Cobalamin B12, folate B riboflavin B2 pathway into methionine cycle and folate cycle (Homo sapiens)

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IntestinestomachMitochondriacblFcblBcbLCmethionine synthase interactomeFolateCyclecytosol (intracellular)MethionineCyclevitamin B12hydroxocobalaminsarcosineTHF-polyglutamateFMN162SAMe113HCFC1 (cblX)35, 138, 190THF52CBSSLC46A1glycine betaineFOLH1915-MTHFAdoCblMeCbl(III)alaminMTRRB9RFK162SAH113FLAD1SLC19A1BHMT78DHFR53, 66Met113SLC52A26FOLR1TYMS158DNMT1TCN2acetateSLC52A16DHFMTR113SLC52A36MTHFRB26, 113, 162ALDH1L2AHCYcystathioninehomocysteine113MAT1AMAT2BB95, 10-MTHFPG52SHMT110-formyl-THF52MTHFD15-MTHFFOLR2B95-MTHF5-10MeTHFFADB26, 113, 162FMN162Lysosome47122ABCD4138, 148Succinyl-CoAMMUTCD320R-cob(III)alamin14831cob(I)alamincbLAMMAAMethylmalonyl-CoALMBRD1138MMACHC138, 148FMNMMABPLPPLPMMADHC138, 148MMADHC138, 148Cobalamin (B12) Pathwaycob(II)alaminMMACHCFAD138, 148FADMMACHCFAD138, 148cbLCcob(II)alamin148cob(II)alamin148MMACHC138, 148FADcblD-1MMADHCcob(II)alamin138, 148MMACHC148cblD-2138, 148FMN162MMAAepithelial cells122122TCN2TCN1CUBN179CblcobalaminsTCN1Cbl179CblCBLIFCBLIFCblCBLIFAMNCblTCN2179CBLIF122TCN1179B2B26, 113, 162Cbl6, 113, 162Cbl179Intercellular179IntestineMMACHC47138, 148GNMTglycine52serine52glycine52Blood Vesselvitamin B6NGLY1SLC?ALPIZn2+PNPOPLPPMP23PNP23PNG2323PLPMPN23Zn2+Mg2+Ca2+PLPMPN23PLPMPN23hepatic portal circulationPDXKPLPPMP2323PNP23PLPSLC?23PLP23ALPLZn2+Mg2+Ca2+PLPLPPMP23PL23PAMo-MPTAOX1


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Cobalamin B12, Folate B Riboflavin B2 Pathway into Methionine Cycle & Folate Cycle

