Clock-controlled autophagy in bone metabolism (Homo sapiens)

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1E BoxSimulationAutolysosmeOsteocyteOsteoclastOsteoblastOsteogenesisAutophagosomeLysosomeOsteoclastogenesisCLOCKARNTLPER1CRY1MTORULK1ATG13NFATC1ATG5ATG16L1ATG12BECN1RANKLRB1CC1PIK3C3ATG101OPGRANKAMBRA1CTSKP115BECN1SMAD8SMAD5SMAD1AMPKBMP1LAMP2WNT16SEMA3AWNT5ATRAPMAP1LC3AMAP1LC3BIGF1DKK1SEMA4DS1PWNT10BCTHRC1EFNB2CT-1TGFB1RUNX2NFATC1LEPRORBNPAS2NR1D2BHLHE40BHLHE41NOTCH1BCL2VCPFYCO1PLEKHM1DRAM2BMP2BMP4BMPR2BMP5BMP6CALCAVCPSMAD4SERPINF1PTHCSF1JAK2LRP5CHRDMEPEMEPEAKT1ATG10HMGB1SQSTM1RUNX2PTHIL3IL6ATG7SOSTCircadian rhythm genesATG4CATG7ATG5BMPNOTCH1ATG3VCPIL3,6,7TRAF6PTHBMP7InhibitionBindingCatalysisCoexistence relationFlowRev-ErbMMP9CX3CR1IL1/4/6/7TNF-aWNT6WNT10aSP7ATG4AutophagophoreLegend


