Estrogen signaling (Homo sapiens)
From WikiPathways
Description
Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Quality Tags
Ontology Terms
Bibliography
- Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
- Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
- Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
BCL2 apoptotic switch | GeneProduct | 596 (Entrez Gene) | |
C-FOS | GeneProduct | 2353 (Entrez Gene) | |
CHUK | GeneProduct | 1147 (Entrez Gene) | |
CREB | GeneProduct | 1385 (Entrez Gene) | |
Cyclic AMP | Metabolite | HMDB0000058 (HMDB) | |
ELK | GeneProduct | 2002 (Entrez Gene) | |
ER-AF1 | GeneProduct | 2099 (Entrez Gene) | |
ER-AF2 | GeneProduct | 2099 (Entrez Gene) | |
ER | GeneProduct | 2099 (Entrez Gene) | |
ERE | GeneProduct | 2099 (Entrez Gene) | |
ERK 1/2 | GeneProduct | ENSG00000100030 (Ensembl) | |
Estradiol | Metabolite | HMDB0000151 (HMDB) | |
GFRs | GeneProduct | 2099 (Entrez Gene) | |
GNB1 | GeneProduct | 2782 (Entrez Gene) | |
GNGT1 | GeneProduct | 2792 (Entrez Gene) | |
GPR30 | GeneProduct | 2852 (Entrez Gene) | |
GSA | GeneProduct | 2778 (Entrez Gene) | |
Growth factors | Metabolite | HMDB0000151 (HMDB) | |
IKBKB | GeneProduct | 3551 (Entrez Gene) | |
IKBKG | GeneProduct | 8517 (Entrez Gene) | |
JNKs | GeneProduct | 5601 (Entrez Gene) | |
MAPKK | GeneProduct | ENSG00000169032 (Ensembl) | |
MAPKKK | GeneProduct | 673 (Entrez Gene) | |
NFKB | GeneProduct | 4790 (Entrez Gene) | |
Non-ERE | GeneProduct | 2099 (Entrez Gene) | |
PI3K | GeneProduct | 5290 (Entrez Gene) | |
PKACA | GeneProduct | 5566 (Entrez Gene) | |
PKB/Akt | GeneProduct | 207 (Entrez Gene) | |
SP1 | GeneProduct | 6667 (Entrez Gene) | |
TF | GeneProduct | 2099 (Entrez Gene) | |
c-Jun | GeneProduct | 3725 (Entrez Gene) | |
p38 | GeneProduct | 1432 (Entrez Gene) |
Annotated Interactions
No annotated interactions