Thymic stromal lymphopoietin (TSLP) signaling (Homo sapiens)
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Description
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine involved in regulation of a broad spectrum of biological processes. The TSLP receptor complex consists of the IL-7 receptor alpha subunit and its unique TSLPR subunit (gene symbol CRLF2). TSLP can be secreted by epithelial cells upon pathogen stimulation. TSLP can also activate dendritic cells, CD4+ T cells and CD8+ T cells. TSLP not only activate the JAK/STAT pathway but also induce phosphorylation of other signaling molecules including PI3K/Akt, ERK1/2 and JNKs. Aberrant TSLP signaling is implicated in a number of the development of diseases, including asthma, atopic dermatitis, eosinophilic eosophagitis and acute lymphoid leukemia.
Description source: NetPath
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.Quality Tags
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Ontology Terms
Saving...Pathway Ontology : disease pathway
Disease : familial chylomicronemia syndrome congenital generalized lipodystrophy type 4 congenital generalized lipodystrophy type 3 hyperlipoproteinemia type V familial hyperlipidemia lipodystrophy familial partial lipodystrophy type 1 hyperlipoproteinemia type III congenital generalized lipodystrophy type 1 lipid metabolism disorder familial hypercholesterolemia hypolipoproteinemia familial partial lipodystrophy type 2 familial partial lipodystrophy type 6 acquired generalized lipodystrophy congenital generalized lipodystrophy type 2 familial partial lipodystrophy type 3 familial partial lipodystrophy type 4 familial partial lipodystrophy type 5 hyperlipoproteinemia type IV familial combined hyperlipidemia abetalipoproteinemia Norum disease Tangier disease
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