Nod-like receptor (NLR) signaling pathway (Rattus norvegicus)

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2-74p20degradationp10NACHTInflammasome pathwayp20transcriptionCARDNACHTPYDCaspase-1p10NACHTTAB2TAB1IκBαCARDKDPYDNACHTPYDCARDCARDIL-1� and IL-18NALP3RIP2ASCNACHTPYDNod1Nod2PYDK63-linked UbTriDAPIkbkgCd40IkbkbDAMPSRelAMDPMap3k7CARDEphb2CARDERBB2IPCARDMAPKChukMapk8CARD


Description

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP288(r28883) with a 50% conversion rate.

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Bibliography

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  1. Shaw MH, Reimer T, Kim YG, Nu�ez G; ''NOD-like receptors (NLRs): bona fide intracellular microbial sensors.''; Curr Opin Immunol, 2008 PubMed Europe PMC Scholia
  2. Carneiro LA, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH; ''Nod-like proteins in inflammation and disease.''; J Pathol, 2008 PubMed Europe PMC Scholia
  3. Mariathasan S, Monack DM; ''Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.''; Nat Rev Immunol, 2007 PubMed Europe PMC Scholia
  4. Kufer TA; ''Signal transduction pathways used by NLR-type innate immune receptors.''; Mol Biosyst, 2008 PubMed Europe PMC Scholia
  5. Meylan E, Tschopp J, Karin M; ''Intracellular pattern recognition receptors in the host response.''; Nature, 2006 PubMed Europe PMC Scholia
  6. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE; ''Nod-like proteins in immunity, inflammation and disease.''; Nat Immunol, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134206view19:14, 16 July 2024EgonwRemoved an empty, unused reference
134205view19:13, 16 July 2024EgonwRemoved template comments
117030view14:02, 16 May 2021EweitzModified title
71833view19:38, 18 October 2013MaintBotremoved data source from nodes without identifier
70189view01:58, 13 July 2013AlexanderPicoModified title
69931view19:58, 11 July 2013MaintBotModified description
69929view19:57, 11 July 2013MaintBotupdating to 2013 schema
67510view11:18, 26 June 2013DdiglesOntology Term : 'NOD-like receptor signaling pathway' added !
41737view02:39, 2 March 2011MaintBotRemoved redundant pathway information and comments
34110view19:23, 9 December 2009MaintBotAutomatic update of empty xrefs
32308view13:19, 15 August 2009MaintBotFixed text labels
31895view12:44, 14 August 2009MaintBotFixed group labels
31336view20:23, 13 August 2009MaintBotFixed text labels
30975view00:51, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CARDGeneProduct
Cd40GeneProduct171369 (Entrez Gene)
ChukGeneProduct309361 (Entrez Gene)
DAMPSMetabolite
ERBB2IPGeneProduct365662 (Entrez Gene)
Ephb2GeneProduct313633 (Entrez Gene)
IkbkbGeneProduct84351 (Entrez Gene)
IkbkgGeneProduct309295 (Entrez Gene)
MAPKGeneProduct
MDPMetabolite
Map3k7GeneProduct313121 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
RelAGeneProduct309165 (Entrez Gene)
TriDAPMetabolite

Annotated Interactions

No annotated interactions
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