniprot-TrEMBL)
PCSK1GeneProductENSG00000175426 (Ensembl)
PCSK2GeneProductENSG00000125851 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5452"
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