LIN-12/Notch Lateral Signaling (Caenorhabditis elegans)

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1LIN-122lst-1lst-222lst-42ark-12lip-12dpy-232lst-3LET-2322LET-602MPK-12sli-1unc-10122apm-12gap-12


Description

Lateral signaling targets and negative regulation of LET-23 signaling. The LIN-12/Notch pathway plays two related roles in vulval development; to prevent adjacent induced vulval precursor cells (VPCs) from both becoming 1° VPCs and to induce VPCs adjacent to the 1°VPC to take a 2° cell fate.

See figure 14 in http://www.wormbook.org/chapters/www_vulvaldev/vulvaldev.pdf.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Yoo AS, Bais C, Greenwald I; ''Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development.''; Science, 2004 PubMed Europe PMC Scholia
  2. Sternberg PW; ''Vulval development.''; WormBook, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135359view07:01, 31 August 2024EgonwConverted to use Ensembl identifiers
135294view20:52, 15 August 2024KhanspersModified description
135293view20:46, 15 August 2024Khanspersfixed unconnected
135292view20:44, 15 August 2024KhanspersModified description
135291view20:40, 15 August 2024Khansperslayout, groups
118383view13:56, 27 May 2021RaatsSfixed unconnected arrow
73849view00:50, 26 February 2014MaintBotupdating schema
53149view02:12, 30 October 2012MaintBotModified categories
48973view19:22, 2 July 2012KyookModified description
48972view19:21, 2 July 2012Kyookfixing description
48938view23:47, 29 June 2012KyookOntology Term : 'Notch signaling pathway' added !
48937view23:47, 29 June 2012Kyookfinished pathway
48936view23:43, 29 June 2012KyookPeriodical save, work in progress
48935view23:29, 29 June 2012KyookNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
LET-23GeneProductZK1067.1 (WormBase)
LET-60GeneProductZK792.6 (WormBase)
LIN-12GeneProductR107.8 (WormBase)
MPK-1GeneProductF43C1.2 (WormBase)
apm-1GeneProductF55A12.7 (WormBase)
ark-1GeneProductC01C7.1 (WormBase)
dpy-23GeneProductR160.1 (WormBase)
gap-1GeneProductT24C12.2 (WormBase)
lip-1GeneProductC05B10.1 (WormBase)
lst-1GeneProductT22A3.3 (WormBase)
lst-2GeneProductR160.7 (WormBase)
lst-3GeneProductY37A1B.1 (WormBase)
lst-4GeneProductY37A1B.2 (WormBase)
sli-1GeneProductM02A10.3 (WormBase)
unc-101GeneProductK11D2.3 (WormBase)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2223"
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