Burn wound healing (Homo sapiens)

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Upregulated genesLPS21, 47PGE221PGS223EGF7GROA22hsa-miR-4485-3p43CXCL1448TPM353VIM53PFN153SPARC53TLR421, 44IL84, 21, 48IL621, 48CCL221MYD8821hsa-miR-181b23PGS223ACHA735ACES35hsa-miR-29a39, 50GAS539HCP539MIAT39LINC0033839LN28A39hsa-miR-29b-3p49XIST39, 49hsa-miR-12626SCEL26VEGFA14, 26, 50COL1A226, 50MMP926, 51HOTAIR26TGFB210CNN210TGFB310FST34COL1A15, 25, 34, 39, 49INHBA34AKT134P36CXCR44, 47CXCL124, 47SMAD3P8BRD48FN18, 48Col1A18NOX48TAGLN8IFNA214, 30, 47KLF41MIR1451BCL229, 38SFRP229SNAI229IFNB140KDR4025PECAM132ACTA18, 9, 27, 30, 32...SERPINH132NFKB132TGFB17, 8, 11, 23, 27...IL1B32, 48MIR29B132TNF32COL1A132MIR29B132MMP135FBN115TNC15ELN15ICAM120CXCR222TAGL48IL1A48TNFAIP348NFKBIZ48NFKBIA48ADAM1248FOXE148CD24848FILA37K2C6A37MMP2831MMP151MMP351TIMP151TIMP251MMP251TLR121TLR221TLR321TLR521TLR621TLR721TLR821TLR921NOD121NOD221LY9621S10A617S10A917S10AB17SLUR135ACh35HMGB135CASP335SFRP228SNAI228PECAM114SERPINH125bsmA 9F13A19FGFR13FGFR23FGFR33FGFR43CD3E45IL1518Col1a1b5HGF33CXCR44Cspg441PDGFRb41Krt22241TP5316Activin24Sulfate42HEXD6AMBP42Sequencing dataDownregulated genesUp- & down-regulated genesNOTCH212, 52MMP712, 52JAG212, 52LGLAS1HULC1344MIR663B44MMP144TIMP144TPT1BAX3838CASP3CDK1638hsa-miR-324-5p3844


Description

This pathway is part of a systematic review on currently known molecular players in burn wound healing in mammalians.

