Hunger and satiety (Homo sapiens)

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StomachIntestineAdipose1Paraventricular nucleus (PVN)HypothalamusArcuate nucleus(ARC)GLP-1secretionLeptinMC4RHomeostatic regulation of feedingPOMCNPYAGRPLEPGHRLGCGPYYSatietyHungerGLP-1Ghrelin


Description

Effect of gut hormones on brain signaling that controls food intake. Based on Figure 1 in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959457/.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Roh, Eon, Mook Choi, Kyung; ''Hormonal Gut-Brain Signaling for the Treatment of Obesity''; International Journal of Molecular Sciences, 2023 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135860view22:36, 19 November 2024EweitzDirectly connect genes, not only proteins; send to back to avoid clash
129193view12:02, 15 March 2024EweitzAdd "GLP-1 secretion" pathway
129116view21:50, 11 March 2024EweitzReposition "Satiety" node
129115view21:44, 11 March 2024EweitzReposition other interaction
129114view21:43, 11 March 2024EweitzAdd interaction from source
129089view15:50, 10 March 2024EweitzIdentify leptin, GLP-1, ghrelin
129088view15:31, 10 March 2024EweitzAdd protein layer, where present in source
129087view15:13, 10 March 2024EweitzOntology Term : 'melanocortin system pathway' added !
129086view15:11, 10 March 2024EweitzOntology Term : 'neuron' added !
129056view13:25, 9 March 2024EweitzOntology Term : 'stomach neuroendocrine cell' added !
129055view13:20, 9 March 2024EweitzOntology Term : 'ghrelin system pathway' added !
129054view13:20, 9 March 2024EweitzOntology Term : 'ghrelin secreting cell' added !
129053view13:19, 9 March 2024EweitzOntology Term : 'enterocyte' added !
129052view13:19, 9 March 2024EweitzOntology Term : 'type L enteroendocrine cell' added !
129051view13:18, 9 March 2024EweitzOntology Term : 'adipocyte' added !
129050view13:13, 9 March 2024EweitzFix hypothalamus ID. It works!
129049view13:11, 9 March 2024EweitzIdentify hypothalamus and its paraventricular nucleus (PVN)
129048view12:59, 9 March 2024EweitzTry making ARC clickable
129047view12:53, 9 March 2024EweitzIdentify arcuate nucleus
129045view04:13, 9 March 2024EweitzIdentify tissue nodes
129044view04:09, 9 March 2024EweitzOntology Term : 'signaling pathway' added !
129043view02:37, 9 March 2024EweitzRefine stacking
129042view02:35, 9 March 2024EweitzColor tissues
129041view02:21, 9 March 2024EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AGRPGeneProductENSG00000159723 (Ensembl)
AdiposeQ193583 (Wikidata)
GCGGeneProductENSG00000115263 (Ensembl)
GHRLGeneProductENSG00000157017 (Ensembl)
GLP-1 secretionPathwayWP5446 (WikiPathways)
GLP-1Proteinhttps://www.wikidata.org/wiki/Q424611 (Other)
GhrelinProteinQ5Y392 (Uniprot-TrEMBL)
Homeostatic regulation of feedingQ5377024 (Wikidata)
HungerQ165947 (Wikidata)
IntestineQ9639 (Wikidata)
LEPGeneProductENSG00000174697 (Ensembl)
LeptinProteinP41159 (Uniprot-TrEMBL)
MC4RGeneProductENSG00000166603 (Ensembl)
NPYGeneProductENSG00000122585 (Ensembl)
POMCGeneProductENSG00000115138 (Ensembl)
PYYGeneProductENSG00000131096 (Ensembl)
Q164386 (Wikidata) Arcuate nucleus (ARC)
Q253246 (Wikidata) Arcuate nucleus (ARC)
Q444192 (Wikidata) Arcuate nucleus (ARC)
SatietyQ1562684 (Wikidata)
StomachQ1029907 (Wikidata)

Annotated Interactions

No annotated interactions

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