Hematopoietic stem cell differentiation (Homo sapiens)

From WikiPathways

Revision as of 02:31, 16 March 2024 by Eweitz (Talk | contribs)
Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none MonocyteNeutrophilBasophilRHOHLEF1ZNF835CD34GATA2FOSBIRF5T3JAMC2TAMEP TranscriptionFactor MarkersEosinophilTENXPIM1HMGN5THBS14L2CDH1HES6MUC1Erythrocyte TranscriptionFactor MarkersCSF1IL3IL6SCFCSF2NFATC2LMO2FOSSPI1IKZF1CBFA2T3MYBNCKAP1LKLF1VAV1TRIM29STAT5AKCNH2LYL1MEP-Erythocyte CommonTranscription FactorsCSF3IL3IL6SCFCSF2IL5CSF2IL3LMO2RUN1T1PBX1HLFPRDM5ZFP37iHSC ReprogrammingFactorsGATA1TPOCXCR4CD41UM279NFE2CD61MyeloblastMegakaryocyteSCFIL3IL6IL1ACSF2IL1BTPOCD34RUNX1NOTCH1EPOMXI1RIOK3ALK4MIR15AGATA1CD235aErythrocyteHematopoietic Stem Cell (HSC)Common MyeloidProgenitorSCFIL3CSF2TPOCD41CSF2MIR223MIR17MIR24AMIR155MIR181AMIR128AGATA1MIR10AMIR130AMIR223MIR155Megakaryocyte-ErythrocytePrecursor (MEP)MIR16-1MIR451ABOSPI1Erythrocyte ProgenitorMIR221MIR222MIR150MIR223MIR155FLI1GATA2PlateletsGATA1CD42LOXL3TXKGATA5WNT11HEXIM1ZGLP1EGFTGFB1LBX2ELF1ZNF792RCAN1FLI1HEXIM2NLKMED12LZNF789F2RPADI4MEF2CCRLF3PIM2Megakaryocyte TranscriptionFactor MarkersCSF3IL3IL6SCFCSF2Name: Hematopoietic stem cell differentiationOrganism: Homo sapiens