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Bibliography

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  1. Avniel S, Arik Z, Maly A, Sagie A, Basst HB, Yahana MD, Weiss ID, Pal B, Wald O, Ad-El D, Fujii N, Arenzana-Seisdedos F, Jung S, Galun E, Gur E, Peled A; ''Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns.''; J Invest Dermatol, 2006 PubMed Europe PMC Scholia
  2. Ali-Bahar M, Bauer B, Tredget EE, Ghahary A; ''Dermal fibroblasts from different layers of human skin are heterogeneous in expression of collagenase and types I and III procollagen mRNA.''; Wound Repair Regen, 2004 PubMed Europe PMC Scholia
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  10. Ghahary A, Marcoux Y, Karimi-Busheri F, Tredget EE; ''Keratinocyte differentiation inversely regulates the expression of involucrin and transforming growth factor beta1.''; J Cell Biochem, 2001 PubMed Europe PMC Scholia
  11. Chen L, Wang Z, Li S, Zhao G, Tian M, Sun Z; ''SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars.''; PLoS One, 2012 PubMed Europe PMC Scholia
  12. Costa AM, Peyrol S, Pôrto LC, Comparin JP, Foyatier JL, Desmoulière A; ''Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars.''; Am J Pathol, 1999 PubMed Europe PMC Scholia
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  15. Fumagalli M, Musso T, Vermi W, Scutera S, Daniele R, Alotto D, Cambieri I, Ostorero A, Gentili F, Caposio P, Zucca M, Sozzani S, Stella M, Castagnoli C; ''Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin.''; Exp Dermatol, 2007 PubMed Europe PMC Scholia
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  17. Ding J, Hori K, Zhang R, Marcoux Y, Honardoust D, Shankowsky HA, Tredget EE; ''Stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 in the formation of postburn hypertrophic scar (HTS).''; Wound Repair Regen, 2011 PubMed Europe PMC Scholia
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  20. Wang J, Chen H, Shankowsky HA, Scott PG, Tredget EE; ''Improved scar in postburn patients following interferon-alpha2b treatment is associated with decreased angiogenesis mediated by vascular endothelial cell growth factor.''; J Interferon Cytokine Res, 2008 PubMed Europe PMC Scholia
  21. Kwan P, Ding J, Tredget EE; ''MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar.''; PLoS One, 2015 PubMed Europe PMC Scholia
  22. Nedelec B, Shankowsky H, Scott PG, Ghahary A, Tredget EE; ''Myofibroblasts and apoptosis in human hypertrophic scars: the effect of interferon-alpha2b.''; Surgery, 2001 PubMed Europe PMC Scholia
  23. Ijaz T, Jamaluddin M, Zhao Y, Zhang Y, Jay J, Finnerty CC, Herndon DN, Tilton RG, Brasier AR; ''Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation.''; Cell Death Dis, 2017 PubMed Europe PMC Scholia
  24. Gras C, Ratuszny D, Hadamitzky C, Zhang H, Blasczyk R, Figueiredo C; ''miR-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity.''; Mol Med, 2015 PubMed Europe PMC Scholia
  25. Wu J, Ma B, Yi S, Wang Z, He W, Luo G, Chen X, Wang X, Chen A, Barisoni D; ''Gene expression of early hypertrophic scar tissue screened by means of cDNA microarrays.''; J Trauma, 2004 PubMed Europe PMC Scholia
  26. Hermanns-Lê T, Piérard GE, Jennes S, Piérard-Franchimont C; ''Protomyofibroblast Pathway in Early Thermal Burn Healing.''; Skin Pharmacol Physiol, 2015 PubMed Europe PMC Scholia
  27. Rong HT, Liu DW; ''Identification of differentially expressed miRNAs associated with thermal injury in epidermal stem cells based on RNA-sequencing.''; Exp Ther Med, 2020 PubMed Europe PMC Scholia