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History

CompareRevisionActionTimeUserComment
135487view00:00, 20 September 2024EweitzModified title
135340view23:25, 26 August 2024Alexmadsen1New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
10-formyl-THFMetaboliteCHEBI:15637 (ChEBI)
5, 10-MTHFPGMetaboliteCHEBI:60976 (ChEBI)
5-10MeTHFMetaboliteCHEBI:20502 (ChEBI)
5-MTHFMetaboliteCHEBI:15641 (ChEBI)
ABCD4ProteinO14678 (Uniprot-TrEMBL) cblJ
AHCYProteinP23526 (Uniprot-TrEMBL)
ALDH1L2ProteinQ3SY69 (Uniprot-TrEMBL)
ALPIProteinP09923 (Uniprot-TrEMBL) Intestinal-type alkaline phosphatase
ALPLProteinP05186 (Uniprot-TrEMBL)
AMNProteinQ9BXJ7 (Uniprot-TrEMBL) aka amnionless
AOX1ProteinQ06278 (Uniprot-TrEMBL) Aldehyde oxidase
AdoCblMetaboliteCHEBI:18408 (ChEBI)
B2MetaboliteCHEBI:17015 (ChEBI)
B9MetaboliteCHEBI:27470 (ChEBI)
BHMTProteinQ93088 (Uniprot-TrEMBL)
CBLIFProteinP27352 (Uniprot-TrEMBL)
  • aka (gastric) intrinsic factor, transcobalamin III
  • Located in gastric parietal cells
CBSProteinP35520 (Uniprot-TrEMBL)
CD320ProteinQ9NPF0 (Uniprot-TrEMBL) Aka CD320 receptor
CUBNProteinO60494 (Uniprot-TrEMBL) aka cubilin
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CblMetaboliteCHEBI:23334 (ChEBI)
DHFMetaboliteCHEBI:23743 (ChEBI)
DHFRProteinP00374 (Uniprot-TrEMBL)
DNMT1ProteinP26358 (Uniprot-TrEMBL)
FADMetaboliteCHEBI:57692 (ChEBI) cofactor
FLAD1MetaboliteQ8NFF5 (ChEBI)
FMNMetabolitecHEBI:58210 (ChEBI)
FOLH1GeneProductQ04609 (Uniprot-TrEMBL)
FOLR1ProteinP15328 (Uniprot-TrEMBL)
FOLR2ProteinP14207 (Uniprot-TrEMBL)
GNMTProteinQ14749 (Uniprot-TrEMBL)
HCFC1 (cblX)GeneProductP51610 (Uniprot-TrEMBL)
LMBRD1ProteinQ9NUN5 (Uniprot-TrEMBL) cblF
MAT1AProteinQ00266 (Uniprot-TrEMBL)
MAT2BProteinQ9NZL9 (Uniprot-TrEMBL)
MMAAProteinQ8IVH4 (Uniprot-TrEMBL) cbLA
MMABProtein60488 (Uniprot-TrEMBL) cblB
MMACHCProteinQ9Y4U1 (Uniprot-TrEMBL) cbLC
MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
MMUTProteinP22033 (Uniprot-TrEMBL) aka methylmalonyl-CoA mutase or MCM
MTHFD1ProteinP11586 (Uniprot-TrEMBL)
MTHFRProteinP42898 (Uniprot-TrEMBL)
MTRProteinQ99707 (Uniprot-TrEMBL)
MTRRProteinQ9UBK8 (Uniprot-TrEMBL)
MeCbl(III)alaminMetaboliteCHEBI:28115 (ChEBI)
MetMetaboliteCHEBI:64558 (ChEBI)
Methylmalonyl-CoAMetaboliteCHEBI:16625 (ChEBI)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
Mo-MPTMetaboliteCHEBI:71302 (ChEBI) Mo-molybdopterin
NGLY1ProteinQ96IV0 (Uniprot-TrEMBL) PNG hydrolase, PNGH
PAMetaboliteCHEBI:17405 (ChEBI) 4-pyridoxic acid
PDXKProteinO00764 (Uniprot-TrEMBL)
PLMetaboliteCHEBI:17310 (ChEBI) pyridoxal
PLPMetaboliteCHEBI:597326 (ChEBI) pyridoxal 5'-phosphate
PMMetaboliteCHEBI:57761 (ChEBI) pyridoxamine
PMPMetaboliteCHEBI:18335 (ChEBI) pyridoxamine 5'-phosphate
PNMetaboliteCHEBI:28803 (ChEBI) pyridoxine, vitamin B6
PNGMetaboliteCHEBI:17382 (ChEBI) pyridoxine-5′-β-D-glucoside
PNPMetaboliteCHEBI:28803 (ChEBI) pyridoxine 5′-phosphate
PNPOProteinQ9NVS9 (Uniprot-TrEMBL)
R-cob(III)alaminMetaboliteCHEBI:140785 (ChEBI)
RFKProteinQ969G6 (Uniprot-TrEMBL)
SAHMetaboliteCHEBI:16680 (ChEBI)
SAMe MetaboliteCHEBI:59789 (ChEBI)
SHMT1ProteinP34896 (Uniprot-TrEMBL)
SLC19A1ProteinP41440 (Uniprot-TrEMBL)
SLC46A1ProteinQ96NT5 (Uniprot-TrEMBL)
SLC52A1GeneProductQ9NWF4 (Uniprot-TrEMBL)
SLC52A2GeneProductQ9HAB3 (Uniprot-TrEMBL)
SLC52A3GeneProductQ9NQ40 (Uniprot-TrEMBL)
SLC?Protein
Succinyl-CoAMetaboliteCHEBI:15380 (ChEBI)
TCN1ProteinP20061 (Uniprot-TrEMBL)
  • aka haptocorrin or transcobalamin 1
  • Produced in saliva and stomach
TCN2ProteinP20062 (Uniprot-TrEMBL) aka Transcobalamin 2
THF-polyglutamateMetaboliteCHEBI:28624 (ChEBI)
THFMetaboliteCHEBI:26907 (ChEBI)
TYMSProteinP04818 (Uniprot-TrEMBL)
Zn2+MetaboliteCHEBI:29105 (ChEBI)
acetateMetaboliteCHEBI:58251 (ChEBI)
cbLA MMAAProteinQ8IVH4 (Uniprot-TrEMBL) Gene: MMAA
cob(I)alaminMetaboliteCHEBI:15982 (ChEBI)
cob(II)alaminMetaboliteCHEBI:16304 (ChEBI) Should be cob(II)alamin according to literature
cobalamins MetaboliteCHEBI:23334 (ChEBI)
cystathionineMetaboliteCHEBI:58161 (ChEBI)
glycine betaineMetaboliteCHEBI:17750 (ChEBI)
glycineMetaboliteCHEBI:57305 (ChEBI)
homocysteineMetaboliteCHEBI:58199 (ChEBI)
hydroxocobalaminMetaboliteCHEBI:27786 (ChEBI)
sarcosineMetaboliteCHEBI:57433 (ChEBI)
serineMetaboliteQ82980657 (Wikidata)
vitamin B12Metabolite
vitamin B6MetaboliteCHEBI:27306 (ChEBI)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
SAMe SAHmim-conversion13681 (Rhea) a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
SAMe SAHmim-conversion19937 (Rhea) glycine + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + sarcosine
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5488"
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