Male steroid hormones in cardiomyocyte energy metabolism (Homo sapiens)
From WikiPathways
Description
This pathway depicts the effect of testosterone and androstanedione on energy metabolism in cardiomyocytes.
Quality Tags
Ontology Terms
Bibliography
- Carbajal-García A, Reyes-García J, Montaño LM; ''Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes.''; Int J Endocrinol, 2020 PubMed Europe PMC Scholia
- Ishizaki F, Nishiyama T, Kawasaki T, Miyashiro Y, Hara N, Takizawa I, Naito M, Takahashi K; ''Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer.''; Sci Rep, 2013 PubMed Europe PMC Scholia
- Davey RA, Grossmann M; ''Androgen Receptor Structure, Function and Biology: From Bench to Bedside.''; Clin Biochem Rev, 2016 PubMed Europe PMC Scholia
- McEwan IJ, Brinkmann AO; ''Androgen Physiology: Receptor and Metabolic Disorders.''; , 2021 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
17a Hydroxypregnenolone | Metabolite | HMDB0000363 (HMDB) | |
17β-HSD | Protein | CHEMBL4234 (EMBL) | |
17β-HSD | Protein | Q9BPX1 (Uniprot-TrEMBL) | |
3α-Androstane-diol | Metabolite | 5879 (PubChem-compound) | |
3α-Etiocholane-diol | Metabolite | 5880 (PubChem-compound) | |
3α-HSD | Protein | P80701 (Uniprot-TrEMBL) | |
3β-Androstane-diol | Metabolite | 441302 (PubChem-compound) | |
3β-Eticholane-diol | Metabolite | 247732 (PubChem-compound) | |
3β-HSD2 | GeneProduct | P26439 (Uniprot-TrEMBL) | |
3β-HSD | Protein | Q9N119 (Uniprot-TrEMBL) | |
5α-Dihydro-testosterone | Metabolite | 10635 (PubChem-compound) | |
5β-Dihydro-testosterone | Metabolite | 11302 (PubChem-compound) | |
AKR1C3 | Protein | A0A0A0MSS8 (Uniprot-TrEMBL) | |
AKR1C3 | GeneProduct | A0A0A0MSS8 (Uniprot-TrEMBL) | |
Androgen Receptor (AR) | Metabolite | HMDB0001624 (HMDB) | |
Androstanedione | Metabolite | HMDB0000053 (HMDB) | |
Androstenedione | Metabolite | HMDB0000053 (HMDB) | |
Aromatase | Protein | P11511 (Uniprot-TrEMBL) | |
CYP11A1 | Protein | P05108 (Uniprot-TrEMBL) | |
CYP17A1 (17α-hydroxylase) | Protein | P05093 (Uniprot-TrEMBL) | |
CYP17A1 (C17,20-lyase) | Protein | P05093 (Uniprot-TrEMBL) | |
DHEA | Metabolite | CHEBI:28689 (ChEBI) | |
Epiandrosterone | Metabolite | HMDB0000365 (HMDB) | |
Epietiocholanolone | Metabolite | HMDB0000546 (HMDB) | |
Etiocholanolone | Metabolite | HMDB0000490 (HMDB) | |
Glucuronosyl- transferase | Protein | P22309 (Uniprot-TrEMBL) | |
HSD17B2 | Protein | P37059 (Uniprot-TrEMBL) | |
HSD17B3 | GeneProduct | P37058 (Uniprot-TrEMBL) | |
HSD3B1 | GeneProduct | ENSG00000203857.10 (Ensembl) | |
HSD3B1 | GeneProduct | P14060 (Uniprot-TrEMBL) | |
HSD3B2 | GeneProduct | ENSG00000203859.10 (Ensembl) | |
HSD3B2 | GeneProduct | P26439 (Uniprot-TrEMBL) | |
SRD5A1/5α-reductase | GeneProduct | P18405 (Uniprot-TrEMBL) | |
SRD5A1 | GeneProduct | ENSG00000145545.12 (Ensembl) | |
SRD5A2/5β-reductase | GeneProduct | P31213 (Uniprot-TrEMBL) | |
SRD5A2 | GeneProduct | ENSG00000277893.2 (Ensembl) | |
Sulfotransferase | Protein | P50225 (Uniprot-TrEMBL) | |
Testosterone glucuronide | Metabolite | CHEBI:28835 (ChEBI) | |
Testosterone-sulfate | Metabolite | 119207 (PubChem-compound) | |
androstenediol | Metabolite | Q2817108 (Wikidata) | |
androsterone | Metabolite | Q422469 (Wikidata) | |
cholesterol | Metabolite | CHEBI:16113 (ChEBI) | |
estrone | Metabolite | CHEBI:17263 (ChEBI) | |
oestradiol | Metabolite | CHEBI:23965 (ChEBI) | |
pregnenolone | Metabolite | CHEBI:16581 (ChEBI) | |
progesterone | Metabolite | CHEBI:17026 (ChEBI) | |
testosterone | Metabolite | CHEBI:17347 (ChEBI) |
Annotated Interactions
No annotated interactions