  28. Chan RK, Zamora DO, Wrice NL, Baer DG, Renz EM, Christy RJ, Natesan S; ''Development of a vascularized skin construct using adipose-derived stem cells from debrided burned skin.''; Stem Cells Int, 2012 PubMed Europe PMC Scholia
  29. Cao W, Feng Y; ''LncRNA XIST promotes extracellular matrix synthesis, proliferation and migration by targeting miR-29b-3p/COL1A1 in human skin fibroblasts after thermal injury.''; Biol Res, 2019 PubMed Europe PMC Scholia
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  34. Wang J, Hori K, Ding J, Huang Y, Kwan P, Ladak A, Tredget EE; ''Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring.''; J Cell Physiol, 2011 PubMed Europe PMC Scholia
  35. Neely AN, Brown RL, Clendening CE, Orloff MM, Gardner J, Greenhalgh DG; ''Proteolytic activity in human burn wounds.''; Wound Repair Regen, 1997 PubMed Europe PMC Scholia
  36. Nanney LB, Mueller SG, Bueno R, Peiper SC, Richmond A; ''Distributions of melanoma growth stimulatory activity of growth-regulated gene and the interleukin-8 receptor B in human wound repair.''; Am J Pathol, 1995 PubMed Europe PMC Scholia
  37. Zhu Y, Li Z, Wang Y, Li L, Wang D, Zhang W, Liu L, Jiang H, Yang J, Cheng J; ''Overexpression of miR-29b reduces collagen biosynthesisby inhibiting heat shock protein 47 during skin wound healing.''; Transl Res, 2016 PubMed Europe PMC Scholia
  38. ''''; , PubMed Europe PMC Scholia
  39. ''''; , PubMed Europe PMC Scholia
  40. Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, Zhang P, Huang X; ''Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury.''; Biol Open, 2016 PubMed Europe PMC Scholia
  41. Costa AM, Peyrol S, Pôrto LC, Comparin JP, Foyatier JL, Desmoulière A; ''Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars.''; Am J Pathol, 1999 PubMed Europe PMC Scholia
  42. ''''; , PubMed Europe PMC Scholia
  43. Wang J, Chen H, Shankowsky HA, Scott PG, Tredget EE; ''Improved scar in postburn patients following interferon-alpha2b treatment is associated with decreased angiogenesis mediated by vascular endothelial cell growth factor.''; J Interferon Cytokine Res, 2008 PubMed Europe PMC Scholia
  44. ''''; , PubMed Europe PMC Scholia
  45. ''''; , PubMed Europe PMC Scholia
  46. Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, Zhang P, Huang X; ''Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury.''; Biol Open, 2016 PubMed Europe PMC Scholia
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  49. Jiang B, Tang Y, Wang H, Chen C, Yu W, Sun H, Duan M, Lin X, Liang P; ''Down-regulation of long non-coding RNA HOTAIR promotes angiogenesis via regulating miR-126/SCEL pathways in burn wound healing.''; Cell Death Dis, 2020 PubMed Europe PMC Scholia
  50. Evdokiou A, Kanisicak O, Gierek S, Barry A, Ivey MJ, Zhang X, Bodnar RJ, Satish L; ''Characterization of Burn Eschar Pericytes.''; J Clin Med, 2020 PubMed Europe PMC Scholia
  51. Castagnoli C, Stella M, Magliacani G, Ferrone S, Richiardi PM; ''Similar ectopic expression of ICAM-1 and HLA class II molecules in hypertrophic scars following thermal injury.''; Burns, 1994 PubMed Europe PMC Scholia
  52. Guo L, Huang X, Liang P, Zhang P, Zhang M, Ren L, Zeng J, Cui X; ''Role of XIST/miR-29a/LIN28A pathway in denatured dermis and human skin fibroblasts (HSFs) after thermal injury.''; J Cell Biochem, 2018 PubMed Europe PMC Scholia
  53. Holmes CJ, Plichta JK, Gamelli RL, Radek KA; ''Burn Injury Alters Epidermal Cholinergic Mediators and Increases HMGB1 and Caspase 3 in Autologous Donor Skin and Burn Margin.''; Shock, 2017 PubMed Europe PMC Scholia