Description

Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryocytes. Adapted from an open access image attributed to ZooFari and Mikael Häggström (http://en.wikipedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m/Gallery#Medical_collaborations) and augmented from literature and NHLBI Progenitor Cell Biology Consortium (PCBC) collaborators.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Zhang L, Sankaran VG, Lodish HF; ''MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment.''; Leukemia, 2012 PubMed Europe PMC Scholia
  2. Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi DJ; ''Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.''; Cell, 2014 PubMed Europe PMC Scholia
  3. Slavov SN, Gimenes Teixeira HL, Rego EM; ''The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis.''; Braz J Med Biol Res, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129244view02:36, 16 March 2024EweitzOntology Term : 'platelet' added !
129243view02:35, 16 March 2024EweitzOntology Term : 'megakaryocyte' added !
129242view02:34, 16 March 2024EweitzOntology Term : 'erythrocyte' added !
129241view02:33, 16 March 2024EweitzOntology Term : 'monocyte' added !
129240view02:33, 16 March 2024EweitzOntology Term : 'eosinophil' added !
129239view02:33, 16 March 2024EweitzOntology Term : 'neutrophil' added !
129238view02:33, 16 March 2024EweitzOntology Term : 'basophil' added !
129237view02:31, 16 March 2024EweitzOntology Term : 'myeloblast' added !
129236view02:30, 16 March 2024EweitzOntology Term : 'common myeloid progenitor' added !
129235view02:29, 16 March 2024EweitzOntology Term : 'hematopoietic stem cell' added !
117150view09:43, 18 May 2021EweitzModified title
103039view11:57, 2 February 2019MaintBotReplaced an outdated Ensembl identifiers with the new one.
102164view22:12, 4 December 2018Khanspersupdated xrefs for miRNAs
97552view14:50, 24 May 2018Mkutmonfix some of the uniprot identifiers
89818view11:53, 6 October 2016MkutmonModified description
84764view18:34, 16 March 2016KhanspersReverted to version '04:17, 18 November 2015' by Khanspers
84763view18:14, 16 March 2016WRothReverted to version '20:29, 28 September 2014' by WRoth
84762view18:14, 16 March 2016WRothReverted to version '22:37, 29 September 2014' by WRoth
84761view18:14, 16 March 2016WRothReverted to version '20:25, 28 September 2014' by WRoth
84760view18:14, 16 March 2016WRothReverted to version '20:28, 28 September 2014' by WRoth
84759view18:14, 16 March 2016WRothReverted to version '22:53, 29 September 2014' by WRoth
84758view18:14, 16 March 2016WRothReverted to version '20:39, 29 September 2014' by WRoth
84757view18:14, 16 March 2016WRothReverted to version '20:30, 28 September 2014' by WRoth
84756view18:14, 16 March 2016WRothReverted to version '18:11, 29 September 2014' by WRoth
84755view18:13, 16 March 2016WRothReverted to version '20:32, 28 September 2014' by WRoth
84754view18:13, 16 March 2016WRothReverted to version '22:51, 29 September 2014' by WRoth
84753view18:13, 16 March 2016WRothReverted to version '22:54, 29 September 2014' by WRoth
84752view18:13, 16 March 2016WRothReverted to version '23:17, 29 September 2014' by WRoth
84751view18:13, 16 March 2016WRothReverted to version '23:20, 29 September 2014' by WRoth
84750view18:13, 16 March 2016WRothReverted to version '23:15, 29 September 2014' by WRoth
84749view18:13, 16 March 2016WRothReverted to version '23:32, 29 September 2014' by WRoth
84748view18:13, 16 March 2016WRothReverted to version '23:22, 29 September 2014' by WRoth
84747view18:13, 16 March 2016WRothReverted to version '23:27, 29 September 2014' by WRoth
84746view18:13, 16 March 2016WRothReverted to version '00:10, 30 September 2014' by WRoth
84745view18:13, 16 March 2016WRothReverted to version '23:46, 29 September 2014' by WRoth
84744view18:13, 16 March 2016WRothReverted to version '00:14, 30 September 2014' by WRoth
84743view18:12, 16 March 2016WRothReverted to version '00:26, 30 September 2014' by WRoth
84742view18:12, 16 March 2016WRothReverted to version '00:16, 30 September 2014' by WRoth
84741view18:12, 16 March 2016WRothReverted to version '01:41, 30 September 2014' by WRoth
84740view18:12, 16 March 2016WRothReverted to version '00:50, 30 September 2014' by WRoth
84739view18:12, 16 March 2016WRothReverted to version '00:41, 30 September 2014' by WRoth
84738view18:12, 16 March 2016WRothReverted to version '18:09, 30 September 2014' by WRoth
84737view18:12, 16 March 2016WRothReverted to version '02:09, 30 September 2014' by WRoth
84736view18:12, 16 March 2016WRothReverted to version '17:58, 30 September 2014' by WRoth
84735view18:12, 16 March 2016WRothReverted to version '18:47, 30 September 2014' by WRoth
84734view18:12, 16 March 2016WRothReverted to version '19:13, 30 September 2014' by WRoth
84733view18:12, 16 March 2016WRothReverted to version '18:11, 30 September 2014' by WRoth
84732view18:12, 16 March 2016WRothReverted to version '18:53, 30 September 2014' by WRoth
84731view18:12, 16 March 2016WRothReverted to version '20:06, 30 September 2014' by WRoth
84730view18:11, 16 March 2016WRothReverted to version '19:45, 30 September 2014' by WRoth