Description

This integrated pathway shows cross-talk among circadian rhythm, autophagy and osteoclast/osteoblast differentiation pathways. Other pathways are shown as activators and/or inhibitors of the bone remodeling process.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Glister C, Regan SL, Samir M, Knight P; ''Gremlin, Noggin, Chordin and follistatin differentially modulate BMP induced suppression of androgen secretion by bovine ovarian theca cells.''; J Mol Endocrinol, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135245view00:10, 9 August 2024EweitzModified description
135244view00:07, 9 August 2024EweitzStandardize node shape
135243view00:01, 9 August 2024EweitzRefine legend
135242view23:55, 8 August 2024EweitzFix typos
122560view02:17, 16 April 2022EweitzOntology Term : 'osteocyte' added !
122559view02:16, 16 April 2022EweitzModified title
122484view21:23, 12 April 2022KhanspersModified title
121998view07:51, 9 March 2022Haseena
121929view13:44, 8 March 2022HaseenaOntology Term : 'osteoblast' added !
121928view13:43, 8 March 2022HaseenaModified description
121927view13:37, 8 March 2022HaseenaOntology Term : 'osteoclast' added !
121926view13:36, 8 March 2022HaseenaOntology Term : 'autophagy pathway' added !
121923view13:12, 8 March 2022HaseenaUn connected lines has been connected. the legends have been changed to grphical lines.
121809view19:58, 6 March 2022HaseenaModified description
121808view19:54, 6 March 2022HaseenaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AMBRA1GeneProductENSG00000110497 (Ensembl)
AMPKGeneProductENSG00000162409 (Ensembl)
ARNTLGeneProductENSG00000133794 (Ensembl)
ATG101GeneProductENSG00000123395 (Ensembl)
ATG10GeneProductENSG00000152348 (Ensembl)
ATG12GeneProductENSG00000145782 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
ATG16L1GeneProductENSG00000085978 (Ensembl)
ATG3GeneProductENSG00000144848 (Ensembl)
ATG4CGeneProductENSG00000125703 (Ensembl)
ATG4GeneProductENSG00000197548 (Ensembl)
ATG5GeneProductENSG00000057663 (Ensembl)
ATG7GeneProductENSG00000197548 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BECN1GeneProductENSG00000126581 (Ensembl)
BHLHE40GeneProductENSG00000134107 (Ensembl)
BHLHE41GeneProductENSG00000123095 (Ensembl)
BMP1GeneProductENSG00000125845 (Ensembl)
BMP2GeneProductENSG00000152785 (Ensembl)
BMP4GeneProductENSG00000125378 (Ensembl)
BMP5GeneProductENSG00000112175 (Ensembl)
BMP6GeneProductENSG00000153162 (Ensembl)
BMP7GeneProductENSG00000153162 (Ensembl)
BMPMetaboliteCHEBI:60815 (ChEBI)
BMPR2GeneProductENSG00000204217 (Ensembl)
CALCAGeneProductENSG00000110680 (Ensembl)
CHRDGeneProductENSG00000090539 (Ensembl)
CLOCKGeneProductENSG00000134852 (Ensembl)
CRY1GeneProductENSG00000008405 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CT-1GeneProductENSG00000150281 (Ensembl)
CTHRC1GeneProductENSG00000164932 (Ensembl)
CTSKGeneProductENSG00000143387 (Ensembl)
CX3CR1GeneProductENSG00000008405 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
DRAM2GeneProductENSG00000156171 (Ensembl)
EFNB2GeneProductENSG00000125266 (Ensembl)
FYCO1GeneProductENSG00000163820 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IL1/4/6/7GeneProductENSG00000120659 (Ensembl)
IL3,6,7GeneProductENSG00000164399 (Ensembl)
IL3GeneProductENSG00000164399 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
JAK2GeneProductENSG00000096968 (Ensembl)
LAMP2GeneProductENSG00000005893 (Ensembl)
LEPGeneProductENSG00000174697 (Ensembl)
LRP5GeneProductENSG00000162337 (Ensembl)
MAP1LC3AGeneProductENSG00000101460 (Ensembl)
MAP1LC3BGeneProductENSG00000140941 (Ensembl)
MEPEGeneProductENSG00000152595 (Ensembl)
MMP9GeneProductENSG00000008405 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NFATC1GeneProductENSG00000131196 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
NPAS2GeneProductENSG00000170485 (Ensembl)
NR1D2GeneProductENSG00000174738 (Ensembl)
OPGGeneProductENSG00000164761 (Ensembl)
P115GeneProductENSG00000089820 (Ensembl)
PER1GeneProductENSG00000179094 (Ensembl)
PIK3C3GeneProductENSG00000078142 (Ensembl)
PLEKHM1GeneProductENSG00000225190 (Ensembl)
PTHGeneProductENSG00000152266 (Ensembl)
RANKGeneProductENSG00000120659 (Ensembl)
RANKLGeneProductENSG00000141655 (Ensembl)
RB1CC1GeneProductENSG00000023287 (Ensembl)
RORBGeneProductENSG00000198963 (Ensembl)
RUNX2GeneProductENSG00000124813 (Ensembl)
Rev-ErbGeneProductENSG00000008405 (Ensembl)
S1PMetaboliteCHEBI:37550 (ChEBI)
SEMA3AGeneProductENSG00000075213 (Ensembl)
SEMA4DGeneProductENSG00000187764 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
SMAD1GeneProductENSG00000170365 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SMAD5GeneProductENSG00000113658 (Ensembl)
SMAD8GeneProductENSG00000120693 (Ensembl)
SOSTGeneProductENSG00000167941 (Ensembl)
SP7GeneProductENSG00000170374 (Ensembl)
SQSTM1GeneProductENSG00000161011 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TNF-aGeneProductENSG00000120659 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
TRAPGeneProductENSG00000126602 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
VCPGeneProductENSG00000165280 (Ensembl)
WNT10BGeneProductENSG00000169884 (Ensembl)
WNT10aGeneProductENSG00000114251 (Ensembl)
WNT16GeneProductENSG00000002745 (Ensembl)
WNT5AGeneProductENSG00000114251 (Ensembl)
WNT6GeneProductENSG00000114251 (Ensembl)

Annotated Interactions

No annotated interactions

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