History

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135209view01:57, 8 August 2024EweitzReduce node-interaction occlusion
135208view01:55, 8 August 2024EweitzAlign nodes, economize layout
135207view01:51, 8 August 2024EweitzEconomize layout
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135197view00:57, 8 August 2024EweitzGroup formally not only graphically, economize layout
135196view00:51, 8 August 2024EweitzAdjust background color contrast for readability
134364view06:06, 21 July 2024EgonwCleaned up the references
134363view06:01, 21 July 2024EgonwRemoved template comments
122621view08:42, 22 April 2022ExperiMeddeleted a wrong node
122620view08:41, 22 April 2022ExperiMedupdated/added nodes, edges and references
120278view13:44, 23 November 2021EgonwClean up of two references
119583view07:17, 21 July 2021ExperiMedModified description
119552view10:47, 15 July 2021ExperiMedOntology Term : 'immune response pathway' added !
119551view10:47, 15 July 2021ExperiMedOntology Term : 'keratinocyte' added !
119550view10:46, 15 July 2021ExperiMedOntology Term : 'endothelial cell' added !
119549view10:46, 15 July 2021ExperiMedOntology Term : 'myofibroblast cell' added !
119548view10:46, 15 July 2021ExperiMedOntology Term : 'fibroblast' added !
119547view10:28, 15 July 2021ExperiMedOntology Term : 'cell-extracellular matrix signaling pathway' added !
119546view10:19, 15 July 2021ExperiMedFixed Interaction
117667view11:58, 22 May 2021EweitzModified title
116240view17:07, 21 April 2021EgonwUse Uniprot-TrEMBL instead of Uniprot-SwissProt
115827view23:10, 15 March 2021Khanspersminor change to trigger update
115639view10:08, 3 March 2021ExperiMedadded full references
115373view16:29, 16 February 2021ExperiMedNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACESProteinP22303 (Uniprot-TrEMBL)
ACHA7ProteinP36544 (Uniprot-TrEMBL)
ACTA1ProteinP68133 (Uniprot-TrEMBL)
AChMetaboliteHMDB0000895 (HMDB)
ADAM12RnaENSG00000148848 (Ensembl) pericytes
AKT1ProteinP31749 (Uniprot-TrEMBL)
AMBPProteinP02760 (Uniprot-TrEMBL) Uronic acid
ActivinProteinFibroblasts, Histiocytes, Endothelial cells, Lymphocytes
BAXProteinQ07812 (Uniprot-TrEMBL)
BCL2ProteinP10415 (Uniprot-TrEMBL)
BRD4ProteinO60885 (Uniprot-TrEMBL)
CASP3ProteinP42574 (Uniprot-TrEMBL)
CCL2ProteinP13500 (Uniprot-TrEMBL) pericytes
CD248RnaENSG00000174807 (Ensembl) pericytes
CD3EProteinP07766 (Uniprot-TrEMBL) Fibroblasts
CDK16ProteinQ00536 (Uniprot-TrEMBL)
CNN2RnaENSG00000064666 (Ensembl)
COL1A1ProteinP02452 (Uniprot-TrEMBL)
COL1A2ProteinP08123 (Uniprot-TrEMBL)
CXCL12ProteinP48061 (Uniprot-TrEMBL) SDF1
CXCL14RnaENSG00000145824 (Ensembl) pericytes
CXCR2ProteinP25025 (Uniprot-TrEMBL)
CXCR4ProteinP61073 (Uniprot-TrEMBL) Fibroblasts
Col1A1RnaENSG00000108821 (Ensembl)
Col1a1bRnaENSDARG00000035809 (Ensembl) Fibroblasts
Cspg4ProteinQ8VHY0 (Uniprot-TrEMBL)
EGFProteinP01133 (Uniprot-TrEMBL)
ELNProteinP15502 (Uniprot-TrEMBL)
F13A1ProteinP00488 (Uniprot-TrEMBL)
FBN1ProteinP35555 (Uniprot-TrEMBL)
FGFR1ProteinP11362 (Uniprot-TrEMBL)
FGFR2ProteinP21802 (Uniprot-TrEMBL)
FGFR3ProteinP22607 (Uniprot-TrEMBL)
FGFR4ProteinP22455 (Uniprot-TrEMBL)
FILAProteinP20930 (Uniprot-TrEMBL) pericytes
FN1RnaENSG00000115414 (Ensembl)
FOXE1ProteinO00358 (Uniprot-TrEMBL) pericytes
FSTGeneProductP19883 (Uniprot-TrEMBL)
GAS5RnaENSG00000234741 (Ensembl) pericytes
GROAProteinP09341 (Uniprot-TrEMBL)
HCP5RnaENSG00000237105 (Ensembl) pericytes
HEXDProteinQ8WVB3 (Uniprot-TrEMBL)
HGFProteinP14210 (Uniprot-TrEMBL)
HMGB1ProteinP09429 (Uniprot-TrEMBL)
HOTAIRRnaENSG00000228630 (Ensembl) pericytes
HULCRnaENSG00000285219 (Ensembl)
ICAM1ProteinP05362 (Uniprot-TrEMBL)