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ABOGeneProductENSG00000175164 (Ensembl)
ALK4GeneProductENSG00000135503 (Ensembl)
C2TAGeneProductP33076 (Uniprot-TrEMBL)
CBFA2T3GeneProductENSG00000129993 (Ensembl)
CD235aGeneProductENSG00000170180 (Ensembl)
CD34GeneProduct
CD34GeneProductP28906 (Uniprot-TrEMBL)
CD41GeneProductENSG00000005961 (Ensembl)
CD42GeneProductENSG00000169704 (Ensembl)
CD61GeneProduct3690 (Entrez Gene)
CDH1GeneProductCDH1 (Uniprot-TrEMBL)
CRLF3GeneProductCRLF3 (Uniprot-TrEMBL)
CSF1GeneProductENSG00000184371 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
EGFGeneProductEGF (Uniprot-TrEMBL)
ELF1GeneProductELF1 (Uniprot-TrEMBL)
EPOGeneProductENSG00000130427 (Ensembl)
F2RGeneProductF2R (Uniprot-TrEMBL)
FLI1GeneProductENSG00000151702 (Ensembl)
FLI1GeneProductFLI1 (Uniprot-TrEMBL)
FOSBGeneProductP53539 (Uniprot-TrEMBL)
FOSGeneProductENSG00000170345 (Ensembl)
GATA1GeneProductENSG00000102145 (Ensembl)
GATA2GeneProductENSG00000179348 (Ensembl)
GATA2GeneProductP23769 (Uniprot-TrEMBL)
GATA5GeneProductGATA5 (Uniprot-TrEMBL)
HES6GeneProductQ96HZ4 (Uniprot-TrEMBL)
HEXIM1GeneProductHEXIM1 (Uniprot-TrEMBL)
HEXIM2GeneProductHEXIM2 (Uniprot-TrEMBL)
HLFGeneProductHLF (Uniprot-TrEMBL)
HMGN5GeneProductP82970 (Uniprot-TrEMBL)
IKZF1GeneProductENSG00000185811 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL3GeneProductENSG00000164399 (Ensembl)
IL5GeneProductENSG00000113525 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IRF5GeneProductQ13568 (Uniprot-TrEMBL)
KCNH2GeneProductENSG00000055118 (Ensembl)
KLF1GeneProductENSG00000105610 (Ensembl)
LBX2GeneProductLBX2 (Uniprot-TrEMBL)
LEF1GeneProductQ9UJU2 (Uniprot-TrEMBL)
LMO2GeneProductENSG00000135363 (Ensembl)
LMO2GeneProductLMO2 (Uniprot-TrEMBL)
LOXL3GeneProductLOXL3 (Uniprot-TrEMBL)
LYL1GeneProductENSG00000104903 (Ensembl)
MED12LGeneProductMED12L (Uniprot-TrEMBL)
MEF2CGeneProductMEF2C (Uniprot-TrEMBL)
MIR10ARnaMIMAT0000253 (miRBase mature sequence)
MIR128ARnaENSG00000207654 (Ensembl)
MIR130ARnaENSG00000208009 (Ensembl)
MIR150RnaENSG00000207782 (Ensembl)
MIR155RnaMIMAT0000165 (miRBase mature sequence)
MIR15AGeneProductENSG00000283785 (Ensembl)
MIR16-1GeneProductENSG00000208006 (Ensembl)
MIR17RnaMIMAT0000070 (miRBase mature sequence)
MIR181ARnaENSG00000207759 (Ensembl)
MIR221RnaENSG00000207870 (Ensembl)
MIR222RnaENSG00000207870 (Ensembl)
MIR223GeneProductENSG00000284567 (Ensembl)
MIR24ARnaENSG00000207617 (Ensembl)
MIR451RnaMIMAT0001631 (miRBase mature sequence)
MUC1GeneProductP15941 (Uniprot-TrEMBL)
MXI1GeneProductENSG00000119950 (Ensembl)
MYBGeneProductENSG00000118513 (Ensembl)
NCKAP1LGeneProductENSG00000123338 (Ensembl)
NFATC2GeneProductENSG00000101096 (Ensembl)
NFE2GeneProductENSG00000123405 (Ensembl)
NLKGeneProductNLK (Uniprot-TrEMBL)
NOTCH1GeneProductENSG00000148400 (Ensembl)
PADI4GeneProductPADI4 (Uniprot-TrEMBL)
PBX1GeneProductPBX1 (Uniprot-TrEMBL)
PIM1GeneProductP11309 (Uniprot-TrEMBL)
PIM2GeneProductPIM2 (Uniprot-TrEMBL)
PRDM5GeneProductPRDM5 (Uniprot-TrEMBL)
RCAN1GeneProductRCAN1 (Uniprot-TrEMBL)
RHOHGeneProductQ15669 (Uniprot-TrEMBL)
RIOK3GeneProductENSG00000101782 (Ensembl)
RUN1T1GeneProductRUN1T1 (Uniprot-TrEMBL)
RUNX1GeneProductENSG00000159216 (Ensembl)
S14L2GeneProductO76054 (Uniprot-TrEMBL)
SCFGeneProductENSG00000049130 (Ensembl)
SPI1GeneProductENSG00000066336 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
T3JAMGeneProductQ9Y228 (Uniprot-TrEMBL)
TENXGeneProductP22105 (Uniprot-TrEMBL)
TGFB1GeneProductTGFB1 (Uniprot-TrEMBL)
THBGeneProductP10828 (Uniprot-TrEMBL)
TPOGeneProductENSG00000115705 (Ensembl)
TRIM29GeneProductENSG00000137699 (Ensembl)
TXKGeneProductTXK (Uniprot-TrEMBL)
UM279Metabolite
  • http://www.google.com/patents/CA2862140A1?cl=en
  • Patented derivative of Pyrimido[4,5-b]indole
VAV1GeneProductENSG00000141968 (Ensembl)
WNT11GeneProductWNT11 (Uniprot-TrEMBL)
ZFP37GeneProductZFP37 (Uniprot-TrEMBL)
ZGLP1GeneProductZGLP1 (Uniprot-TrEMBL)
ZNF789GeneProductZNF789 (Uniprot-TrEMBL)
ZNF792GeneProductZNF792 (Uniprot-TrEMBL)
ZNF835GeneProductQ9Y2P0 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2849"
Personal tools