miRNA regulation of prostate cancer signaling (Homo sapiens)

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1Cell proliferationSurvivalNucleusARNFKBIANFKB1BCL2PSADNAApoptosisMIR3682PIP3PI3K-Akt signalingCCND1MAP2K1MIR589CREBBPTP53PDGFAMIR1299MIR4325MIR4763MIR548MIR3120MIR3664MIR4311MIR363PDGFRBMIR200AMIR30DMIR4664MIR603MIR3149MIR466MIR3714MIR603MIR3664MIR30DMIR466MIR337MIR4311MIR30DMIR4517PIK3CAGRB2SOS1KRASRAF1PMAPK1MIR3714PAKT3CASP9BADPFOXO1PCDKN1ACDKN1BPMDM2PGSK3BPIKBKGPMTORPPARCell cycleprogressionCREB3L1PCTNNB1POther target eventsTumor growthDNACell survivalTCF7DNACell proliferationDNAImpaired G1 and G2 arrestReduced apoptosisGenomic instabillityp53 signalingpathwayCytokine-cytokinereceptor interactionMAP2K2MAPK signalingCell cycle


Description

Diagrammatic scheme depicting potential survival pathway-related gene targets of the downregulated microRNAs and their signaling pathways in prostate cancer cells. An integrated in silico and computational prediction databases (DIANA-micro T-CDS, miRBase, and TargetScan) were employed to predict potential targets of a subset of highly downregulated miRNAs (>2-fold) in prostate tumors. Note that some targeting miRNAs were removed from the original publication figure for clarity. These are represented in supplementary table S3: http://journals.sagepub.com/doi/suppl/10.1177/1535370216681554.

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Bibliography

  1. Moustafa AA, Ziada M, Elshaikh A, Datta A, Kim H, Moroz K, Srivastav S, Thomas R, Silberstein JL, Moparty K, Salem FE, El-Habit OH, Abdel-Mageed AB; ''Identification of microRNA signature and potential pathway targets in prostate cancer.''; Exp Biol Med (Maywood), 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
130804view12:52, 30 May 2024EweitzWP5198
129791view12:12, 22 May 2024EweitzMake more pathways clickable, indicate which aren't
129759view02:18, 22 May 2024EweitzFormalize pathway node
129758view02:16, 22 May 2024EweitzRefine interactions with apoptosis pathway
129757view02:14, 22 May 2024EweitzStandardize pathway node color, case
129756view01:59, 22 May 2024EweitzModified title
108114view10:21, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
97532view14:25, 24 May 2018MaxvansonChanging some identifiers for better linkage to other databases
96402view10:17, 12 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94297view21:19, 31 August 2017KhanspersModified description
94295view21:16, 31 August 2017Khanspersremoved miRNAs that could not be found
92307view18:59, 19 May 2017KhanspersOntology Term : 'prostate cancer' added !
92306view18:59, 19 May 2017KhanspersModified description
92305view18:58, 19 May 2017Khanspersremoved comment
92304view18:58, 19 May 2017Khanspersremoved database where no ID
92303view18:57, 19 May 2017KhanspersModified title
92302view18:57, 19 May 2017KhanspersModified title
92300view18:48, 19 May 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT3GeneProductENSG00000117020 (Ensembl)
ARGeneProduct367 (Entrez Gene)
ApoptosisPathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CREB3L1GeneProductENSG00000157613 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
Cell cyclePathwayWP179 (WikiPathways)
DNAMetaboliteCHEBI:16991 (ChEBI)
FOXO1GeneProductENSG00000150907 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK signalingPathwayWP382 (WikiPathways)
MAPK1GeneProductENSG00000100030 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MIR1299RnaENSG00000275377 (Ensembl)
MIR200ARnaENSG00000207607 (Ensembl)
MIR30DRnaENSG00000199153 (Ensembl)
MIR3120RnaENSG00000283152 (Ensembl)
MIR3149RnaENSG00000266712 (Ensembl)
MIR337RnaENSG00000199151 (Ensembl)
MIR363RnaMI0000764 (miRBase Sequence) Annotated with MIMAT because BridgeDb version not yet up-to-date with latest
MIR3664RnaENSG00000263744 (Ensembl)
MIR3682RnaENSG00000265452 (Ensembl)
MIR3714RnaMI0016135 (miRBase Sequence) Annotated with MIMAT because BridgeDb version not yet up-to-date with latest
MIR3714RnaMIMAT0018165 (miRBase mature sequence) Annotated with MIMAT because BridgeDb version not yet up-to-date with latest
MIR4311RnaENSG00000263512 (Ensembl)
MIR4325RnaENSG00000266666 (Ensembl)
MIR4517RnaMI0016883 (miRBase Sequence) Annotated with MIMAT because BridgeDb version not yet up-to-date with latest
MIR4664RnaENSG00000265660 (Ensembl)
MIR466RnaENSG00000265376 (Ensembl)
MIR4763RnaMI0017404 (miRBase Sequence) Annotated with MIMAT because BridgeDb version not yet up-to-date with latest
MIR548Rnamirbase: no human MIR548
MIR589RnaENSG00000207973 (Ensembl)
MIR603RnaENSG00000207930 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
PDGFAGeneProductENSG00000197461 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PI3K-Akt signalingPathwayWP4172 (WikiPathways)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PSAGeneProductENSG00000142515 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
TCF7GeneProductENSG00000081059 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)

Annotated Interactions

No annotated interactions

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