IFNA2ProteinP01563 (Uniprot-TrEMBL)
IFNB1ProteinP01574 (Uniprot-TrEMBL)
IL15ProteinP40933 (Uniprot-TrEMBL) Fibroblasts
IL1ARnaENSG00000115008 (Ensembl) pericytes
IL1BProteinP01584 (Uniprot-TrEMBL)
IL6ProteinP05231 (Uniprot-TrEMBL) pericytes
IL8ProteinP10145 (Uniprot-TrEMBL) pericytes
INHBAProteinP08476 (Uniprot-TrEMBL) = Activin A = EDF
JAG2ProteinP97607 (Uniprot-TrEMBL)
K2C6AProteinP02538 (Uniprot-TrEMBL) pericytes
KDRRnaENSG00000128052 (Ensembl) VEGFR2
KLF4ProteinO43474 (Uniprot-TrEMBL)
Krt222ProteinQ8N1A0 (Uniprot-TrEMBL)
LGLAS1ProteinP09382 (Uniprot-TrEMBL)
LINC00338RnaENSG00000234912 (Ensembl) pericytes
LN28AProteinQ9H9Z2 (Uniprot-TrEMBL)
LPSMetabolite53481794 (PubChem-substance)
LY96RnaENSG00000154589 (Ensembl) pericytes
MIATRnaENSG00000225783 (Ensembl) pericytes
MIR145RnaENSG00000276365 (Ensembl)
MIR29B1ProteinENSG00000283797 (Ensembl)
MIR663BRnaENSG00000221288 (Ensembl)
MMP13RnaENSG00000137745 (Ensembl) Fibroblasts
MMP1RnaENSG00000196611 (Ensembl) pericytes
MMP1ProteinP03956 (Uniprot-TrEMBL)
MMP28ProteinQ9H239 (Uniprot-TrEMBL) pericytes
MMP2ProteinP08253 (Uniprot-TrEMBL) pericytes
MMP3RnaENSG00000149968 (Ensembl) pericytes
MMP7ProteinP50280 (Uniprot-TrEMBL)
MMP9ProteinP14780 (Uniprot-TrEMBL)
MYD88ProteinQ99836 (Uniprot-TrEMBL) pericytes
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKBIARnaENSG00000100906 (Ensembl) pericytes
NFKBIZRnaENSG00000144802 (Ensembl) pericytes
NOD1RnaENSG00000106100 (Ensembl) pericytes
NOD2RnaENSG00000167207 (Ensembl) pericytes
NOTCH2ProteinQ9QW30 (Uniprot-TrEMBL)
NOX4ProteinQ9NPH5 (Uniprot-TrEMBL)
PDGFRbProteinP09619 (Uniprot-TrEMBL)
PECAM1ProteinP16284 (Uniprot-TrEMBL)
PFN1RnaENSG00000108518 (Ensembl) pericytes
PGE2MetaboliteHMDB0060041 (HMDB)
PGS2ProteinP07585 (Uniprot-TrEMBL)
S10A6ProteinP06703 (Uniprot-TrEMBL)
S10A9ProteinP06702 (Uniprot-TrEMBL)
S10ABProteinP31949 (Uniprot-TrEMBL)
SCELProteinO95171 (Uniprot-TrEMBL)
SERPINH1ProteinP50454 (Uniprot-TrEMBL) HSP47
SFRP2ProteinQ96HF1 (Uniprot-TrEMBL) Fibroblasts
SLUR1ProteinP55000 (Uniprot-TrEMBL)
SMAD3ProteinP84022 (Uniprot-TrEMBL)
SNAI2ProteinO43623 (Uniprot-TrEMBL) Fibroblasts
SPARCRnaENSG00000113140 (Ensembl) pericytes
SulfateMetaboliteHMDB0001448 (HMDB)
TAGLNRnaENSG00000149591 (Ensembl)
TAGLProteinQ01995 (Uniprot-TrEMBL) pericytes
TGFB1ProteinP01137 (Uniprot-TrEMBL)
TGFB2ProteinP61812 (Uniprot-TrEMBL)
TGFB3ProteinP10600 (Uniprot-TrEMBL)
TIMP1RnaENSG00000102265 (Ensembl) pericytes
TIMP1ProteinP01033 (Uniprot-TrEMBL)
TIMP2RnaENSG00000035862 (Ensembl) pericytes
TLR1RnaENSG00000174125 (Ensembl) pericytes
TLR2RnaENSG00000137462 (Ensembl) pericytes
TLR3RnaENSG00000164342 (Ensembl) pericytes
TLR4ProteinO00206 (Uniprot-TrEMBL) pericytes
TLR5RnaENSG00000187554 (Ensembl) pericytes
TLR6RnaENSG00000174130 (Ensembl) pericytes
TLR7RnaENSG00000196664 (Ensembl) pericytes
TLR8RnaENSG00000101916 (Ensembl) pericytes
TLR9RnaENSG00000239732 (Ensembl) pericytes
TNCProteinP24821 (Uniprot-TrEMBL)
TNFAIP3RnaENSG00000118503 (Ensembl) pericytes
TNFProteinP01375 (Uniprot-TrEMBL)
TP53ProteinP04637 (Uniprot-TrEMBL)
TPM3RnaENSG00000174807 (Ensembl) pericytes
TPT1ProteinP13693 (Uniprot-TrEMBL)
VEGFAProteinP15692 (Uniprot-TrEMBL)
VIMRnaENSG00000026025 (Ensembl) pericytes
XISTRnaENSG00000229807 (Ensembl) pericytes
bsmA ProteinP39297 (Uniprot-TrEMBL)
hsa-miR-126RnaMI0000471 (miRBase Sequence)
hsa-miR-181bRnaMI0003331 (miRBase Sequence)
hsa-miR-29aRnaMI0000087 (miRBase Sequence)
hsa-miR-29b-3pRnaMIMAT0000100 (miRBase Sequence)
hsa-miR-324-5pRnaMIMAT0000761 (miRBase Sequence)
hsa-miR-4485-3pRnaMI0016846 (miRBase Sequence)

Annotated Interactions

No annotated interactions

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